CymitQuimica logo
Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1030 prodotti di "Segnalazione PI3K/Akt/mTOR"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • Logo CymitQuimica
    Targetmol
    + Info

    Timigutuzumab

    CAS:
    <p>Timigutuzumab (GEXMab73) is a humanized monoclonal antibody designed to target ErbB2, showing potential application in cancer research [1].</p>
    Colore e forma:Liquid

    Ref: TM-T76977

  • Logo CymitQuimica
    Targetmol
    + Info

    Anticancer agent 271

    <p>Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.</p>
    Colore e forma:Odour Solid

    Ref: TM-T206744

  • WAY-270360
    Targetmol
    + Info

    WAY-270360

    CAS:
    <p>WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.</p>
    Formula:C22H19N3O3
    Purezza:98.05%
    Colore e forma:Solid
    Peso molecolare:373.4

    Ref: TM-T60064

  • Logo CymitQuimica
    Targetmol
    + Info

    DSPE-PEG1000-GE11

    <p>DSPE-PEG1000-GE11 is a PEG compound made up of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells overexpressing EGFR. DSPE-PEG1000-GE11 serves a role in drug delivery.</p>
    Colore e forma:Odour Solid

    Ref: TM-TCL-01150

  • Logo CymitQuimica
    Targetmol
    + Info

    IHMT-PI3K-315

    IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.
    Formula:C22H20F2N6O4
    Colore e forma:Solid
    Peso molecolare:470.43

    Ref: TM-T200165

  • Logo CymitQuimica
    Targetmol
    + Info

    MS9427 TFA

    <p>MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.</p>
    Formula:C50H59ClF4N8O14
    Colore e forma:Solid
    Peso molecolare:1107.5

    Ref: TM-T74634

  • Varlitinib Tosylate
    Targetmol
    + Info

    Varlitinib Tosylate

    CAS:
    <p>Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).</p>
    Formula:C36H35ClN6O8S3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:811.34

    Ref: TM-T20954

  • RMC-4529
    Targetmol
    + Info

    RMC-4529

    CAS:
    <p>RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.</p>
    Formula:C90H139N13O23
    Colore e forma:Solid
    Peso molecolare:1771.17

    Ref: TM-T39776

  • Lyso-Monosialoganglioside GM3
    Targetmol
    + Info

    Lyso-Monosialoganglioside GM3

    CAS:
    <p>Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.</p>
    Formula:C41H74N2O20
    Colore e forma:Solid
    Peso molecolare:915.028

    Ref: TM-T206584

  • PROTAC EGFR degrader 10
    Targetmol
    + Info

    PROTAC EGFR degrader 10

    CAS:
    <p>PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.</p>
    Formula:C49H65ClN10O7S
    Colore e forma:Solid
    Peso molecolare:973.62

    Ref: TM-T88273

  • AZ14240475
    Targetmol
    + Info

    AZ14240475

    <p>AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.</p>
    Formula:C23H15ClF2N6O2
    Colore e forma:Solid
    Peso molecolare:480.854

    Ref: TM-T204475

  • Logo CymitQuimica
    Targetmol
    + Info

    GSK3β/mTOR modulator 1

    <p>GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.</p>
    Formula:C19H28O5
    Colore e forma:Solid
    Peso molecolare:336.19367

    Ref: TM-T207314

  • Logo CymitQuimica
    Targetmol
    + Info

    DSPE-PEG2000-GE11

    <p>DSPE-PEG2000-GE11 is a PEG compound composed of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells that overexpress EGFR. DSPE-PEG2000-GE11 is utilized in drug delivery.</p>
    Colore e forma:Odour Solid

    Ref: TM-TCL-01177

  • PI3K-IN-22
    Targetmol
    + Info

    PI3K-IN-22

    CAS:
    <p>PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.</p>
    Formula:C31H35F3N8O3
    Colore e forma:Solid
    Peso molecolare:624.66

    Ref: TM-T36087

  • Logo CymitQuimica
    Targetmol
    + Info

    OK2

    <p>OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2.</p>
    Formula:C42H62N14O9
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:907.03

    Ref: TM-T80220

  • PI3Kα-IN-25
    Targetmol
    + Info

    PI3Kα-IN-25

    <p>PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.</p>
    Formula:C21H19ClN4O4
    Colore e forma:Solid
    Peso molecolare:426.853

    Ref: TM-T205675

  • Umbralisib R-enantiomer
    Targetmol
    + Info

    Umbralisib R-enantiomer

    CAS:
    <p>Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.</p>
    Formula:C31H24F3N5O3
    Purezza:97.34%
    Colore e forma:Solid
    Peso molecolare:571.55

    Ref: TM-T13140

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR-TK-IN-5

    <p>EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.</p>
    Formula:C26H20ClFN4OS
    Colore e forma:Solid
    Peso molecolare:490.98

    Ref: TM-T205705

  • Phosphatidylinositol 4,5-bisphosphate
    Targetmol
    + Info

    Phosphatidylinositol 4,5-bisphosphate

    CAS:
    <p>Phosphatidylinositol 4,5-bisphosphate, a cell membrane phospholipid, is a PLC and PI3K substrate and a messenger.</p>
    Formula:C47H85O19P3
    Colore e forma:Solid
    Peso molecolare:1047.09

    Ref: TM-T73812

  • PF-06465603
    Targetmol
    + Info

    PF-06465603

    CAS:
    <p>PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.</p>
    Formula:C22H25N5O5
    Colore e forma:Solid
    Peso molecolare:439.46

    Ref: TM-T28373