Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(159 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(50 prodotti)
- EGFR(572 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(241 prodotti)
- Chinasi S6(9 prodotti)
- gsk-3(111 prodotti)
- mTOR(145 prodotti)
Mostrare 2 più sottocategorie
Trovati 1025 prodotti di "Segnalazione PI3K/Akt/mTOR"
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AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Formula:C21H23N7O3SPurezza:98% - 99.25%Colore e forma:SolidPeso molecolare:453.52MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:314.38KY19382
CAS:<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formula:C17H11Cl2N3O2Purezza:98.06%Colore e forma:SolidPeso molecolare:360.19Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Formula:C21H16FN7OPurezza:98.99% - ≥95%Colore e forma:SolidPeso molecolare:401.4Desmethyl Erlotinib
CAS:<p>Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).</p>Formula:C21H21N3O4Purezza:97.92% - 98.62%Colore e forma:SolidPeso molecolare:379.41Osimertinib
CAS:Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formula:C28H33N7O2Purezza:99.32% - >99.99%Colore e forma:SolidPeso molecolare:499.61RG13022
CAS:<p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>Formula:C16H14N2O2Purezza:98.38%Colore e forma:SolidPeso molecolare:266.29Nazartinib
CAS:<p>Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (</p>Formula:C26H31ClN6O2Purezza:98.63% - ≥95%Colore e forma:Solid PowderPeso molecolare:495.02NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFormula:C17H15NO3Purezza:99.51% - >99.99%Colore e forma:SolidPeso molecolare:281.31PF-6274484
CAS:<p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>Formula:C18H14ClFN4O2Purezza:97.71%Colore e forma:SolidPeso molecolare:372.78Gefitinib-based PROTAC 3
CAS:<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Formula:C47H57ClFN7O8SPurezza:97.29% - 98.25%Colore e forma:SolidPeso molecolare:934.51WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purezza:99.21%Colore e forma:SolidPeso molecolare:297.31Dacomitinib hydrate
CAS:<p>Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of</p>Formula:C24H27ClFN5O3Purezza:99.52%Colore e forma:SolidPeso molecolare:487.96Almonertinib
CAS:<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>Formula:C30H35N7O2Purezza:99.99%Colore e forma:SolidPeso molecolare:525.64WS6
CAS:<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formula:C29H31F3N6O3Purezza:97.65% - 99.95%Colore e forma:SolidPeso molecolare:568.59Vacuolin-1
CAS:<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formula:C26H24IN7OPurezza:97.20% - 98.45%Colore e forma:SolidPeso molecolare:577.42Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formula:C29H31Cl2FN4OColore e forma:SolidPeso molecolare:541.49HG-9-91-01
CAS:<p>HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and</p>Formula:C32H37N7O3Purezza:96.86% - 99.71%Colore e forma:SolidPeso molecolare:567.68Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Formula:C30H29ClN6O3Purezza:96.17% - 99.85%Colore e forma:SolidPeso molecolare:557.04AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formula:C18H20N8O2Purezza:99.03% - 99.85%Colore e forma:SolidPeso molecolare:380.4TAS6417
CAS:<p>Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formula:C23H20N6OPurezza:99.71%Colore e forma:SolidPeso molecolare:396.44RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formula:C25H24N4O2Purezza:98.19% - 98.75%Colore e forma:Orange SolidPeso molecolare:412.48WHI-P154
CAS:<p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>Formula:C16H14BrN3O3Purezza:98% - 99.67%Colore e forma:SolidPeso molecolare:376.2AZD8931 diFuMaric acid
CAS:<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Formula:C31H33ClFN5O11Purezza:99.92%Colore e forma:SolidPeso molecolare:706.1GDC-0326
CAS:<p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>Formula:C19H22N6O3Purezza:99.35% - >99.99%Colore e forma:SolidPeso molecolare:382.42G5-7
CAS:<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39Osimertinib mesylate
CAS:<p>Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.</p>Formula:C29H37N7O5SPurezza:99.46% - >99.99%Colore e forma:SolidPeso molecolare:595.71TMBIM6 antagonist-1
CAS:<p>TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor</p>Formula:C15H12N2O3Purezza:99.26%Colore e forma:SolidPeso molecolare:268.27NIBR-17
CAS:<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Formula:C18H20N8O2Purezza:97.79%Colore e forma:SolidPeso molecolare:380.4AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Formula:C16H12N2O3Purezza:98.69%Colore e forma:SolidPeso molecolare:280.28AS-041164
CAS:<p>AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.</p>Formula:C11H7NO4SPurezza:99.45%Colore e forma:SolidPeso molecolare:249.24RG14620
CAS:<p>RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.</p>Formula:C14H8Cl2N2Purezza:99.82% - 99.87%Colore e forma:SolidPeso molecolare:275.13AZD8186
CAS:<p>AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).</p>Formula:C24H25F2N3O4Purezza:99.89% - 99.91%Colore e forma:SolidPeso molecolare:457.47Zotarolimus
CAS:<p>Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).</p>Formula:C52H79N5O12Purezza:95% - 98.01%Colore e forma:SolidPeso molecolare:966.21CZC24832
CAS:<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Formula:C15H17FN6O2SPurezza:99.08% - 99.12%Colore e forma:SolidPeso molecolare:364.4Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purezza:98.3% - 99.33%Colore e forma:SolidPeso molecolare:607.62DMNB
CAS:<p>DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.</p>Formula:C9H9NO5Purezza:97.87%Colore e forma:Yellow SolidPeso molecolare:211.17Allitinib tosylate
CAS:<p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>Formula:C31H26ClFN4O5SPurezza:98.46% - 98.68%Colore e forma:SolidPeso molecolare:621.08PD-089828
CAS:<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formula:C18H18Cl2N6OPurezza:97.39%Colore e forma:SolidPeso molecolare:405.28PF-04802367
CAS:<p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>Formula:C16H16ClN5O3Purezza:98.76%Colore e forma:SolidPeso molecolare:361.78Avitinib
CAS:<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Formula:C26H26FN7O2Purezza:99.81% - >99.99%Colore e forma:SolidPeso molecolare:487.53AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3CZ415
CAS:<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Formula:C22H29N5O4SPurezza:97.54% - 98.36%Colore e forma:SolidPeso molecolare:459.56Linperlisib
CAS:<p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>Formula:C28H37FN6O5SPurezza:99.01%Colore e forma:SolidPeso molecolare:588.69GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formula:C25H27FN6O4Purezza:98.68% - 99.40%Colore e forma:SolidPeso molecolare:494.52VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Formula:C17H22N8OPurezza:97.82% - 99.54%Colore e forma:SolidPeso molecolare:354.41(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formula:C14H10N2OPurezza:98.60%Colore e forma:SolidPeso molecolare:222.24AG 555
CAS:<p>AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.</p>Formula:C19H18N2O3Purezza:98.02% - 99.94%Colore e forma:SolidPeso molecolare:322.36ASP4132
CAS:<p>ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.</p>Formula:C46H51F3N6O8S2Purezza:98.34%Colore e forma:SolidPeso molecolare:937.06
