ATM/ATR
Gli inibitori di ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) prendono di mira chinasi chiave coinvolte nella risposta al danno al DNA (DDR) che vengono attivate in risposta a rotture del doppio filamento di DNA e stress da replicazione. Questi inibitori interrompono la capacità di queste chinasi di rilevare e riparare i danni al DNA, il che può portare a un aumento dell'instabilità genomica e alla morte cellulare, in particolare nelle cellule tumorali che dipendono da robusti meccanismi di riparazione del DNA per sopravvivere. Gli inibitori di ATM/ATR sono strumenti cruciali nella ricerca e nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una vasta gamma di inibitori di ATM/ATR di alta qualità per supportare la tua ricerca sulla risposta al danno al DNA, la biologia del cancro e lo sviluppo terapeutico.
Trovati 76 prodotti per "ATM/ATR".
Filtra per
Percentuale di purezza
0
100
|
0
|
50
|
90
|
95
|
100
- Prezzo più basso
- Prezzo più alto
- Purezza più bassa
- Purezza più alta
- Consegna più veloce
ATR-IN-14
CAS:ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.Formula:C20H20FN7OColore e forma:SolidPeso molecolare:393.42KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formula:C29H32N4O4S2Purezza:99.10% - 99.79%Colore e forma:SolidPeso molecolare:564.719ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Formula:C25H30N6O2Colore e forma:SolidPeso molecolare:446.54WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formula:C23H23F2N5O2Colore e forma:SolidPeso molecolare:439.46ATR-IN-32
CAS:ATR-IN-32 is an orally active ATR inhibitor that effectively suppresses the proliferation of MIA PaCa-2 cells. It significantly inhibits tumor growth in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 is applicable for studying cancers mediated by the ATR protein kinase, such as colorectal cancer and pancreatic cancer.Formula:C22H24N6O2Peso molecolare:404.47ATR-IN-17
CAS:ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).Formula:C22H28N6O2SColore e forma:SolidPeso molecolare:440.56ATR-IN-12
ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.Formula:C22H27N5O3SColore e forma:SolidPeso molecolare:441.55ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Formula:C25H29FN6O3Colore e forma:SolidPeso molecolare:480.53ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Formula:C26H29FN6O3Colore e forma:SolidPeso molecolare:492.55Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formula:C14H17N3O4Colore e forma:SolidPeso molecolare:291.302ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Formula:C26H31N7O3Colore e forma:SolidPeso molecolare:489.57ATR-IN-19
CAS:ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Formula:C18H19N7OSColore e forma:SolidPeso molecolare:381.45ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Formula:C27H36N6O3Purezza:98%Colore e forma:SolidPeso molecolare:492.61(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formula:C23H23F2N5O2Colore e forma:SolidPeso molecolare:439.458ATM-IN-13
CAS:ATM-IN-13 (A36) is an orally active selective ATM kinase inhibitor with a human IC50 of 0.3 nM. It disrupts the ATM-mediated DNA double-strand break repair signaling pathway, reduces phosphorylation levels of ATM and p53, and inhibits the ATM-dependent DNA damage response. ATM-IN-13 is applicable in colorectal cancer research.Formula:C27H33N5OPeso molecolare:443.58ATR kinase-IN-2
CAS:ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formula:C24H29F2N9O2Colore e forma:SolidPeso molecolare:513.54
