Proteina Hedgehog/Smoothened
La via di segnalazione Hedgehog/Smoothened è una via correlata ai GPCR cruciale, coinvolta nello sviluppo embrionale, nella rigenerazione dei tessuti e nel mantenimento delle cellule staminali. Smoothened (SMO) è una proteina transmembrana chiave che trasduce i segnali dai ligandi Hedgehog (Hh) per attivare le cascate di segnalazione a valle. La disregolazione della via Hedgehog/Smoothened è implicata in vari tumori e disturbi dello sviluppo, rendendola un bersaglio significativo per l'intervento terapeutico. Presso CymitQuimica, offriamo una gamma di modulatori di alta qualità per la via Hedgehog/Smoothened per supportare la tua ricerca in biologia dello sviluppo, oncologia e medicina rigenerativa.
Trovati 49 prodotti di "Proteina Hedgehog/Smoothened"
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GANT 58
CAS:<p>GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).</p>Formula:C24H16N4SPurezza:99.53%Colore e forma:SolidPeso molecolare:392.48ALLO-2
CAS:ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Formula:C18H12F3N5OPurezza:99.19%Colore e forma:SolidPeso molecolare:371.32Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formula:C22H23F2N3O2SPurezza:99.64%Colore e forma:SolidPeso molecolare:431.5HPP-9
HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BETFormula:C49H52N6O11Colore e forma:SolidPeso molecolare:900.97SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Formula:C28H30Cl3N3OSPurezza:>99.99%Colore e forma:SoildPeso molecolare:562.98HSP70-IN-3
HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.Formula:C48H78N6O7SColore e forma:SolidPeso molecolare:883.23GI-560192
CAS:GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Formula:C20H16N2O2Purezza:99.53%Colore e forma:SoildPeso molecolare:316.35CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Formula:C31H43ClN4O5Purezza:94.05%Colore e forma:SolidPeso molecolare:587.15WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Formula:C19H17ClN2O2S2Purezza:97.92%Colore e forma:SolidPeso molecolare:404.93HL2-m5
CAS:HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.Formula:C70H101N15O24S3Colore e forma:SolidPeso molecolare:1632.83GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Colore e forma:Odour SolidSANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formula:C26H26ClN3O4Purezza:99.23%Colore e forma:SolidPeso molecolare:479.96JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Formula:C19H18N4OSPurezza:98.93% - 99.89%Colore e forma:SolidPeso molecolare:350.44MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formula:C31H29N3O5SPurezza:99.72%Colore e forma:SolidPeso molecolare:555.64SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Formula:C28H28ClN3OSPurezza:97.37% - 98.88%Colore e forma:SolidPeso molecolare:490.06SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Formula:C28H29Cl2N3OSPurezza:99.19% - 99.97%Colore e forma:SolidPeso molecolare:526.52Glasdegib
CAS:Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Formula:C21H22N6OPurezza:98.72%Colore e forma:SolidPeso molecolare:374.44MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Formula:C24H23N3O5SPurezza:99.73%Colore e forma:SolidPeso molecolare:465.52HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formula:C27H29NO6Purezza:97.6%Colore e forma:SolidPeso molecolare:463.52HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFormula:C24H23ClN4O3Purezza:95.73%Colore e forma:SolidPeso molecolare:450.92
