ATM/ATR
Gli inibitori di ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) prendono di mira chinasi chiave coinvolte nella risposta al danno al DNA (DDR) che vengono attivate in risposta a rotture del doppio filamento di DNA e stress da replicazione. Questi inibitori interrompono la capacità di queste chinasi di rilevare e riparare i danni al DNA, il che può portare a un aumento dell'instabilità genomica e alla morte cellulare, in particolare nelle cellule tumorali che dipendono da robusti meccanismi di riparazione del DNA per sopravvivere. Gli inibitori di ATM/ATR sono strumenti cruciali nella ricerca e nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una vasta gamma di inibitori di ATM/ATR di alta qualità per supportare la tua ricerca sulla risposta al danno al DNA, la biologia del cancro e lo sviluppo terapeutico.
Trovati 71 prodotti per "ATM/ATR".
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ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formula:C19H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:378.43ATM-IN-1
CAS:ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.Formula:C30H36N6O3Colore e forma:SolidPeso molecolare:528.65ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormula:C25H31N7OPurezza:98%Colore e forma:SolidPeso molecolare:445.56(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Formula:C20H24N6O2SColore e forma:SolidPeso molecolare:412.51ATR-IN-6
CAS:ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.Formula:C28H28FN7O2Colore e forma:SolidPeso molecolare:513.57ATR-IN-18
CAS:ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.Formula:C19H22F3N7O5SColore e forma:SolidPeso molecolare:517.48ATR-IN-5
CAS:ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Formula:C27H32F3N9OColore e forma:SolidPeso molecolare:555.6ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Formula:C29H31N5O4SColore e forma:SolidPeso molecolare:545.65ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formula:C23H27N7OPurezza:98%Colore e forma:SolidPeso molecolare:417.51ATR-IN-13
CAS:ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Formula:C24H24FN9OColore e forma:SolidPeso molecolare:473.51AZ 5704
CAS:AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan.Formula:C23H23FN6O2Purezza:99.69%Colore e forma:White SolidPeso molecolare:434.47ATR-IN-8
CAS:ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.Formula:C20H22N6O2SColore e forma:SolidPeso molecolare:410.49AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Formula:C24H28N4O3Purezza:98.1%Colore e forma:SolidPeso molecolare:420.5Camonsertib
CAS:Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Formula:C21H26N6O3Purezza:98.44% - 99.93%Colore e forma:Yellow SolidPeso molecolare:410.47Ref: TM-T62083
1mg160,00€1mL*10mM (DMSO)356,00€5mg394,00€10mg573,00€25mg893,00€50mg1.189,00€100mg1.639,00€200mg2.205,00€Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFormula:C23H21FN6O3Purezza:99.9%Colore e forma:White SolidPeso molecolare:448.45Ref: TM-T62684
1mg123,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg505,00€25mg982,00€50mg1.639,00€100mg2.538,00€ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Formula:C26H29FN6O3Colore e forma:SolidPeso molecolare:492.55ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Formula:C25H29FN6O3Colore e forma:SolidPeso molecolare:480.53ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Formula:C25H30N6O2Colore e forma:SolidPeso molecolare:446.54WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formula:C23H23F2N5O2Colore e forma:SolidPeso molecolare:439.46Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formula:C14H17N3O4Colore e forma:SolidPeso molecolare:291.302
