DUB
Gli inibitori delle deubiquitinasi (DUB) mirano alle enzimi che rimuovono le molecole di ubiquitina dalle proteine, regolando così la stabilità, la localizzazione e l'attività delle proteine all'interno della cellula. Le deubiquitinasi svolgono ruoli essenziali in vari processi cellulari, tra cui la regolazione del ciclo cellulare, la riparazione del DNA e le risposte immunitarie. La disfunzione dell'attività delle DUB è legata al cancro, ai disturbi neurodegenerativi e alle infezioni virali. Gli inibitori delle DUB possono modulare questi processi, offrendo potenziali approcci terapeutici per queste condizioni. Presso CymitQuimica, forniamo inibitori delle DUB per supportare la tua ricerca in omeostasi proteica, oncologia e neurobiologia.
Trovati 89 prodotti di "DUB"
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USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purezza:99.37%Colore e forma:SolidPeso molecolare:338.41GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formula:C17H12FN3Purezza:97.09%Colore e forma:SolidPeso molecolare:277.3Ref: TM-T11485
1mg39,00€2mg50,00€5mg82,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)90,00€6RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formula:C13H17N5O2SPurezza:99.91%Colore e forma:SolidPeso molecolare:307.37Ref: TM-T10188
1mg144,00€5mg298,00€10mg510,00€25mg825,00€50mg1.130,00€100mg1.510,00€500mg3.060,00€1mL*10mM (DMSO)328,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:279.33Ref: TM-T28284
1mg144,00€5mg330,00€10mg452,00€25mg633,00€50mg842,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)251,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormula:C16H8N2O3Purezza:99.72%Colore e forma:SolidPeso molecolare:276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formula:C22H16ClFN2O4Purezza:98.59%Colore e forma:SoildPeso molecolare:426.83USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurezza:98.84% - 99.59%Colore e forma:SolidPeso molecolare:368.41USP7-IN-12
CAS:USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Formula:C29H28ClFN4O2SColore e forma:SolidPeso molecolare:551.07FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColore e forma:SolidPeso molecolare:447.6USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formula:C27H24F3N7OColore e forma:SolidPeso molecolare:519.52USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormula:C27H23F3N8OColore e forma:SolidPeso molecolare:532.52USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formula:C24H28N4O3Colore e forma:SolidPeso molecolare:420.5DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formula:C17H19N5OColore e forma:SolidPeso molecolare:309.37FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formula:C24H23F4N7O3Purezza:99.76%Colore e forma:SolidPeso molecolare:533.48Ref: TM-T12621L
1mgPrezzo su richiesta5mg131,00€10mgPrezzo su richiesta25mg464,00€50mg803,00€100mg1.388,00€USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purezza:98%Colore e forma:SolidPeso molecolare:568.59LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurezza:97.12%Colore e forma:SolidPeso molecolare:314.32USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:497.58Ref: TM-T36682
1mg137,00€5mg281,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€500mg2.673,00€1mL*10mM (DMSO)309,00€USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formula:C29H27F3N8OColore e forma:SolidPeso molecolare:560.57CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormula:C25H29N5O2SColore e forma:SolidPeso molecolare:463.6USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formula:C23H24ClN3O3Purezza:99.82%Colore e forma:SolidPeso molecolare:425.91Ref: TM-T13268
1mg92,00€5mg178,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)207,00€
