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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • GSK3β-IN-2
    Targetmol
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    GSK3β-IN-2

    CAS:
    GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.
    Formula:C25H18N4O
    Colore e forma:Solid
    Peso molecolare:390.437

    Ref: TM-T205461

  • LSD1/EGFR-IN-1
    Targetmol
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    LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Formula:C21H20ClN3O4
    Colore e forma:Solid
    Peso molecolare:413.854

    Ref: TM-T204471

  • Sacibertinib
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    Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Formula:C32H31ClN6O4
    Colore e forma:Solid
    Peso molecolare:599.08

    Ref: TM-T64225

  • 5-Bromo-3-indoxylacetate
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    5-Bromo-3-indoxylacetate

    CAS:
    <p>5-Bromo-3-indoxylacetate acts as an inhibitor of GSK-3, with a pIC50 value of 3.39.</p>
    Formula:C10H8BrNO2
    Colore e forma:Solid
    Peso molecolare:254.08

    Ref: TM-T205502

  • SST0116CL1
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    SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Formula:C22H31ClN4O6
    Colore e forma:Solid
    Peso molecolare:482.96

    Ref: TM-T200022

  • EGFR-IN-126
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    EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Formula:C28H28BrFN4O3
    Colore e forma:Solid
    Peso molecolare:567.45

    Ref: TM-T200496

  • ETP-47037
    Targetmol
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    ETP-47037

    CAS:
    <p>ETP-47037: strong PI3Kα inhibitor (IC50: 0.99 nM), also targets PI3Kβ, δ, γ; may protect telomeres.</p>
    Formula:C20H27N9O3S
    Colore e forma:Solid
    Peso molecolare:473.55

    Ref: TM-T63072

  • Tesevatinib tosylate
    Targetmol
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Formula:C31H33Cl2FN4O5S
    Colore e forma:Solid
    Peso molecolare:663.59

    Ref: TM-T201865

  • EGFR-IN-34
    Targetmol
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    EGFR-IN-34

    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Formula:C26H27ClN6O2
    Colore e forma:Solid
    Peso molecolare:490.98

    Ref: TM-T63300

  • PI3K-IN-26
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    PI3K-IN-26

    CAS:
    <p>PI3K-IN-26 is an effective PI3K inhibitor. PI3K-IN-26 inhibits the proliferation of SU-DHL-6 cells, IC50= 36 nM.</p>
    Formula:C21H18N6OS
    Colore e forma:Solid
    Peso molecolare:402.47

    Ref: TM-T61966

  • HER2-IN-7
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    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Formula:C28H26F3N7O3
    Colore e forma:Solid
    Peso molecolare:565.55

    Ref: TM-T64003

  • NS-062
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    NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Formula:C28H30Cl2F2N6O4
    Colore e forma:Solid
    Peso molecolare:623.48

    Ref: TM-T201773

  • EGFR-IN-160
    Targetmol
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    EGFR-IN-160

    CAS:
    EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).
    Formula:C15H12N2O4
    Colore e forma:Solid
    Peso molecolare:284.27

    Ref: TM-T207600

  • PI4KIII β inhibitor 5
    Targetmol
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    PI4KIII β inhibitor 5

    CAS:
    <p>PI4KIII beta inhibitor 5 (Compound 43) is an inhibitor of PI4KIIIβ with an IC50 of 19 nM. By inhibiting the PI3K/AKT pathway, it induces apoptosis in cancer cells, causes cell cycle arrest at the G2/M phase, and promotes autophagy. Additionally, PI4KIII beta inhibitor 5 demonstrates significant anti-tumor activity in the H446 small cell lung cancer xenograft model. This compound is applicable in cancer research studies.</p>
    Formula:C24H27F2N3O4S2
    Colore e forma:Solid
    Peso molecolare:523.616

    Ref: TM-T206518

  • PI3K-IN-27
    Targetmol
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    PI3K-IN-27

    CAS:
    <p>PI3K-IN-27 is a potent PI3K inhibitor, relevant for cancer and immune disease research. See patent WO2021233227A1.</p>
    Formula:C30H26F2N6O2S
    Colore e forma:Solid
    Peso molecolare:572.63

    Ref: TM-T64052

  • Logo CymitQuimica
    Targetmol
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    DNA-PK-IN-9

    <p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>
    Formula:C21H21N5O2
    Colore e forma:Solid
    Peso molecolare:375.42

    Ref: TM-T61533

  • HER2-IN-21
    Targetmol
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    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formula:C20H18N4O3S
    Colore e forma:Solid
    Peso molecolare:394.447

    Ref: TM-T205331

  • GSK-3β inhibitor 26
    Targetmol
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    GSK-3β inhibitor 26

    CAS:
    <p>GSK-3β inhibitor26 (Compound D14) is a GSK-3β inhibitor with an IC50 of 18.23 μM. This compound is applicable in research related to cancer, inflammation, and neurodegenerative diseases.</p>
    Formula:C15H11N3O3
    Colore e forma:Solid
    Peso molecolare:281.266

    Ref: TM-T205441

  • EGFR-IN-147
    Targetmol
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    EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Formula:C13H13N5O
    Colore e forma:Solid
    Peso molecolare:255.275

    Ref: TM-T204935

  • DNA-PK-IN-15
    Targetmol
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    DNA-PK-IN-15

    CAS:
    DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.
    Formula:C23H23N9O
    Colore e forma:Solid
    Peso molecolare:441.49

    Ref: TM-T201160