DUB
Gli inibitori delle deubiquitinasi (DUB) mirano alle enzimi che rimuovono le molecole di ubiquitina dalle proteine, regolando così la stabilità, la localizzazione e l'attività delle proteine all'interno della cellula. Le deubiquitinasi svolgono ruoli essenziali in vari processi cellulari, tra cui la regolazione del ciclo cellulare, la riparazione del DNA e le risposte immunitarie. La disfunzione dell'attività delle DUB è legata al cancro, ai disturbi neurodegenerativi e alle infezioni virali. Gli inibitori delle DUB possono modulare questi processi, offrendo potenziali approcci terapeutici per queste condizioni. Presso CymitQuimica, forniamo inibitori delle DUB per supportare la tua ricerca in omeostasi proteica, oncologia e neurobiologia.
Trovati 89 prodotti di "DUB"
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IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Formula:C19H23ClN2OPurezza:98.94%Colore e forma:SolidPeso molecolare:330.85Ref: TM-T15604
1mg35,00€5mg67,00€10mg115,00€25mg235,00€50mg378,00€100mg627,00€200mg875,00€1mL*10mM (DMSO)73,00€C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formula:C17H8FNO3Purezza:97.22%Colore e forma:SolidPeso molecolare:293.25MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formula:C30H37N3O4SPurezza:99.93%Colore e forma:SolidPeso molecolare:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg934,00€1mL*10mM (DMSO)104,00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
Formula:C25H28ClN3OPurezza:97.71%Colore e forma:SolidPeso molecolare:421.96GRL0617
CAS:GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).Formula:C20H20N2OPurezza:99.31%Colore e forma:SolidPeso molecolare:304.39Ref: TM-T11464
1mg34,00€5mg74,00€10mg105,00€25mg178,00€50mg313,00€100mg500,00€500mg1.063,00€1mL*10mM (DMSO)82,00€EN523
CAS:EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Formula:C12H14N2O3Purezza:99.5%Colore e forma:SolidPeso molecolare:234.25Ref: TM-T9884
1mg34,00€5mg66,00€10mg99,00€25mg222,00€50mg356,00€100mg570,00€200mg800,00€1mL*10mM (DMSO)67,00€Subquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Formula:C20H27N3O4SColore e forma:SolidPeso molecolare:405.17223T20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Formula:C87H140N22O26SColore e forma:SolidPeso molecolare:1942.24BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Formula:C24H28F3N5O2SColore e forma:SolidPeso molecolare:507.57MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Colore e forma:Odour SolidGK16S
GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].Formula:C11H15N3OColore e forma:SoildPeso molecolare:205.12151USP7-IN-15
USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.Colore e forma:Odour SolidUBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Colore e forma:Odour SolidUSP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Colore e forma:Odour SolidGK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formula:C21H22N6O2Colore e forma:SolidPeso molecolare:390.44USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Formula:C26H30Cl2N4O3SColore e forma:SolidPeso molecolare:549.51Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Colore e forma:Odour SolidRef: TM-L8600
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaJAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.44USP7-IN-16
CAS:USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.Formula:C43H45N7O6SColore e forma:SolidPeso molecolare:787.93USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Formula:C18H18F3N5O2SPurezza:99.79%Colore e forma:SolidPeso molecolare:425.43Ref: TM-T67873
1mg34,00€5mg60,00€10mg92,00€25mg195,00€50mg311,00€100mg449,00€500mg888,00€1mL*10mM (DMSO)79,00€
