PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 231 prodotti di "PI3K"
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RLY-2608
CAS:RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.Formula:C29H14ClF5N6O2Purezza:98.62% - 98.7%Colore e forma:SolidPeso molecolare:608.91BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .Formula:C28H25F3N6O2·C4H4O4Purezza:97.75% - 98.77%Colore e forma:SolidPeso molecolare:650.6Ref: TM-T6072
1mg35,00€5mg73,00€1mL*10mM (DMSO)94,00€10mg108,00€25mg230,00€50mg339,00€100mg485,00€200mg665,00€GSK2292767
CAS:GSK2292767 is a potent and selective PI3Kδ inhibitor.Formula:C24H28N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:512.58CNX-1351
CAS:CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.Formula:C30H35N7O3SPurezza:99.66% - 99.83%Colore e forma:SolidPeso molecolare:573.71AZ2
CAS:AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.Formula:C20H23N3O2SPurezza:99.25% - 99.51%Colore e forma:SolidPeso molecolare:369.48Ref: TM-T36309
1mg94,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.674,00€CAL-130
CAS:CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:426.47PI3Kα-IN-13
CAS:PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,Formula:C21H19N5O3Purezza:98%Colore e forma:SolidPeso molecolare:389.41PI3K-IN-6
CAS:PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).Formula:C17H14Cl2FN9OPurezza:98%Colore e forma:SolidPeso molecolare:450.26FD2056
CAS:FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.Formula:C23H17ClN6O2SPurezza:98%Colore e forma:SolidPeso molecolare:476.94Nemiralisib
CAS:Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.Formula:C26H28N6OPurezza:99.91%Colore e forma:SolidPeso molecolare:440.54PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Formula:C27H38N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:558.69PI3K-IN-9
CAS:PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).Formula:C19H23N7OPurezza:98%Colore e forma:SolidPeso molecolare:365.43AZD3458
CAS:AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).Formula:C20H23N3O4S2Colore e forma:SolidPeso molecolare:433.54CAL-130 Hydrochloride
CAS:CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H23ClN8OColore e forma:SolidPeso molecolare:462.94PI3Kγ inhibitor 7
CAS:PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].Formula:C31H25N9O2Purezza:98%Colore e forma:SolidPeso molecolare:555.59CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Formula:C21H24ClN5O3S2Purezza:99.16%Colore e forma:SolidPeso molecolare:494.03Ref: TM-T10804
1mg96,00€5mg205,00€1mL*10mM (DMSO)224,00€10mg313,00€25mg562,00€50mg845,00€100mg1.153,00€PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Formula:C20H24N6O2Purezza:99.89%Colore e forma:SolidPeso molecolare:380.44Vps34-IN-2
CAS:Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).Formula:C18H25F3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:402.41PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Formula:C32H26N8O2SPurezza:98%Colore e forma:SolidPeso molecolare:586.67PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Formula:C28H24N6O3Purezza:99.8%Colore e forma:SolidPeso molecolare:492.53
