Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

Mostrare 2 più sottocategorie

Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

Purezza (%)

100

prodotti per pagina.

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PI3-Kinase α Inhibitor 2 (hydrochloride)
CAS:
- 1188890-32-5
PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor.
Formula:C₁₆H₁₇Cl₂N₃O₂S
Colore e forma:Solid
Peso molecolare:386.3
Ref: TM-T35526
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Necitumumab
CAS:
- 906805-06-9
Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.
Purezza:97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)
Colore e forma:Liquid
Peso molecolare:145.5 kDa
Ref: TM-T77459
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ARUK2001607
CAS:
- 2924824-56-4
ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.
Formula:C₁₄H₁₃N₃O₂S₂
Purezza:99.75%
Colore e forma:Soild
Peso molecolare:319.40
Ref: TM-T67845
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PI3Kδ-IN-9
CAS:
- 2135922-40-4
PI3Kδ-IN-9 is a selective PI3Kδ inhibitor with an IC 50 value of 3.8 nM.
Formula:C₂₄H₂₆FN₉O
Colore e forma:Solid
Peso molecolare:475.532
Ref: TM-T39592
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HER2-IN-14
CAS:
- 2414056-35-0
HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.
Formula:C₂₆H₂₃ClF₂N₈O₃
Colore e forma:Solid
Peso molecolare:568.96
Ref: TM-T75165
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mTOR inhibitor 9e
CAS:
- 1144075-40-0
mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.
Formula:C₂₂H₂₃N₅O₂S
Purezza:98.84%
Colore e forma:Soild
Peso molecolare:421.52
Ref: TM-T67704
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OK2
OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2.
Formula:C₄₂H₆₂N₁₄O₉
Purezza:98%
Colore e forma:Solid
Peso molecolare:907.03
Ref: TM-T80220
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740 Y-P(TFA)
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.
Formula:C₁₄₃H₂₂₃F₃N₄₃O₄₁PS₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:3384.73
Ref: TM-TQ0003L
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Istiratumab
CAS:
- 1509928-04-4
Istiratumab (M-6495) is a bispecific antibody against IGF-1R/ErbB3 for cancer research, promoting receptor degradation.
Colore e forma:Liquid
Ref: TM-T77044
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Inetetamab
Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.
Purezza:96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)
Colore e forma:Odour Liquid
Ref: TM-T78335
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Amdizalisib
CAS:
- 1894229-05-0
Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.
Formula:C₁₉H₁₅ClN₈
Colore e forma:Solid
Peso molecolare:390.84
Ref: TM-T39327
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EGFR WT/T790M/L858R-IN-1
EGFRWT/T790M/L858R-IN-1 (compound 10d) is a potent inhibitor of EGFR, demonstrating IC50 values of 0.097, 0.280, and 0.051 μM for EGFRWT, EGFRT790M, and EGFRL858R, respectively. This compound can be utilized in cancer research.
Formula:C₂₆H₂₅Cl₃N₂O₃
Peso molecolare:518.09308
Ref: TM-T208869
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CN009543V
CAS:
- 375826-84-9
CN009543V is an enhancer of tyrosine phosphorylation of EGFR via downstream signaling pathways.
Formula:C₁₂H₁₂N₄O₆S
Colore e forma:Solid
Peso molecolare:340.31
Ref: TM-T30992
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740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-
Formula:C₁₄₃H₂₂₆N₄₃O₄₁PS₃
Purezza:99.92%
Colore e forma:Soild
Peso molecolare:3330.79
Ref: TM-TQ0003L1
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Tyrosine kinase-IN-7
CAS:
- 345615-74-9
Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity.
Formula:C₁₆H₁₅N₃OS
Purezza:99.93%
Colore e forma:Solid
Peso molecolare:297.38
Ref: TM-T77746
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EGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.
Formula:C₄₉H₅₃ClFN₅O₅
Colore e forma:Solid
Peso molecolare:846.43
Ref: TM-T74457
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GSK-3β inhibitor 1
CAS:
- 187325-53-7
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.
Formula:C₁₄H₁₀N₂O
Purezza:99.40%
Colore e forma:Solid
Peso molecolare:222.24
Ref: TM-T11467
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PI3Kδ-IN-8
CAS:
- 2101518-75-4
PI3Kδ-IN-8 is a powerful and specific oral inhibitor of PI3Kδ, exhibiting an IC50 of 3.3 nM.
Formula:C₂₈H₂₁F₂N₇O
Colore e forma:Solid
Peso molecolare:509.521
Ref: TM-T39542
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IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for
Formula:C₂₆H₂₁F₂N₇O₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:517.49
Ref: TM-T78836
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PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)
Formula:C₅₀H₄₆F₄N₈O₈S₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:1027.07
Ref: TM-T78853