Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 77 prodotti di "Ubiquitinazione"
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CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
Formula:C24H24N6OPurezza:97.66%Colore e forma:SoildPeso molecolare:412.49P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:279.33Ref: TM-T28284
1mg144,00€5mg330,00€10mg452,00€25mg633,00€50mg842,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)251,00€Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormula:C31H35F5N6OPurezza:98%Colore e forma:SolidPeso molecolare:602.64Cbl-b-IN-10
CAS:Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Formula:C31H37F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:566.66CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Formula:C20H21Cl2NO6Purezza:99.03%Colore e forma:SolidPeso molecolare:442.29Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormula:C30H33F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:566.62Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormula:C29H31F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:557.58Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Formula:C21H14F3N3O2SPurezza:98.396% - 99.88%Colore e forma:SolidPeso molecolare:429.42Ref: TM-T13244
5mg66,00€10mg90,00€25mg165,00€50mg264,00€100mg395,00€500mg888,00€1mL*10mM (DMSO)73,00€Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Formula:C29H30F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:537.58Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Formula:C30H32F5N5OPurezza:98%Colore e forma:SolidPeso molecolare:573.6Cbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100
Formula:C28H29F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:538.56UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:594.68Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Formula:C27H32N4OPurezza:98%Colore e forma:SolidPeso molecolare:428.57LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurezza:97.12%Colore e forma:SolidPeso molecolare:314.32Cbl-b-IN-8
CAS:Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5Formula:C35H44F3N7O3Purezza:98%Colore e forma:SolidPeso molecolare:667.76PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.
Formula:C14H7ClFN3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:351.67UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormula:C19H18N2OSPurezza:99.3%Colore e forma:SolidPeso molecolare:322.42BC-1293
CAS:BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.Formula:C26H28N4O4SPurezza:98.40%Colore e forma:SolidPeso molecolare:492.59DCN1-UBC12-IN-4
CAS:DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 (IC₅₀ > 10 μM), applicable for investigating cancer cell migration and invasion.Formula:C8H6ClN3SPurezza:98.32%Colore e forma:SolidPeso molecolare:211.67p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.51VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formula:C24H23N5O2Colore e forma:SolidPeso molecolare:413.47PRC1-IN-1
CAS:PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.Formula:C24H19ClFN3O2Colore e forma:SolidPeso molecolare:435.878Cbl-b-IN-26
CAS:Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Formula:C21H19F3N6Colore e forma:SolidPeso molecolare:412.41SPOP-IN-2
CAS:SPOP-IN-2 (Compound E1) is a potent inhibitor of speckle-type POZ protein (SPOP), with an IC50 of 0.58 μM. It disrupts the interaction between SPOP and substrates and selectively inhibits the proliferation of clear cell renal cell carcinoma (ccRCC).Formula:C15H13ClN2O5SPeso molecolare:368.79Cbl-b-IN-3
CAS:Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Formula:C30H34F3N5OPurezza:97.63%Colore e forma:SolidPeso molecolare:537.62Ref: TM-T63790
1mg66,00€5mg145,00€10mg192,00€25mg364,00€50mg558,00€100mg893,00€1mL*10mM (DMSO)172,00€USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.
Formula:C19H20ClN3O5SPurezza:99.76%Colore e forma:SoildPeso molecolare:437.9USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).
Formula:C22H23N3O3Purezza:99.509% - 99.81%Colore e forma:SolidPeso molecolare:377.44
