Segnalazione PI3K/Akt/mTOR
Gli inibitori della segnalazione PI3K/Akt/mTOR sono composti che bersagliano le vie della fosfoinositide 3-chinasi (PI3K), della chinasi Akt e del bersaglio della rapamicina nei mammiferi (mTOR). Queste vie sono regolatori critici della crescita cellulare, della sopravvivenza, del metabolismo e dell'autofagia, rendendole bersagli chiave nella ricerca sul cancro e nei disturbi metabolici. Inibendo queste vie è possibile aiutare a controllare la crescita e la proliferazione tumorale, offrendo potenziali strategie terapeutiche per vari tipi di cancro e altre malattie caratterizzate da una segnalazione cellulare disfunzionale. Presso CymitQuimica, offriamo una vasta selezione di inibitori PI3K/Akt/mTOR di alta qualità per supportare la tua ricerca in oncologia, segnalazione cellulare e malattie metaboliche.
Sottocategorie di "Segnalazione PI3K/Akt/mTOR"
- AMPK(163 prodotti)
- ATM/ATR(71 prodotti)
- DNA-PK(49 prodotti)
- EGFR(592 prodotti)
- MELK(7 prodotti)
- PDK(9 prodotti)
- PI3K(238 prodotti)
- Chinasi S6(8 prodotti)
- gsk-3(111 prodotti)
- mTOR(152 prodotti)
Mostrare 2 più sottocategorie
Trovati 1034 prodotti di "Segnalazione PI3K/Akt/mTOR"
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BPIQ-II (hydrochloride)
CAS:BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Formula:C15H11BrClN5Colore e forma:SolidPeso molecolare:376.64FD2056
CAS:<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formula:C23H17ClN6O2SPurezza:98%Colore e forma:SolidPeso molecolare:476.94EMI56
CAS:EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].Formula:C21H20N2O3Colore e forma:SolidPeso molecolare:348.4EGFR-IN-39
CAS:EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Formula:C24H25ClN6O3Colore e forma:SolidPeso molecolare:480.95PF-06672131
CAS:PF-06672131 is a selective EGFR kinase inhibitor.Formula:C23H21ClFN5O2Colore e forma:SolidPeso molecolare:453.9PI5P4Ks-IN-1
CAS:<p>PI5P4Ks-IN-1 (compound 7) is an active compound which engages PI5P4Kγ[1].</p>Formula:C20H17N3SColore e forma:SolidPeso molecolare:331.43PI3K-IN-2
CAS:PI3K-IN-2 inhibits PI3Kβ/δ (IC50: 7.1, 8.6 nM) with greater selectivity over PI3Kσ/γ (IC50: 13, 190 nM) and is orally active.Formula:C28H29F2N3O5Colore e forma:SolidPeso molecolare:525.54NVP-BBD130
CAS:NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.Formula:C28H21N5OColore e forma:SolidPeso molecolare:443.5SIC-19
CAS:SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib).Formula:C29H26N4O5S2Colore e forma:SolidPeso molecolare:574.67DNA-PK-IN-7
CAS:DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).Formula:C19H21N9O2Colore e forma:SolidPeso molecolare:407.43EGFR-IN-89
CAS:<p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>Formula:C26H31FN8O2SPurezza:98%Colore e forma:SolidPeso molecolare:538.64EGFR-IN-31
CAS:<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Formula:C32H36FN7O2Colore e forma:SolidPeso molecolare:569.67TWS-119
CAS:TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.Formula:C22H16F6N4O6Colore e forma:SolidPeso molecolare:546.38EGFR mutant-IN-2
CAS:<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formula:C27H27F3N6O2SColore e forma:SolidPeso molecolare:556.6EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formula:C25H17ClN4O3SPeso molecolare:488.95P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormula:C9H8ClN3OPurezza:99.98%Colore e forma:SolidPeso molecolare:209.63SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Formula:C31H31FN8O3Colore e forma:SolidPeso molecolare:582.63EGFR-IN-69
CAS:EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formula:C31H37Cl2N7O3SColore e forma:SolidPeso molecolare:658.64Gefitinib N-oxide
CAS:Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formula:C22H24ClFN4O4Purezza:98%Colore e forma:SolidPeso molecolare:462.9BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Formula:C20H20F3N3OPurezza:98%Colore e forma:SolidPeso molecolare:375.39EGFR-IN-54
CAS:EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formula:C17H14N4O4S3Colore e forma:SolidPeso molecolare:434.51EGFR-IN-25
CAS:EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formula:C34H43N9O2Colore e forma:SolidPeso molecolare:609.76JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Formula:C31H30ClFN4O3SColore e forma:SolidPeso molecolare:593.11EGFR/HER2-IN-2
CAS:EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Formula:C26H23N5O3Colore e forma:SolidPeso molecolare:453.49Aloisine B
CAS:<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formula:C15H14ClN3Purezza:95.15%Colore e forma:SolidPeso molecolare:271.74EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formula:C19H15N3O2SPurezza:99.94%Colore e forma:SolidPeso molecolare:349.41GLPG3970
CAS:GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.Formula:C25H27F3N4O4Purezza:99.60% - >99.99%Colore e forma:SolidPeso molecolare:504.5Cazpaullone
CAS:<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Formula:C16H10N4OColore e forma:SolidPeso molecolare:274.28Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formula:C29H35FN8O3Purezza:98%Colore e forma:SolidPeso molecolare:562.64PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formula:C20H13ClF2N4O4SPurezza:96.16%Colore e forma:SolidPeso molecolare:478.86VP3.15
CAS:VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).Formula:C20H22N4OSPurezza:98%Colore e forma:SolidPeso molecolare:366.483,5-dimethyl PIT-1
CAS:<p>PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as</p>Formula:C16H15N3O4SColore e forma:SolidPeso molecolare:345.37PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Formula:C27H38N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:558.69Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formula:C31H29FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:508.59EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formula:C36H44BrN10O2PColore e forma:SolidPeso molecolare:759.68PP30
CAS:PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.Formula:C18H19N7OSPurezza:98%Colore e forma:SolidPeso molecolare:381.45mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formula:C23H21N7OPurezza:98%Colore e forma:SolidPeso molecolare:411.46PI3K-IN-6
CAS:PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).Formula:C17H14Cl2FN9OPurezza:98%Colore e forma:SolidPeso molecolare:450.26PI3Ka-IN-5
CAS:PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .Formula:C30H35N9O5Colore e forma:SolidPeso molecolare:601.66NVP-CLR457
CAS:NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.Formula:C18H20F3N7O4Colore e forma:SolidPeso molecolare:455.39PI3K/mTOR Inhibitor-13
CAS:PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.Formula:C20H13F2N5O3SColore e forma:SolidPeso molecolare:441.41JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Formula:C17H14Cl2FN3OSPurezza:98.33% - 98.33%Colore e forma:SolidPeso molecolare:398.28PI3K/mTOR Inhibitor-8
CAS:PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.Formula:C23H22N8O4SColore e forma:SolidPeso molecolare:506.54NVS-PI3-4
CAS:NVS-PI3-4: A selective PI3Kγ inhibitor for research in allergies, inflammation, and cancer.Formula:C20H26N4O3SColore e forma:SolidPeso molecolare:402.51JNJ28871063 hydrochloride
CAS:<p>ErbB receptor family inhibitor</p>Formula:C24H28Cl2N6O3Purezza:98%Colore e forma:SolidPeso molecolare:519.42EGFR-IN-68
CAS:<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formula:C24H22N2OColore e forma:SolidPeso molecolare:354.44(E/Z)-CP-724714
CAS:<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Formula:C27H27N5O3Purezza:98%Colore e forma:SolidPeso molecolare:469.54PI3Kα/mTOR-IN-1
CAS:<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Formula:C16H18N6OPurezza:99.89%Colore e forma:SolidPeso molecolare:310.3518BIOder
CAS:18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Formula:C9H7ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:210.62SDZ281-977
CAS:<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Formula:C18H20O5Purezza:99.64%Colore e forma:SolidPeso molecolare:316.35
