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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1034 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • EGFR-IN-85
    Targetmol
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    EGFR-IN-85

    CAS:
    EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR
    Formula:C26H30N8O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:486.57

    Ref: TM-T78574

  • BRD5648
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    BRD5648

    CAS:
    BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.
    Formula:C20H23N3O
    Purezza:99.89%
    Colore e forma:Solid
    Peso molecolare:321.42

    Ref: TM-T10608

  • BPIQ-I
    Targetmol
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    BPIQ-I

    CAS:
    <p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>
    Formula:C16H12BrN5
    Colore e forma:Solid
    Peso molecolare:354.2

    Ref: TM-T70227

  • SU-11752
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    SU-11752

    CAS:
    SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.
    Formula:C26H27N3O5S
    Colore e forma:Solid
    Peso molecolare:493.57

    Ref: TM-T68870

  • PI5P4Kα-IN-1
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    PI5P4Kα-IN-1

    CAS:
    <p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>
    Formula:C20H17N3O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:363.43

    Ref: TM-T78178

  • SAR502250
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    SAR502250

    CAS:
    <p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>
    Formula:C19H18FN5O2
    Colore e forma:Solid
    Peso molecolare:367.38

    Ref: TM-T35560

  • HER2-IN-5
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Formula:C27H33N7O3
    Colore e forma:Solid
    Peso molecolare:503.6

    Ref: TM-T63432

  • Antitrypanosomal agent 14
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    Antitrypanosomal agent 14

    CAS:
    Antitrypanosomal agent 14 (Compound 1), a potent T.
    Formula:C14H23N3OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:281.42

    Ref: TM-T79254

  • PT-65
    Targetmol
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    PT-65

    CAS:
    <p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>
    Formula:C51H63N13O12S
    Colore e forma:Solid
    Peso molecolare:1082.19

    Ref: TM-T84913

  • Rheb inhibitor NR1
    Targetmol
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    Rheb inhibitor NR1

    CAS:
    <p>Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.</p>
    Formula:C25H19BrCl2N2O3S
    Purezza:99.72%
    Colore e forma:Solid
    Peso molecolare:578.3

    Ref: TM-T16741

  • PI3K-IN-54
    Targetmol
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    PI3K-IN-54

    CAS:
    <p>Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.</p>
    Formula:C20H24F2N8O3
    Purezza:98.15%
    Colore e forma:Solid
    Peso molecolare:462.45

    Ref: TM-T77771

  • EGFR/ErbB-2 inhibitor-1
    Targetmol
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Formula:C23H15ClFN3OS2
    Purezza:98.93%
    Colore e forma:Solid
    Peso molecolare:467.97

    Ref: TM-T79861

  • BGB-8035
    Targetmol
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    BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Formula:C24H31N5O4
    Purezza:96.74%
    Colore e forma:Solid
    Peso molecolare:453.53

    Ref: TM-T73381

  • Sevabertinib
    Targetmol
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    Sevabertinib

    CAS:
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Formula:C24H25ClN4O5
    Purezza:99.81%
    Colore e forma:Solid
    Peso molecolare:484.93

    Ref: TM-T200964

  • EGFR-IN-1 hydrochloride
    Targetmol
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    EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Formula:C28H31ClN6O4
    Purezza:99.16%
    Colore e forma:Solid
    Peso molecolare:551.04

    Ref: TM-T11157L

  • EGFR-IN-87
    Targetmol
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    EGFR-IN-87

    CAS:
    EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,
    Formula:C28H33N7O2
    Purezza:98.64%
    Colore e forma:Solid
    Peso molecolare:499.61

    Ref: TM-T79888

  • EGFR-IN-8
    Targetmol
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    EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Formula:C32H23ClF3N7O4
    Purezza:99.51%
    Colore e forma:Solid
    Peso molecolare:662.02

    Ref: TM-T11162

  • GSK-F1
    Targetmol
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    GSK-F1

    CAS:
    <p>GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.</p>
    Formula:C27H18F5N5O4S
    Purezza:97.03%
    Colore e forma:Solid
    Peso molecolare:603.52

    Ref: TM-T19840

  • PF-04979064
    Targetmol
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    PF-04979064

    CAS:
    <p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>
    Formula:C24H26N6O3
    Purezza:98.20% - ≥98%
    Colore e forma:Solid
    Peso molecolare:446.5

    Ref: TM-T7343

  • GSK-3 inhibitor 1
    Targetmol
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Formula:C22H17ClFN5O2
    Purezza:98.42%
    Colore e forma:Solid
    Peso molecolare:437.85

    Ref: TM-T11468