Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1490 prodotti di "Autofagia"
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Britannin
CAS:Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.Formula:C19H26O7Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:366.41Verteporfin
CAS:Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.Formula:C41H42N4O8Purezza:95.37% - 99.82%Colore e forma:Dark Green To Black SolidPeso molecolare:718.79Ref: TM-T3112
1mg40,00€2mg51,00€5mg85,00€10mg115,00€25mg225,00€50mg365,00€100mg462,00€1mL*10mM (DMSO)120,00€Ralimetinib dimesylate
CAS:Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.Formula:C24H29FN6·2CH4O3SPurezza:98% - 99.38%Colore e forma:SolidPeso molecolare:612.74Hydroxyprogesterone caproate
CAS:Hydroxyprogesterone caproate (Delalutin) is a synthetic progestin that activates progesterone receptors and inhibits ovulation.Formula:C27H40O4Purezza:99.70%Colore e forma:White Or Almost White Crystalline PowerPeso molecolare:428.60Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurezza:98.89% - 99.28%Colore e forma:SolidPeso molecolare:265.25Bardoxolone Methyl
CAS:Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-Formula:C32H43NO4Purezza:97.81% - 99.09%Colore e forma:SolidPeso molecolare:505.69BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Formula:C22H27ClN6O2Purezza:97.57% - 98.75%Colore e forma:SolidPeso molecolare:442.95Ref: TM-T3462
1mg35,00€5mg71,00€10mg101,00€25mg170,00€50mg264,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)78,00€Tazarotene
CAS:Tazarotene (Zorac), a synthetic topical retinoid, treats psoriasis by normalizing keratinocytes and reducing growth.Formula:C21H21NO2SPurezza:97.01% - 99.14%Colore e forma:White SolidPeso molecolare:351.46Ref: TM-T6696
5mg38,00€10mg49,00€25mg88,00€50mg147,00€100mg256,00€200mg334,00€500mg563,00€1mL*10mM (DMSO)55,00€Deguelin
CAS:Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.Formula:C23H22O6Purezza:96.39% - 99.29%Colore e forma:SolidPeso molecolare:394.42BIA 10-2474
CAS:BIA 10-2474 is a long-acting reversible inhibitor of FAAH that increases levels of the neurotransmitter anandamide in the nervous system.Formula:C16H20N4O2Purezza:99.27%Colore e forma:SolidPeso molecolare:300.36Pirarubicin
CAS:Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Formula:C32H37NO12Purezza:97.80% - 99.15%Colore e forma:Red Crystalline PowderPeso molecolare:627.64kaempferide
CAS:kaempferide (4'-Methylkaempferol) is an O-methylated flavonol present in Kaempferia kaempferi with antiviral activity.Formula:C16H12O6Purezza:98.4% - 99.66%Colore e forma:SolidPeso molecolare:300.26SR12813
CAS:SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.Formula:C24H42O7P2Purezza:99.43%Colore e forma:SolidPeso molecolare:504.53GSK-690693
CAS:GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.Formula:C21H27N7O3Purezza:98.07% - 99.77%Colore e forma:SolidPeso molecolare:425.48Pantoprazole sodium
CAS:Pantoprazole sodium is a proton pump inhibitor that irreversibly blocks gastric acid secretion by bonding with H+/K+-ATPase.Formula:C16H14F2N3NaO4SPurezza:96.92% - 99.81%Colore e forma:White To Off-White SolidPeso molecolare:405.35LX2343
CAS:LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Formula:C22H19ClN2O6SPurezza:99.45%Colore e forma:SolidPeso molecolare:474.91Ref: TM-T4398
2mg37,00€5mg52,00€10mg84,00€25mg137,00€50mg229,00€100mg340,00€200mg472,00€1mL*10mM (DMSO)58,00€Cabergoline diphosphate
CAS:Cabergoline, a D2 receptor agonist, treats prolactinomas by normalizing prolactin levels.Formula:C26H43N5O10P2Colore e forma:SolidPeso molecolare:647.6PF-4708671
CAS:PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).Formula:C19H21F3N6Purezza:99.48% - 99.98%Colore e forma:SolidPeso molecolare:390.41Chelerythrine chloride
CAS:Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect toFormula:C21H18ClNO4Purezza:95% - 99.19%Colore e forma:Yellow To Orange SolidPeso molecolare:383.83Ref: TM-T3419
2mg34,00€5mg50,00€10mg84,00€25mg145,00€50mg205,00€100mg289,00€200mg432,00€1mL*10mM (DMSO)65,00€BI-D1870
CAS:BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.Formula:C19H23F2N5O2Purezza:98.51% - 99.43%Colore e forma:SolidPeso molecolare:391.42VLX600
CAS:VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.Formula:C17H15N7Purezza:98.62%Colore e forma:SolidPeso molecolare:317.35Ganoderic acid A
CAS:Ganoderic acid A fights tumors, suppresses gene regulators, induces cancer cell death, and enhances cisplatin efficacy.Formula:C30H44O7Purezza:99.31% - ≥95%Colore e forma:SolidPeso molecolare:516.67Ref: TM-T6S1141
1mg47,00€5mg97,00€10mg160,00€25mg250,00€50mg374,00€100mg547,00€1mL*10mM (DMSO)110,00€PAC-1
CAS:<p>PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.</p>Formula:C23H28N4O2Purezza:96.78% - 99.77%Colore e forma:SolidPeso molecolare:392.49Bromocriptine mesylate
CAS:Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)Formula:C33H44BrN5O8SPurezza:99.85% - 99.96%Colore e forma:White SolidPeso molecolare:750.7Berbamine
CAS:Berbamine is a natural product extracted from Phellodendron amurense.Formula:C37H40N2O6Purezza:98.92% - 99.67%Colore e forma:White Crystal PowderPeso molecolare:608.72Skepinone-L
CAS:Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.Formula:C24H21F2NO4Purezza:99.56% - >99.99%Colore e forma:SolidPeso molecolare:425.42Ref: TM-T6130
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg208,00€50mg313,00€100mg465,00€1mL*10mM (DMSO)87,00€SR9011
CAS:SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).Formula:C23H31ClN4O3SPurezza:99.64% - 99.65%Colore e forma:SolidPeso molecolare:479.042-Methoxyestradiol
CAS:2-ME2, an estradiol derivative, hinders angiogenesis and tumor growth, causes cell apoptosis, and stops mitosis.Formula:C19H26O3Purezza:98% - 99.95%Colore e forma:Off-White SolidPeso molecolare:302.41Necrostatin-1
CAS:Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.Formula:C13H13N3OSPurezza:99.25% - >99.99%Colore e forma:SolidPeso molecolare:259.33Ref: TM-T1847
5mg35,00€10mg49,00€25mg82,00€50mg113,00€100mg170,00€200mg250,00€500mg419,00€1mL*10mM (DMSO)52,00€Fendiline
CAS:Fendiline: coronary vasodilator, calcium blocker, potential antiarrhythmic/antianginal.Formula:C23H25NColore e forma:SolidPeso molecolare:315.45DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Formula:C6H9NO5Purezza:80.23% - 99.98%Colore e forma:SolidPeso molecolare:175.14KN-62
CAS:KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.Formula:C38H35N5O6S2Purezza:99.80% - >99.99%Colore e forma:White SolidPeso molecolare:721.84Ref: TM-T2694
1mg34,00€2mg49,00€5mg71,00€10mg105,00€25mg207,00€50mg404,00€100mg592,00€1mL*10mM (DMSO)105,00€Alirocumab
CAS:Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.Purezza:95% - 97.1% (SDS-PAGE); 96.1% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:146.2 kDaAdezmapimod
CAS:Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.Formula:C21H16FN3OSPurezza:99.42% - 99.93%Colore e forma:White SolidPeso molecolare:377.43Heparin sodium salt
CAS:Heparin sodium, a sulfated glycosaminoglycan, acts as an anticoagulant and inhibits exosome-cell interactions.Formula:C26H42N2NaO37S5Purezza:98%Colore e forma:SolidPeso molecolare:1157.89Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formula:C15H12O5Purezza:98.76% - >99.99%Colore e forma:SolidPeso molecolare:272.25Ref: TM-T6427
1mg43,00€2mg56,00€5mg88,00€10mg106,00€25mg213,00€50mg344,00€100mg550,00€1mL*10mM (DMSO)87,00€GW 501516
CAS:GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.Formula:C21H18F3NO3S2Purezza:98.91% - 99.64%Colore e forma:White SolidPeso molecolare:453.50Gambogic Acid
CAS:Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases.Formula:C38H44O8Purezza:97.16% - 98.67%Colore e forma:SolidPeso molecolare:628.75Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formula:C17H21N6O4PPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:404.36Ref: TM-T3043
1g583,00€5mg49,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1mL*10mM (DMSO)56,00€Perifosine
CAS:Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.Formula:C25H52NO4PPurezza:99.80 - >99.99%Colore e forma:SolidPeso molecolare:461.66Atorvastatin strontium
CAS:Atorvastatin strontium lowers cholesterol, prevents heart disease, and treats dyslipidemia by inhibiting HMG-CoA reductase.Formula:C66H68F2N4O10SrColore e forma:SolidPeso molecolare:1202.9GANT 61
CAS:<p>GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.</p>Formula:C27H35N5Purezza:97.59% - >99.99%Colore e forma:SolidPeso molecolare:429.6UVI 3003
CAS:UVI 3003 blocks retinoid X receptor (RXRα) in Xenopus/human Cos7 cells; IC50: 0.22/0.24 μM.Formula:C28H36O4Purezza:99.82%Colore e forma:SolidPeso molecolare:436.58Ref: TM-T17209
1mg35,00€2mg52,00€5mg74,00€10mg119,00€25mg243,00€50mg406,00€100mg607,00€1mL*10mM (DMSO)86,00€Dansylcadaverine
CAS:Dansylcadaverine (Monodansyl cadaverine) is a fluorescent probe.Formula:C17H25N3O2SPurezza:98.33% - 99.6%Colore e forma:SolidPeso molecolare:335.46Pemetrexed disodium hemipenta hydrate
CAS:<p>Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT.</p>Formula:C20H21N5O6·2NaH2OPurezza:98.76%Colore e forma:SolidPeso molecolare:518.43SD 0006
CAS:SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.Formula:C20H20ClN5O2Purezza:98.32%Colore e forma:SolidPeso molecolare:397.86Ref: TM-T7276
2mg38,00€5mg58,00€10mg90,00€25mg145,00€50mg226,00€100mg338,00€200mg472,00€1mL*10mM (DMSO)65,00€BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Formula:C25H44O3Purezza:99.95%Colore e forma:SolidPeso molecolare:392.62Atezolizumab
CAS:Atezolizumab is an antibody inhibitor, a humanized monoclonal antibody, IgG1, which targets PD-L1. Atezolizumab has antitumor effect. Cost-effective and quality-assured.Purezza:95.10% - 99.3% （SEC-HPLC）Colore e forma:LiquidPeso molecolare:145 kDaDacinostat
CAS:LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.Formula:C22H25N3O3Purezza:95.28% - 97.88%Colore e forma:SolidPeso molecolare:379.45Ref: TM-T2454
1mg49,00€2mg67,00€5mg110,00€10mg180,00€25mg323,00€50mg487,00€100mg705,00€500mg1.444,00€1mL*10mM (DMSO)110,00€PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Formula:C26H22N4O3Purezza:98.80% - ≥95%Colore e forma:SolidPeso molecolare:438.48
