Proteasi HIV
Gli inibitori della proteasi dell'HIV sono una classe di farmaci antiretrovirali che bersagliano specificamente l'enzima proteasi del virus dell'immunodeficienza umana (HIV). Inibendo questo enzima, questi composti impediscono al virus di elaborare le sue poliproteine in proteine mature e funzionali, bloccando così la produzione di nuovi virioni infettivi. Gli inibitori della proteasi dell'HIV sono una pietra miliare della terapia antiretrovirale altamente attiva (HAART) utilizzata per gestire l'HIV/AIDS. Presso CymitQuimica, offriamo una varietà di inibitori della proteasi dell'HIV per supportare la vostra ricerca nel trattamento dell'HIV, nella resistenza ai farmaci e nella virologia.
Trovati 475 prodotti per "Proteasi HIV".
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GRL-07524
GRL-07524 (Compound 4e) is a potent HIV-1 protease inhibitor with a Ki of 0.22 nM. It contains an oxaspirocarbamate as the P2 ligand and demonstrates strong antiviral activity, with an EC50 of 210 nM. GRL-07524 can bind to the active site of HIV-1PR and crucial catalytic residues, interacting with one of four symmetric-independent molecules.Colore e forma:Odour SolidHIV-1 inhibitor-81
HIV-1inhibitor-81 (Compound 14g) is an HIV-1 protease inhibitor with a Ki of 1.6 nM. This compound exhibits antiviral activity against HIV-1, with an EC50 value of 250 nM.Formula:C32H44N2O8SColore e forma:SolidPeso molecolare:616.77HIV gag peptide (197-205)
CAS:HIV gag peptide (197-205) is a H-2Kd-restricted epitope derived from the p24 portion of the HIV-1 gag protein and composed of the amino acid 197-205 (AMQMLKETIFormula:C45H81N11O14S2Purezza:98%Colore e forma:SolidPeso molecolare:1064.32NNRT-IN-6
NNRT-IN-6 (Compound 13a) is a non-nucleoside reverse transcriptase inhibitor (NNRT) used to inhibit HIV-1 reverse transcriptase (HIV-1RT), with an IC50 of 0.41 μM. It effectively suppresses both wild-type HIV-1 and mutants L100I, K103N, Y181C, Y188L, E138K, F227L/V106A, and RES056, with an EC50 range of 6.2-250 nM.Formula:C32H31N9O3SColore e forma:SolidPeso molecolare:621.71HIV-1 inhibitor-59
HIV-1 Inhibitor-59 (Compound I-5b) effectively inhibits both wild-type and mutant strains of HIV-1, with EC50 values ranging from 5.62 to 171 nM.Formula:C28H28FN5O3SColore e forma:SolidPeso molecolare:533.62Carbovir triphosphate
CAS:Carbovir triphosphate (CBV-TP), a phosphorylated metabolite, serves as a research tool for studying human immunodeficiency virus (HIV) [1].Formula:C11H16N5O11P3Colore e forma:SolidPeso molecolare:487.19HIV-IN-12
HIV-IN-12 (Compound A1) is a dual inhibitor targeting both HIV-1 Vif and reverse transcriptase (RT). It shows potential for use in HIV infection research.F9170 TFA
F9170, an antiviral peptide derived from the HIV-1 envelope glycoprotein (amino acids 789-803), targets the LLP1 domain in the virus's envelope proteinFormula:C100H135N21O22·XCF3COOHPeso molecolare:1983.30NNRT-IN-11
NNRT-IN-11 (14l) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor, exhibiting EC50 values ranging from 6.50 to 52.9 nM against both wild-type (WT) and a range of HIV-1 mutant strains. NNRT-IN-11 demonstrates antiviral properties.Colore e forma:Odour SolidHIV p17 Gag (77-85)
CAS:Targeting HIV Gag p17 (77-85) with intracellular Ab cDNA disrupts viral replication pre/post-integration.Formula:C44H72N10O15Purezza:98%Colore e forma:SolidPeso molecolare:981.1HIV-IN-2
CAS:HIV-IN-2 (Compound 100) is a potent inhibitor of HIV, showing potential for research into HIV infection [1].Formula:C34H27ClF7N9O3SColore e forma:SolidPeso molecolare:810.14Cys-TAT(47-57)
CAS:Cys-TAT(47-57): arginine-rich peptide from HIV-1 TAT protein's transduction domain.Formula:C67H124N34O14SPurezza:98%Colore e forma:SolidPeso molecolare:1661.99NF279
CAS:P2X1 antagonistFormula:C49H36N6Na6O23S6Purezza:98%Colore e forma:SolidPeso molecolare:1407.17Delavirdine
CAS:Delavirdine, an NNRTI for HIV-1, is used in HAART.Formula:C22H28N6O3SColore e forma:SolidPeso molecolare:456.56Tenofovir-C3-O-C15-CF3 ammonium
CAS:Tenofovir-C3-O-C15-CF3 (ammonium) has a longer half-life and stronger anti-HIV action, improving pharmacokinetics in vivo.Formula:C28H52F3N6O5PColore e forma:SolidPeso molecolare:640.73Peptide T TFA
CAS:Peptide T (TFA), an octapeptide from HIV-1 gp120, inhibits HIV binding to CD4.Formula:C37H56F3N9O18Purezza:98%Colore e forma:SolidPeso molecolare:971.89IC-1k
IC-1k is an effective inhibitor of HIV-1, exhibiting anti-viral activity with EC50 values of 2.69 nM against HIV-1IIIB and 97.97 nM against HIV-2 ROD. Additionally, IC-1k has been noted to possess cytotoxic properties.Formula:C27H22F2N4O3SColore e forma:SolidPeso molecolare:520.55ELDKWA
CAS:ELDKWA, a highly conserved sequence of amino acids located on the ecto-domain of gp41, serves as the epitope for mAb 2F5, a neutralizing monoclonal antibodyFormula:C35H52N8O11Colore e forma:SolidPeso molecolare:760.83SPD-756
CAS:SPD-756, a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.Formula:C12H16N6O3Purezza:98%Colore e forma:SolidPeso molecolare:292.29HIV-1 protease-IN-14
HIV-1protease-IN-14 (compound 5ae) is an effective inhibitor of HIV-1protease, exhibiting Ki values of 0.28 nM and 56.9 nM against WTHIV-1PR and R41THIV-1PR, respectively. This compound also demonstrates low cytotoxicity.Colore e forma:Odour Solid
