Altri inibitori

<p>Cinatrin C2, a phospholipase A2 (PLA2) inhibitor, has an IC50 value of 800 μM and can be extracted from the Circinotrichum falcatisporum strain RF-641.</p>

<p>Tonantzitlolone activates TRPC1/4/5 channels, PKCα/θ, inhibits IRS1/PI3K/AKT, and triggers HSF1 to induce glucose dependence.</p>

<p>NCATS-SM4487 is a highly selective inhibitor of GALK1 (IC50: 0.05 μM).</p>

<p>MV151 is a fluorescent proteasome inhibitor that targets all active subunits of the proteasome and immunoproteasome in living cells.</p>

<p>BLU2864: oral PRKACA inhibitor, IC50=0.3 nM, potential in cancer/poly. kidney disease research.</p>

<p>Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.</p>

<p>YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.</p>

<p>ELOVL1-IN-2 weakly inhibits ELOVL1 enzyme (IC50: 21 μM) and shows moderate potency in HEK293 cells (IC50: 6.7 μM).</p>

<p>Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins in human skeletal muscle cells.</p>

<p>OB-1 is a STOML3 inhibitor that interferes with the self-association of stomatin, inhibiting fat formation and blocking lipid droplet growth.</p>

<p>O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog.</p>

<p>PREP inhibitor-1 is a prolyl oligopeptidase (PREP) inhibitor for the study of Alzheimer's disease.</p>

<p>VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.</p>

<p>NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.</p>

<p>Skp2 inhibitor 1 is a Skp2-Cks1 interaction inhibitor (IC50: 2.8μM) with antitumor activity and can be used to study cancer.</p>

<p>ARN19702: orally active, brain-penetrant, selective NAAA inhibitor, IC50 230 nM, broad analgesic profile.</p>

<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>

<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>

<p>4',5'-Dibromofluorescein (Eosinic acid) is a fluorescent dye that can be used as a ligand for protein characterization by spectroscopic analysis.</p>

N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)

<p>TEM1/CD248 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.6 kDa and the accession number is Q91V98.</p>

<p>Norbiotinamine, a biotin alternative, is a sulfur-containing organic compound with a structure similar to that of biotin.</p>

<p>Haloxon is an organophosphorus anthelmintic. Haloxon is used against nematodes of the abomasum and small intestine in ruminants.</p>

<p>GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.</p>

<p>(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).</p>

<p>Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.</p>

<p>2-Selenouracil is a specialized photosensitizer for photodynamical therapy.</p>

<p>BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.</p>

<p>L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.</p>

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

<p>Metrizoic acid is an ionic contrast medium. Metrizoic acid displays high osmolality and has a risk of inducing allergic reactions.</p>

<p>CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.</p>

<p>TCblR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-58 KDa and the accession number is Q9NPF0.</p>

<p>(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, can adopt beta-bend and helical structures, thereby facilitating a preferred side-chain orientation within the peptide.</p>

<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>

<p>N-Octylmaleimide is an alkylmaleimide, which can inhibit rat liver glucose 6-phosphatase.</p>

<p>Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.</p>

<p>PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.</p>

<p>BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.</p>

<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>

<p>Benzylacyclouridine (BAU) is a specific UrdPase inhibitor, uridine metabolism and potentiate toxicity of 5-Fu against human prostate cancer cells antitumor.</p>

<p>Daphnin is one of the main coumarin bioactive ingredients with antibacterial activity. Daphnine is isolated from the entire Daphne fragrance, which is a folk medicine used in China to relieve fever.</p>

<p>sodium 4-pentynoate is a alkynylacetate analogue.</p>

<p>L-690330 inhibits human/bovine inositol monophosphatase; Ki: 0.19-0.42 μM. 10x potency vs. mouse/rat IMPase.</p>

<p>Demethyl 8-Epidiosbulbin E acetate is a structural analog of 8-Epidiosbulbin E acetate, a furan analog found in Dioscorea bulbifera L. 8-Epidiosbulbin E acetate is a furan analog found in Dioscorea bulbifera L. It is a structural analog of 8-Epidiosbulbin E acetate.</p>

<p>β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.</p>

<p>SPL-410 is a highly potent,selective and orally active inhibitor of hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a)(IC50 of 9 nM).</p>

<p>Endogenous fatty acid glycerol ester</p>

<p>Anisylacetone (Anisylacetone) is an effective lure for the male melon fly.</p>

<p>PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.</p>

<p>3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.</p>

<p>Dextromethorphan is a noncompetitive NMDA receptor antagonist and sigma-1 agonist that was approved by the FDA in 1958 for use as a cough suppressant.Cost-effective and quality-assured.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot</p>

<p>Isopulegol has antioxidant, and neuroactive properties. It also has gastroprotective effects induced by isopulegol appear to be mediated, at least in part, by endogenous prostaglandins, K+ATP channel opening and antioxidant proprieties related to GSH increased.</p>

<p>4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine maleate is a useful organic compound for research related to life sciences and the catalog number is T66094.</p>

<p>Phenylmalonic acid is a useful organic compound for research related to life sciences. The catalog number is T65896 and the CAS number is 2613-89-0.</p>

<p>Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65755 and the CAS number is 144689-93-0.</p>

<p>Usaramine N-oxide is a flavonoid isolated from Crotalaria pallida, and possesses anti-inflammatory activities.</p>

<p>IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.</p>

<p>N-(3-Fluorophenyl)piperidin-4-amine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67608 and the CAS number is 923565-91-7.</p>

<p>Trinexapac-ethyl is a useful organic compound for research related to life sciences. The catalog number is T65154 and the CAS number is 95266-40-3.</p>

<p>1,4-Bis(4-nitrophenyl)piperazine is a useful organic compound for research related to life sciences. The catalog number is T64560 and the CAS number is 16264-05-4.</p>

<p>2-Chloroisonicotinohydrazide is a useful organic compound for research related to life sciences. The catalog number is T66558 and the CAS number is 58481-04-2.</p>

<p>Aeide-C1-NHS ester, an alkyl/ether-based PROTAC linker, finds utility in the synthesis of PROTACs[1].</p>

<p>MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor used to study conditions linked to muscle wasting, encompassing both skeletal and cardiac muscle atrophy [1].</p>

<p>5-Chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione is a useful organic compound for research related to life sciences. The catalog number is T66943 and the CAS number is 73742-45-7.</p>

<p>(11aS)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine is a useful organic compound for research related to life sciences and the catalog number is T67271.</p>

<p>2-Oleoylglycerol is a lipid found in palm kernels that acts as a GPR119 agonist with neuroprotective properties and can be used in steatohepatitis modeling.</p>

<p>n-Undecyl-β-D-Thiomaltopyranoside is a useful organic compound for research related to life sciences. The catalog number is TF0048 and the CAS number is 148565-57-5.</p>

<p>Biotin-PEG4-alcohol is a useful organic compound for research related to life sciences and the catalog number is T64452.</p>

<p>SIAIS117: A Brigatinib-VHL-1 ALK PROTAC; degrades ALK G1202R, inhibits SR/H2228 cells, may fight small cell lung cancer.</p>

<p>2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67443 and the CAS number is 127337-60-4.</p>

<p>N4-Methylasparagine is a useful organic compound for research related to life sciences and the catalog number is T64610.</p>

<p>(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone is a useful organic compound for research related to life sciences. The catalog number is T67215 and the CAS number is 1103738-26-6.</p>

<p>n-Dodecyl-β-D-Thiomaltopyranoside is a useful organic compound for research related to life sciences. The catalog number is TF0058 and the CAS number is 148565-58-6.</p>

<p>(H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 trifluoroacetate is a useful organic compound for research related to life sciences and the catalog number is T64688.</p>

<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>

<p>Sodium cholate is a useful organic compound for research related to life sciences and the catalog number is T64511.</p>

<p>MDH1/2 inhibitor compound 16c is a useful organic compound for research related to life sciences and the catalog number is T64662.</p>

<p>Potassium cinnamate is a useful organic compound for research related to life sciences. The catalog number is T66338 and the CAS number is 16089-48-8.</p>

<p>(R)-5-Chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67331 and the CAS number is 721401-53-2.</p>

<p>Z-Arg-OH.HCl, an amino acid derivative, finds extensive application in life science research.</p>

<p>Citadiol hydrobromide is a useful organic compound for research related to life sciences. The catalog number is T67636 and the CAS number is 103146-26-5.</p>

<p>D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (PpyLuc), exhibiting an IC50 value of 0.1 μM. This analog of D-luciferin interacts non-specifically with the ATP and luciferin binding sites within the active site of PpyLuc.</p>

<p>Octyl 2-aminoacetate hydrochloride is a valuable organic compound for life sciences research (catalog number: T65113, CAS number: 39540-30-2).</p>

<p>(trans,trans)-4-Pentyl-4'-vinyl-1,1'-bi(cyclohexane) is a useful organic compound for research related to life sciences. The catalog number is T65465 and the CAS number is 129738-34-7.</p>

<p>4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.</p>

<p>DL-Glyceraldehyde-3-phosphate (3-Phosphoglyceraldehyde) inhibits acyltransferases and inhibits the growth of E. coli at high concentrations.</p>