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Segnalazione PI3K/Akt/mTOR

Segnalazione PI3K/Akt/mTOR

Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.

Sottocategorie di "Segnalazione PI3K/Akt/mTOR"

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Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"

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  • HER2-IN-6
    Targetmol
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    HER2-IN-6

    CAS:
    <p>HER2-IN-6, a potent HER2 inhibitor, may target wild/mutant EGFR and HER2-mediated tumors. (Patent WO2021164697A1, compound 11)</p>
    Formula:C26H32N8O3
    Colore e forma:Solid
    Peso molecolare:504.58

    Ref: TM-T63441

  • JBJ-09-063
    Targetmol
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    JBJ-09-063

    CAS:
    <p>JBJ-09-063: EGFR inhibitor, IC50s 0.147-0.396 nM for various mutants; hinders EGFR/Akt/ERK1/2 phosphorylation; targets TKI-sensitive/resistant lung cancer.</p>
    Formula:C31H29FN4O3S
    Colore e forma:Solid
    Peso molecolare:556.65

    Ref: TM-T63939

  • Logo CymitQuimica
    Targetmol
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    EGFR/HER2-IN-7

    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Formula:C19H21N3O2S
    Colore e forma:Solid
    Peso molecolare:355.45

    Ref: TM-T61272

  • PI3kδ inhibitor 1
    Targetmol
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    PI3kδ inhibitor 1

    CAS:
    <p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>
    Formula:C28H33FN6O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:504.60

    Ref: TM-T12463

  • PI3Kβ-IN-1
    Targetmol
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    PI3Kβ-IN-1

    CAS:
    <p>PI3Kβ-IN-1 is a selective, orally active PI3Kβ inhibitor (IC50: 2 nM).</p>
    Formula:C25H14F2N8
    Colore e forma:Solid
    Peso molecolare:464.43

    Ref: TM-T62948

  • EGFR-IN-130
    Targetmol
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    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Formula:C27H25N3O6S
    Colore e forma:Solid
    Peso molecolare:519.57

    Ref: TM-T201686

  • EGFR-IN-35
    Targetmol
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    EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Formula:C25H24ClN7O2
    Colore e forma:Solid
    Peso molecolare:489.96

    Ref: TM-T63282

  • Logo CymitQuimica
    Targetmol
    + Info

    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Formula:C16H16N4O2S
    Colore e forma:Solid
    Peso molecolare:328.39

    Ref: TM-T60938

  • EGFR/VEGFR2-IN-2
    Targetmol
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    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Formula:C24H15FO3
    Colore e forma:Solid
    Peso molecolare:370.37

    Ref: TM-T201505

  • GSK-3β inhibitor 20
    Targetmol
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    GSK-3β inhibitor 20

    CAS:
    <p>GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.</p>
    Formula:C22H21N5O2S
    Colore e forma:Solid
    Peso molecolare:419.50

    Ref: TM-T200457

  • Logo CymitQuimica
    Targetmol
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    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Colore e forma:Solid

    Ref: TM-T64254

  • Neptinib
    Targetmol
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    Neptinib

    CAS:
    <p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>
    Formula:C22H23ClFN5O2
    Colore e forma:Solid
    Peso molecolare:443.90

    Ref: TM-T89923

  • JBJ-02-112-05
    Targetmol
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    JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Formula:C27H20N4O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:464.54

    Ref: TM-T11713

  • HER2-IN-8
    Targetmol
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Colore e forma:Solid
    Peso molecolare:549.53

    Ref: TM-T63881

  • Vulolisib
    Targetmol
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    Vulolisib

    CAS:
    <p>Vulolisib inhibits PI3K (α: IC50 0.2nM, β: 168nM, γ: 90nM, δ: 49nM), taken orally with anti-cancer properties.</p>
    Formula:C18H19F2N5O3S
    Colore e forma:Solid
    Peso molecolare:423.44

    Ref: TM-T62273

  • GSK3β-IN-1
    Targetmol
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    GSK3β-IN-1

    CAS:
    <p>GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.</p>
    Formula:C17H13FN2O4S
    Colore e forma:Solid
    Peso molecolare:360.36

    Ref: TM-T204474

  • EGFR-IN-139
    Targetmol
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formula:C27H25ClN2O4
    Colore e forma:Solid
    Peso molecolare:476.951

    Ref: TM-T204772

  • PD-M6
    Targetmol
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    PD-M6

    CAS:
    <p>PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.</p>
    Formula:C30H39N9O6
    Colore e forma:Solid
    Peso molecolare:621.69

    Ref: TM-T207406

  • EGFR-IN-38
    Targetmol
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    EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Formula:C25H24ClN7O2
    Colore e forma:Solid
    Peso molecolare:489.96

    Ref: TM-T63283

  • EGFR-IN-125
    Targetmol
    + Info

    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Formula:C30H26N8O
    Colore e forma:Solid
    Peso molecolare:514.58

    Ref: TM-T204450