Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurezza:99.64% - 99.91%Colore e forma:SolidPeso molecolare:348.42Neflamapimod
CAS:Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.Formula:C19H9Cl2F2N3OSPurezza:97.88% - 99.75%Colore e forma:SolidPeso molecolare:436.26Turofexorate Isopropyl
CAS:<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Formula:C25H24F2N2O3Purezza:98.55% - 99.73%Colore e forma:SolidPeso molecolare:438.47SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurezza:99.3% - >99.99%Colore e forma:SolidPeso molecolare:405.42Milciclib
CAS:Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Formula:C25H32N8OPurezza:99.28%Colore e forma:SolidPeso molecolare:460.57Ref: TM-T6081
1mg51,00€5mg106,00€10mg177,00€25mg376,00€50mg603,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)110,00€STF-62247
CAS:<p>STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.</p>Formula:C15H13N3SPurezza:99.6% - 99.67%Colore e forma:SolidPeso molecolare:267.35Fenretinide
CAS:Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.Formula:C26H33NO2Purezza:98% - 99.68%Colore e forma:Yellow PowderPeso molecolare:391.55CD437
CAS:CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.Formula:C27H26O3Purezza:98.92% - 99.63%Colore e forma:SolidPeso molecolare:398.49FERULIC ACID METHYL ESTER
CAS:FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.Formula:C11H12O4Purezza:99.66% - 99.95%Colore e forma:SolidPeso molecolare:208.21LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formula:C31H38N8O3Purezza:98% - 98.82%Colore e forma:SolidPeso molecolare:570.69Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formula:C20H20BrN3O2S·2HClPurezza:98.22% - >99.99%Colore e forma:SolidPeso molecolare:519.28Ref: TM-T6250
5mg39,00€10mg58,00€25mg106,00€50mg202,00€100mg344,00€200mg512,00€500mg815,00€1mL*10mM (DMSO)52,00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purezza:98.63% - >99.99%Colore e forma:Yellow SolidPeso molecolare:267.28Ref: TM-T2623
5mg40,00€10mg52,00€25mg82,00€50mg106,00€100mg177,00€200mg264,00€500mg444,00€1mL*10mM (DMSO)58,00€ML327
CAS:ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Formula:C19H18N4O4Purezza:98.47%Colore e forma:SolidPeso molecolare:366.37Ref: TM-T4252
1mg49,00€2mg65,00€5mg97,00€10mg144,00€25mg235,00€50mg376,00€100mg645,00€200mg898,00€1mL*10mM (DMSO)106,00€Sitagliptin phosphate
CAS:Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.Formula:C16H18F6N5O5PPurezza:99.72% - 99.91%Colore e forma:White SolidPeso molecolare:505.31KN-92 phosphate
CAS:KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93.Formula:C24H28ClN2O7PSPurezza:99.86%Colore e forma:SolidPeso molecolare:554.98Ref: TM-T4530
2mg35,00€5mg70,00€10mg105,00€25mg170,00€50mg259,00€100mg368,00€200mg522,00€1mL*10mM (DMSO)85,00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purezza:95.84% - 99.77%Colore e forma:White SolidPeso molecolare:428.43Ref: TM-T6283
1mg38,00€2mg49,00€5mg80,00€10mg119,00€25mg235,00€50mg406,00€100mg602,00€1mL*10mM (DMSO)88,00€Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurezza:98.73% - 98.87%Colore e forma:SolidPeso molecolare:486.8Ref: TM-T8399
5mg37,00€10mg52,00€25mg82,00€50mg99,00€100mg138,00€200mg171,00€500mg227,00€1mL*10mM (DMSO)59,00€Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formula:C26H30N6O3Purezza:97.88% - 98.79%Colore e forma:White PowderPeso molecolare:474.553-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formula:C6H7N5Purezza:98% - 99.51%Colore e forma:SolidPeso molecolare:149.15WYC-209
CAS:WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).Formula:C20H20N2O3SPurezza:99.77%Colore e forma:SolidPeso molecolare:368.45Salirasib
CAS:Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Formula:C22H30O2SPurezza:99.45%Colore e forma:SolidPeso molecolare:358.54Ref: TM-T6163
5mg35,00€10mg52,00€25mg96,00€50mg159,00€100mg221,00€200mg364,00€500mg597,00€1mL*10mM (DMSO)59,00€MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formula:C26H37ClN6O2Purezza:98.19%Colore e forma:SolidPeso molecolare:501.07Afatinib Dimaleate
CAS:Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Formula:C32H33ClFN5O11Purezza:98.11% - 99.87%Colore e forma:SolidPeso molecolare:718.08TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Formula:C20H13F2N3Purezza:99.35% - 99.79%Colore e forma:SolidPeso molecolare:333.33Sepantronium bromide
CAS:<p>Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.</p>Formula:C20H19BrN4O3Purezza:99.68% - 99.85%Colore e forma:SolidPeso molecolare:443.26LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purezza:98% - 99.96%Colore e forma:Pale Yellow SolidPeso molecolare:307.34PFI-1
CAS:PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.Formula:C16H17N3O4SPurezza:98.74% - 99.19%Colore e forma:SolidPeso molecolare:347.393'-Hydroxypterostilbene
CAS:3'-Hydroxypterostilbene suppresses colon cancer cell growth (COLO 205, HCT-116, HT-29) by triggering apoptosis and autophagy, affecting key pathways.Formula:C16H16O4Purezza:98.25% - 99.19%Colore e forma:SolidPeso molecolare:272.3BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formula:C14H15ClN6OPurezza:98% - 99.82%Colore e forma:SolidPeso molecolare:318.76Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Formula:C15H15N7OPurezza:99.19% - >99.99%Colore e forma:SolidPeso molecolare:309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€1mL*10mM (DMSO)88,00€Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Formula:C21H21Cl2NO5Purezza:98.87% - 99.88%Colore e forma:SolidPeso molecolare:438.3Orthanilamide
CAS:Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.Formula:C6H8N2O2SPurezza:99.72% - 99.96%Colore e forma:White To Pale Cream Crystalline Powder Or CrystalsPeso molecolare:172.2Doramapimod HCl
CAS:Doramapimod HCl, a p38MAPK inhibitor in clinical trials for autoimmune diseases, has slow binding kinetics.Formula:C31H38ClN5O3Colore e forma:SolidPeso molecolare:564.13AGN 193109
CAS:AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).Formula:C28H24O2Purezza:99.87% - 99.89%Colore e forma:SolidPeso molecolare:392.49Ref: TM-TQ0097
2mg90,00€5mg153,00€10mg235,00€25mg424,00€50mg655,00€100mg938,00€1mL*10mM (DMSO)Prezzo su richiestaMPP+ iodide
CAS:MPP+ iodide, a neurotoxin byproduct, mimics Parkinson's by killing substantia nigra neurons and affecting neuron transporters, inducing cell death.Formula:C12H12INPurezza:99.49% - 99.96%Colore e forma:SolidPeso molecolare:297.13GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Formula:C24H18FN3O2Purezza:99.57% - 99.94%Colore e forma:SolidPeso molecolare:399.42Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormula:C29H31N7OPurezza:99.42% - 99.94%Colore e forma:Off White PowderPeso molecolare:493.6Demethoxycurcumin
CAS:Demethoxycurcumin: antioxidant, anti-inflammatory, anti-proliferative, anti-acanthamoebic, enhances chemo for resistant cancers, inhibits cancer pathways.Formula:C20H18O5Purezza:94.54% - 99.86%Colore e forma:SolidPeso molecolare:338.35Ref: TM-T6S1683
5mg44,00€10mg55,00€25mg93,00€50mg158,00€100mg224,00€200mg330,00€1mL*10mM (DMSO)55,00€Cilofexor tromethamine
CAS:Cilofexor (GS-9674), a nonsteroidal FXR agonist, reduces cholestasis and liver damage in PSC, showing safety and efficacy in trials.Formula:C32H33Cl3N4O8Colore e forma:SolidPeso molecolare:707.99Aloperine
CAS:Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.Formula:C15H24N2Purezza:98% - 99.88%Colore e forma:Yellow Crystalline PowderPeso molecolare:232.36Arglabin
CAS:Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Formula:C15H18O3Purezza:98.97% - 99.62%Colore e forma:SolidPeso molecolare:246.3Ref: TM-TQ0165
1mg88,00€2mgPrezzo su richiesta5mg240,00€10mg360,00€25mg518,00€50mg692,00€100mg1.035,00€200mg1.388,00€1mL*10mM (DMSO)310,00€Bilobalide
CAS:Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.Formula:C15H18O8Purezza:98.81% - 99.92%Colore e forma:White SolidPeso molecolare:326.30Amsacrine gluconate
CAS:Amsacrine gluconate: an aminoacridine with anticancer properties, possibly works by intercalating DNA and inhibiting topoisomerase II.Formula:C27H31N3O10SColore e forma:SolidPeso molecolare:589.62Apocynin
CAS:Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).Formula:C9H10O3Purezza:99.71% - 99.98%Colore e forma:Yellowish To Brown PowderPeso molecolare:166.17HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purezza:99.77% - 99.86%Colore e forma:SolidPeso molecolare:466.58Ref: TM-T6855
1mg35,00€2mg48,00€5mg72,00€10mg96,00€25mg187,00€50mg283,00€100mg439,00€1mL*10mM (DMSO)74,00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purezza:97.86% - 99.27%Colore e forma:SolidPeso molecolare:451.34Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purezza:98.03% - >99.99%Colore e forma:SolidPeso molecolare:441.23Reparixin
CAS:Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formula:C14H21NO3SPurezza:98% - 99.89%Colore e forma:SolidPeso molecolare:283.39Ref: TM-T4163
5mg48,00€10mg62,00€25mg120,00€50mg187,00€100mg301,00€200mg449,00€1mL*10mM (DMSO)111,00€Daurisoline
CAS:Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.Formula:C37H42N2O6Purezza:98% - 99.96%Colore e forma:Light Yellow PowderPeso molecolare:610.74
