Reagenti sintetici

<p>Applications Dimethyl Acetylenedicarboxylate is a biocide that is added to biodiesels to inhibit and remove microbial growth. It can rapidly penetrate the skin and cause aberrations in the activities of the glycogenic, lipogenic, and tricarboxylic acid metabollic pathways. It also causes delayed and pain-free dermal burns.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Poon, R., et al.: Arch. Toxicol., 85(11), 1419-1427 (2011); Klain, George J., et al.: Fund. Appl. Toxicol., 10(4), 730-5 (1988); Slovak, A. J. M., et al.: Contact Dermatitis, 11(1), 29-30 (1984)<br></p>

<p>Applications 3,5-Di-t-butyl-2-hydroxybenzaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-t-butyl-2-hydroxybenzaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).<br>References Tuerkkan, B. et al.: Trans. Met. Chem., 36, 679 (2011); Fusi, F. et al.: Biochem. Biopharmacol., 69, 485 (2005);<br></p>

<p>Applications An intermediate of synergistic pesticide Boscalid. Also, used in the preparation of thieno[2.3-b]pyrrole derivatives as cannabinoid receptor agonists useful in mono- and combination therapy of diseases.<br>References Granger, D., et al.: Arthritis Rheum., 37, 1053 (1994), Robinson, R., et al.: J. Med. Chem., 39, 10 (1996),<br></p>

<p>Applications TAE 684 is a potent, selective, and efficacious inhibitor of NPM-ALK, a fusion protein that is a key regulator of oncogenic events that drives the survival and proliferation of anaplastic large-cell lymphomas. Potent ALK inhibitor<br>References Schoenherr, C., et al.: Oncogene., 31, 5193 (2012); Tanizaki, J., et al.: Clin. Cancer. Res., 18, 6219 (2012); Heuckmann, J.M., et al.: Clin. Cancer. Res., 18, 4682 (2012);<br></p>

<p>Applications 4-Methoxybenzenemethanamine is used in the synthesis of COX2 inhibitors based on a pyrimidine scaffold. Also used in the preparation of SIRT1 inhibitors. Used in anti-cancer treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tietz, O. et al.: Org. Biomol. Chem., Eur. J. Med. Chem., 69, 125 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications Heptanoyl Chloride is used in the synthesis of novel class of 2-Aminopyrimidines as CDK1 and CDK2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Samanta, R., et al.: Org. Lett., 14, 5518 (2012); Sabbah, M., et al.: Bioorg. Med. Chem., 20, 4727 (2012);<br></p>

<p>Applications A potent competitive inhibitor of protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP.<br>References Hidaka, H., et al.: J. Biol. Chem., 260, 5, 2922 (1985),<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>

<p>Applications (1R,2R,3S,5R)-(-)-2,3-Pinanediol is a bicyclic monoterpene diols that has been shown to induce differentiation of S91 melanoma and PC12 pheochromocytoma cells and thus provide possible therapeutic and sunless tanning use. (1R,2R,3S,5R)-(-)-2,3-Pinanediol is a microbial oxidation product of (-)-β-pinene, a flavor and fragrance monoterpene.<br>References Farooq, A. et al.: Zeitsch. Naturforsch. C J. Biosci., 57, 686 (2002); Brown, D.A. et al.: Pigment Cell Res., 12, 36 (1999);<br></p>

<p>Applications (-)-DIBENZOYL-L-TARTARIC ACID MONOHYDRATE (cas# 62708-56-9) is a useful research chemical.<br></p>

<p>Applications N-(2,4-Dinitro-5-fluorophenyl)-L-valinamide is used in the synthesis of chiral variants of Marfey’s reagent. It is also used in the preparation of phaeofungin from Phaeosphaeria.<br>References Bhushan, R. et al.: Acta. Chrom., 20, 329 (2008); Singh, S. et al.: J. Nat. Prod., 76, 334 (2013);<br></p>

<p>Applications MNI-caged-L-glutamate, is a new caged neuroactive amino acid, that use 4-methoxy-7-nitroindolinyl- (MNI) group to make caged ligands specific for glutamate receptor sub-types. MNI-caged-L-glutamate, rapidly release glutamate when photolysed.<br>References Palma-Cerda, F., et al.: Neuropharmacology, 63, 624 (2012); Canepari, M. J. Neuroscience Methods, 112, 29 (2001);<br></p>

<p>Applications 2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.<br>References Barnett, H., et al.: Bioorg. Med. Chem. Lett., 19, 158 (2009); Tsukamoto, I., et al.: Bioog. Med. Chem., 16, 9524 (2008)<br></p>

<p>Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>

<p>Stability Hygroscopic<br>Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.<br>References Chan, C., et al.: Cell, 154, 556-568 (2013)<br></p>

<p>Applications Alpha-(trifluoromethyl)styrene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3,5-Dibromobenzaldehyde is a dibrominated benzaldehyde that is a very useful building block for the preparation of a wide range of biologically active compounds such as a antibacterials<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, S. et al.: Bioorg. Med, Chem., 12, 3017 (2004); Balderamos, M. et al.: Exp. Biol. Med., 233, 1395 (2008);<br></p>

<p>Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>

<p>Applications SKF 81297C is a dopamine D1 agonist (1).<br>References (1) Bergman, J., et. al.: J. Pharmacol. Exp. Ther., 273, 40 (1995)<br></p>

<p>Applications Sildenafil (S435000) derivative.<br></p>

<p>Applications 5-Methylisoxazole-3-carboxylic Acid is a metabolite of UTL-5b, a structural analog of the anti-arthritic drug, Leflunomide (L322750).<br>References Shaw, J. et al.: Eur. J. Drug. Metab. Ph., 37, 83 (2012)<br></p>

<p>Applications Lithium Chloride is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br>References Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>

<p>Applications Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.<br>References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);<br></p>

<p>Applications rac 2-Lauroyl-3-chloropropanediol-d5 (cas# 1330055-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.<br>References Wolfe, J., et al.: J. Am. Chem. Soc., 121, 9550 (1999);<br></p>

<p>Applications N-Boc-hydroxylamine is the protected form of Hydroxylamine (HCl: H943705). Hydroxylamine is used as an inhibitor between Z and P680 in photosystem II within plant chloroplasts. Hydroxylamine is also known to induce chromosomal damage in mammalian cells, inducing mutagenesis.<br>References Ghanotakis, D. &amp; Babcock, G.: FEBS Lett., 153, 231 (1983); Somers, C. &amp; Hsu, T.: P. Natl. Acad. Sci. USA, 48, 937 (1962)<br></p>

<p>Applications 4-Bromostyrene<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications Darodipine, is a calcium channel antagonist.<br>References Matucci, R., et al.: British J. Pharmacol., 122, 1353 (1997);<br></p>

<p>Applications Silver Acetate is used as a reagent in chemical synthesis in reaction such as carbonylation of primary and secondary amines as well as in woodward cis-hydroxylation converting alkenes into cis-diols. Also used in gum, lonzenges and sprays that are targeted to assist people in quitting the habit of smoking since it produces a bad taste when combined with cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, L., et al.: J. Phys. Chem., 59, 1060 (1955); Woodward, R., et al.: J. Am. Chem. Soc., 80, 209 (1958); Lancaster, T., et al.: Cochrane DB Syst. Rev., 2, 191 (2000);<br></p>

<p>Applications 1,3-Diiodopropane is a useful research chemical. A reagent used in the preparation of synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial properties.<br>References Ellis, G. L., et al.: Bioorg. Med. Chem. Lett., 18, 1720 (2008)<br></p>

<p>Applications 4-Chlorophenyl Isocyanate, is an intermediate used for the synthesis of novel pyrimido[5,4-c]quinolin-4(3H)-one derivatives, having antibacterial and antifungal activities. It is also shown to have anti tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Yu., et al.: Youji Huaxue, 33(5), 1074 (2013); Moos, G. E., et al.: Cancer Res., 31(7), 937 (1971);<br></p>

<p>Applications Ethyl Succinoyl Chloride, used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012);<br></p>

<p>Applications CUR 61414 is a proline derivative as mediator of hedgehog signaling pathways for pharmaceutical and cosmetic uses. CUR 61414 is a Nucleoside analog. CUR 61414 is an antimetabolite antitumor combination Gemcitabine cancer treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Van der Riet, P., et al.: Cancer Res., 54, 25 (1994), Hahn, H., et al.: Cell, 85, 841 (1996), Johnson, R., et al.: Science, 272, 1668 (1996), Ingham, P., et al.: Genes Dev., 15, 3059 (2001),<br></p>

<p>Applications Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.<br>References Ren, J. et al.: Eur. J. Med. Chem., 44, 4259 (2009)<br></p>

<p>Applications (R,R)-1,2-Cyclohexanedicarboxylic Acid (cas# 46022-05-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.<br>References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),<br></p>

<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>

<p>Applications GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor.<br></p>

<p>Applications Nickel(II) Bromide, is used as a source of bromide ion. It is also an important raw material used in various chemical synthesis and also as a catalyst in cross-coupling reactions.<br>References Pramanik, M. et al.: RSC Adv. 2015, 5 (53), 42762-42767.<br></p>

<p>Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.<br>References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)<br></p>

<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>

<p>Applications Inhibits the intestinal absorption of Phenylalanine, making it a prospective treatment for phenylketonuria.<br>References Shimomura, K., et al.: J. Biochem., 78, 269 (1975), Ambler, J., et al.: Bioorg. Med. Chem. Lett., 9, 737 (1999),<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications 3-Hydroxyquinoline is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetragedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002);<br></p>

<p>Stability Moisture Sensitive<br>Applications O-Acetylsalicyloyl chloride is used in the derivatisation of amines, and also improve electrochemical detection of these amines when they are run through high-performance liquid chromatography. O-Acetylsalicyloyl chloride is also used as a reagent to synthesize benzimidazole derivatives, compounds that inhibit leukotriene synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banoglu, E., et al.: Bioorg. Med. Chem., 20, 3728 (2012); Smith, R., et al.: J. Chromatogr. A, 455, 349 (1988)<br></p>

<p>Stability Moisture Sensitive<br>Applications Bromotripyrrolidinophosphonium Hexafluorophosphate is a peptide coupling reagent that has been used in the synthesis of rostate tumor specific peptide-peptoid hybrid prodrugs.<br>References Li, S., et. al.: Chem. Commun., 47, 12840 (2011); Lee, J., et. al.: Bioorg. Med. Chem. Lett., 25, 2849 (2015)<br></p>

<p>Applications 1-Chloro-3-iodopropane is used as reagent in the synthesis of several organic compounds including that of (-)-Terengganensine A which is a complex heptacyclic monoterpene indole alkaloid. Also used in the synthesis of A-366 which is a potent inhibitor of histone methyltransferase G9a.<br>References Piemontesi, C., et al.: Angew. Chem. Int. Edit., 55, 6556 (2016); Sweis, R., et al.: ACS Med. Chem. Lett., 5, 205 (2014);<br></p>

<p>Applications Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.<br>References Firestone, A., et al.: Nature, 484, 125 (2012)<br></p>

<p>Applications 1,1-Cyclopropanedicarboxylic Acid, is an inhibitor of 1-aminocyclopropane-1-carboxylic Acid oxidase in Lycopersicum esculentum (Tomato plant). It can also be used as a building block for the synthesis of a series of cyclopropanecarboxamides, having antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petritis, K., et al.: Phytochemical Analy., 14, 347 (2003); Liu, X. H., et al.: Euro. J. Med. , 44, 2782 (2009);<br></p>

<p>Applications Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Neuroresearch &amp; Neuroprotective Product.<br>References Yuksel, M. et al.: J. Pharmacol. Exp. Therap., 305, 298 (2003); Tamura, Y. et al.: Biochim. Biophys. Acta, 484, 417 (1977); Ohno, H. et al.: Thromb. Res., 24, 445 (1981);<br></p>

<p>Applications 2-amino-3-methylpentan-1-ol (cas# 24629-25-2) is a useful research chemical.<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).<br>References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);<br></p>

<p>Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.<br>References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)<br></p>

<p>Applications tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate, is a building block used foe the synthesis of novel nicotinic acetylcholine receptor ligands with cognition-enhancing properties. It can also be used in the synthesis of chiral β-amino sulfides and β-amino thiols.<br>References Elliiot, R. L., et al.: Bioorg. Med. Chem. Lett., 6, 2283 (1996); Abreo, M. A., et al.: J. Med. Chem., 39(4), 817 (1996);<br></p>

<p>Applications Tetra-n-butylammonium Iodide is used in the preparation of novel quaternary amines to serve as antibacterial agents in the rise of drug-resistant bacteria. Also used in phosphonium reversible inhibitors of cholinesterases.<br>References Ingalsbe, M. et al.: Bioorg. Med. Chem. Lett., 19, 4984 (2009); Basova, N. et al.: J. Evol. Biochem. Phys., 47, 420 (2011);<br></p>

<p>Applications CPhos, is used as a catalyst in the synthetic preparation of palladium-catalyzed Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides.<br>References Han, C., et al.: J. Am. Chem. Soc., 131, 7532 (2009)<br></p>

<p>Applications D-(-)-Diisopropyl Tartrate is a reagent for kinetic resolution of racemic allylic alcohols and α-furfuryl amides by enantioselective epoxidation.<br>References Lee, E., et al.: J. Org. Chem., 1994, 59 1444; Jung, M., et al.: J. Am. Chem. Soc., 115, 12208 (1993); Wang, Z., et al.: Tetrahedron, 49, 2641 (1993)<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications rac-Clopidogrel Hydrogen Sulfate is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.<br>References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010); Defreyn, G. et al.: Thromb. Haemo., 65, 186 (1991);<br></p>

<p>Applications BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor.<br>References Kleyman, G., et al.: Nat. Med., 8, 392 (2002); Wozniak, M.A., et al.: Antiviral Res., 99, 401 (2013);<br></p>

<p>Applications An indole derivative used in synthesis of matrix metalloprotease inhibitors.<br>References Somei, M., et al.: Nat. Prod. Rep., 22, 73 (2005),<br></p>