ATM/ATR
Gli inibitori di ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) prendono di mira chinasi chiave coinvolte nella risposta al danno al DNA (DDR) che vengono attivate in risposta a rotture del doppio filamento di DNA e stress da replicazione. Questi inibitori interrompono la capacità di queste chinasi di rilevare e riparare i danni al DNA, il che può portare a un aumento dell'instabilità genomica e alla morte cellulare, in particolare nelle cellule tumorali che dipendono da robusti meccanismi di riparazione del DNA per sopravvivere. Gli inibitori di ATM/ATR sono strumenti cruciali nella ricerca e nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una vasta gamma di inibitori di ATM/ATR di alta qualità per supportare la tua ricerca sulla risposta al danno al DNA, la biologia del cancro e lo sviluppo terapeutico.
Trovati 72 prodotti di "ATM/ATR"
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ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purezza:97.76%Colore e forma:SolidPeso molecolare:470.52azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Formula:C27H32FN5O2Purezza:97.41% - 99.72%Colore e forma:SolidPeso molecolare:477.57Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurezza:97.64% - 99.85%Colore e forma:SolidPeso molecolare:469.54Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormula:C20H21N7OPurezza:98.72% - 99.84%Colore e forma:SolidPeso molecolare:375.43PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purezza:97.72%Colore e forma:SolidPeso molecolare:389.88AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purezza:99.03% - 99.85%Colore e forma:SolidPeso molecolare:380.4CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Formula:C23H18Cl3FN4O3SPurezza:98% - 99.67%Colore e forma:SolidPeso molecolare:555.84Adefovir dipivoxil
CAS:Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFormula:C20H32N5O8PPurezza:98% - 99.80%Colore e forma:It Has Broad-Spectrum Antiviral ActivityPeso molecolare:501.47KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Formula:C30H33N3O5SPurezza:95.9% - 99.7%Colore e forma:SolidPeso molecolare:547.67AZ32
CAS:AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.Formula:C20H16N4OPurezza:98.68% - 99.68%Colore e forma:SolidPeso molecolare:328.37Mirin
CAS:Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.Formula:C10H8N2O2SPurezza:99.24%Colore e forma:SolidPeso molecolare:220.25ART0380
CAS:<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>Formula:C18H24N6O2SPurezza:99.06% - >99.99%Colore e forma:SolidPeso molecolare:388.49ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Formula:C27H24N4OColore e forma:SolidPeso molecolare:420.51Ceralasertib formate
CAS:Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.Formula:C21H26N6O4SColore e forma:SolidPeso molecolare:458.54ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Formula:C19H25N7OColore e forma:SolidPeso molecolare:367.45ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Formula:C19H22N8OColore e forma:SolidPeso molecolare:378.43Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Formula:C25H29F2N9O3Purezza:99.52%Colore e forma:SolidPeso molecolare:541.55ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purezza:98%Colore e forma:SolidPeso molecolare:458.56SKLB-197
CAS:SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.Formula:C25H24N6OColore e forma:SolidPeso molecolare:424.5(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Formula:C20H24N6O2SColore e forma:SolidPeso molecolare:412.51
