AMPK
Gli inibitori di AMPK sono composti che inibiscono la Proteina Chinasi Attivata da AMP (AMPK), un enzima che svolge un ruolo critico nell'omeostasi energetica cellulare. AMPK si attiva in risposta a bassi livelli di energia nelle cellule e aiuta a regolare processi come l'assorbimento del glucosio, l'ossidazione degli acidi grassi e la biogenesi mitocondriale. Inibire AMPK è importante per studiare il suo ruolo nelle malattie metaboliche, nel cancro e nell'invecchiamento. Presso CymitQuimica, offriamo una gamma di inibitori di AMPK per supportare la tua ricerca in metabolismo, oncologia e malattie legate all'età.
Trovati 168 prodotti di "AMPK"
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NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formula:C25H30N6OColore e forma:SolidPeso molecolare:430.545Anti-Phospho-AMPKα (Thr172) Antibody (3O988)
Anti-Phospho-AMPKα (Thr172) Antibody (3O988) is a Rabbit antibody targeting Phospho-AMPKα (Thr172). Anti-Phospho-AMPKα (Thr172) Antibody (3O988) can be used in WB.Colore e forma:Odour LiquidMetformin-d6 hydrochloride
CAS:Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.Formula:C4H12ClN5Purezza:98.1%Colore e forma:SolidPeso molecolare:171.666-Azuridine
CAS:<p>6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.</p>Formula:C8H11N3O6Purezza:>99.99%Colore e forma:SolidPeso molecolare:245.19Pyraclostrobin (Standard)
CAS:Pyraclostrobin (Standard) is the standard substance of Pyraclostrobin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.Formula:C19H18ClN3O4Peso molecolare:387.82Teneligliptin hydrobromide hydrate
CAS:Teneligliptin hydrobromide hydrate: potent, long-lasting DPP-4 inhibitor with ~1 nM IC50.Formula:C22H33BrN6O2SColore e forma:SolidPeso molecolare:525.51COH-SR4
CAS:<p>COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.</p>Formula:C13H8Cl4N2OPurezza:98.96%Colore e forma:SolidPeso molecolare:350.03Platycodin D
CAS:<p>Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.</p>Formula:C57H92O28Purezza:99.2% - 99.65%Colore e forma:SolidPeso molecolare:1225.32IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purezza:97.73%Colore e forma:SolidPeso molecolare:485.45O-304
CAS:O-304 is a pan-activator of AMP-activated protein kinase (AMPK).Formula:C16H11Cl2N3O2SPurezza:99.84% - ≥98%Colore e forma:SolidPeso molecolare:380.25Vaccarin
CAS:Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Formula:C32H38O19Purezza:99.16% - 99.97%Colore e forma:SolidPeso molecolare:726.63Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFormula:C19H18NO4Purezza:98.08% - 99.18%Colore e forma:SolidPeso molecolare:324.35GSK621
CAS:<p>GSK621 is a specific and potent AMPK activator.</p>Formula:C26H20ClN3O5Purezza:97.02% - 97.05%Colore e forma:SolidPeso molecolare:489.91Metformin
CAS:<p>Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.</p>Formula:C4H11N5Purezza:99.77% - >99.99%Colore e forma:SolidPeso molecolare:129.16DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Formula:C19H23N3O6S2Purezza:96.96% - 99.28%Colore e forma:SolidPeso molecolare:453.53Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFormula:C21H24O10Purezza:97.16%Colore e forma:SolidPeso molecolare:436.41ARN-3236
CAS:ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nMFormula:C19H16N2O2SPurezza:98.89% - 99.7%Colore e forma:SolidPeso molecolare:336.41STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formula:C19H10N2O3Purezza:97.14% - 98.8%Colore e forma:SolidPeso molecolare:314.29WH-4-025
CAS:<p>WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.</p>Formula:C39H38F3N7O5Purezza:99.41%Colore e forma:SolidPeso molecolare:741.76AMAROGENTIN
CAS:Amarogentin, extracted from Swertia/Gentiana roots, aids liver cancer prevention/treatment by affecting cell cycle and apoptosis.Formula:C29H30O13Purezza:99.98% - ≥95%Colore e forma:SolidPeso molecolare:586.54EB-3D
CAS:EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.Formula:C30H36Br2N4O2Purezza:99.48%Colore e forma:SolidPeso molecolare:644.4AMPK activator 2
CAS:AMPK activator 2, a chloroformin derivative, may boost cancer treatment by enhancing AMPK and inhibiting mTOR pathways, and cancer cell growth.Formula:C13H18F3N5Purezza:99.86%Colore e forma:SolidPeso molecolare:301.31BC1618
CAS:<p>BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.</p>Formula:C24H24F3NO2Purezza:99.95%Colore e forma:SolidPeso molecolare:415.45Pyraclostrobin
CAS:Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.Formula:C19H18ClN3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:387.82Buformin
CAS:Buformin, a biguanide oral antidiabetic, inhibits liver glucose production and improves insulin sensitivity.Formula:C6H15N5Colore e forma:SolidPeso molecolare:157.22Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purezza:99.71% - 99.98%Colore e forma:White PowderPeso molecolare:440.40MK-3903
CAS:MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).Formula:C27H19ClN2O3Purezza:98.63% - 99.75%Colore e forma:SolidPeso molecolare:454.9IMT1
CAS:IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.Formula:C21H21NO4Purezza:98.07% - 98.14%Colore e forma:SolidPeso molecolare:351.4Kahweol
CAS:Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaBFormula:C20H26O3Purezza:99.26% - 99.86%Colore e forma:Off-White To Yellow SolidPeso molecolare:314.42Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity onFormula:C24H25N5O·2HClPurezza:97.74% - 99.89%Colore e forma:SolidPeso molecolare:472.41WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Formula:C25H29ClN6O3Purezza:99.65% - >99.99%Colore e forma:SolidPeso molecolare:496.99Marein
CAS:Marein prevents PC12 cell damage by protecting mitochondria and activating AMPK, potentially countering diabetic encephalopathy.Formula:C21H22O11Purezza:99.12% - 99.84%Colore e forma:SolidPeso molecolare:450.39Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purezza:97.47% - 99.8%Colore e forma:SolidPeso molecolare:178.14Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurezza:98% - 99.06%Colore e forma:SolidPeso molecolare:399.49Bempedoic acid
CAS:<p>Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C.</p>Formula:C19H36O5Purezza:99.85% - 99.94%Colore e forma:SolidPeso molecolare:344.49Mogroside I E1
CAS:Mogroside I E1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener.Formula:C36H62O9Purezza:98.62% - 99.71%Colore e forma:SolidPeso molecolare:638.87Teneligliptin hydrobromide
CAS:Teneligliptin hydrobromide: potent, novel DPP-4 inhibitor; inhibits human/rat plasma DPP-4 with ~1 nM IC50.Formula:C22H30N6OSBrHPurezza:97.83% - 99.92%Colore e forma:SolidPeso molecolare:628.86Flurbiprofen Axetil
CAS:Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.Formula:C19H19FO4Purezza:97.58% - 98%Colore e forma:SolidPeso molecolare:330.35STF-118804
CAS:STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Formula:C25H23N3O4SPurezza:98.66%Colore e forma:SolidPeso molecolare:461.53SBI-0206965
CAS:<p>SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.</p>Formula:C21H21BrN4O5Purezza:99.13%Colore e forma:SolidPeso molecolare:489.32Gomisin J
CAS:Gomisin J is a natural product and have vasodilatory activity.Formula:C22H28O6Purezza:99.59% - 99.60%Colore e forma:SolidPeso molecolare:388.45GSK-690693
CAS:GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.Formula:C21H27N7O3Purezza:98.07% - 99.77%Colore e forma:SolidPeso molecolare:425.48RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purezza:99.30%Colore e forma:SolidPeso molecolare:312.37Nepodin
CAS:Nepodin exhibits antimalarial, anti-inflammatory, and antidiabetic effects by inhibiting COX and activating AMPK to stimulate GLUT4.Formula:C13H12O3Purezza:97.9% - 99.12%Colore e forma:SolidPeso molecolare:216.23PKC-iota inhibitor 1
CAS:<p>PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)</p>Formula:C21H22N6OPurezza:98.82%Colore e forma:SolidPeso molecolare:374.44MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formula:C26H37ClN6O2Purezza:98.19%Colore e forma:SolidPeso molecolare:501.07ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Formula:C24H27N7OPurezza:99.53% - 99.7%Colore e forma:SolidPeso molecolare:429.52Metformin glycinate
CAS:Metformin glycinate activates AMPK, enhances insulin sensitivity, and reduces glucose absorption for better glycemic control.Formula:C6H16N6O2Colore e forma:SolidPeso molecolare:204.23[6]-Gingerol
CAS:[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for tumors.Formula:C17H26O4Purezza:98% - 99.66%Colore e forma:Light Yellow OilinessPeso molecolare:294.39Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Formula:C16H30O2Purezza:99.76%Colore e forma:SolidPeso molecolare:254.41
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