Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1488 prodotti di "Autofagia"
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GC7 Sulfate
CAS:GC7 Sulfate blocks DHS, the sole enzyme activating eIF5A2, thus preventing eIF5A2 activation.Formula:C8H22N4O4SPurezza:98.07% - 99.85%Colore e forma:SolidPeso molecolare:270.35AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formula:C15H14F2N4O2S2Purezza:98.35% - 99.67%Colore e forma:SolidPeso molecolare:384.42MTK458
CAS:<p>MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.</p>Formula:C17H15F3N4Purezza:98.36%Colore e forma:SolidPeso molecolare:332.32Apostatin-1
CAS:Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.Formula:C19H27N3OSPurezza:99.31%Colore e forma:SolidPeso molecolare:345.5CHIR-99021 HCl
CAS:CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formula:C22H19Cl3N8Purezza:98.07% - 98.14%Colore e forma:SolidPeso molecolare:501.8LY2955303
CAS:LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).Formula:C36H42N4O3Purezza:98.56% - 99.85%Colore e forma:SolidPeso molecolare:578.74p38-α MAPK-IN-1
CAS:p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.Formula:C27H35N5O3Purezza:99.93%Colore e forma:SolidPeso molecolare:477.6Cisd2 agonist 1
CAS:Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).Formula:C14H13FN2O3SPurezza:99.06%Colore e forma:SolidPeso molecolare:308.33Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Formula:C11H12F3NNaO6S2Colore e forma:SolidPeso molecolare:398.32SLLN-15
CAS:SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.Formula:C19H23N7Se2Purezza:98%Colore e forma:SolidPeso molecolare:507.35CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formula:C17H15FN2O4SColore e forma:SolidPeso molecolare:362.38(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formula:C32H28F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:603.59Calmidazolium chloride
CAS:Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.Formula:C31H23Cl7N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:687.7KN-93 Phosphate
CAS:KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.Formula:C26H32ClN2O8PSPurezza:99.58% - 99.93%Colore e forma:SolidPeso molecolare:599.03CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formula:C17H17FN2O4SColore e forma:SolidPeso molecolare:364.39USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:497.58CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formula:C15H17N5O3Colore e forma:SolidPeso molecolare:315.33SR10067
CAS:SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.Formula:C31H31NO3Purezza:99.57%Colore e forma:SolidPeso molecolare:465.58NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formula:C23H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:468.46
