Reagenti sintetici

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.<br></p>

<p>Applications Precursor to Kifunensine.<br>References Kayakiri, H., et al.: Chem. Pharm. Bull., 39, 1378 (1991),<br></p>

<p>Applications (-)-O,O’-Di-p-toluoyl-L-tartaric Acid (cas# 32634-66-5) is a compound useful in organic synthesis.<br></p>

<p>Applications MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance<br>References Jinwal, U. K., et al.: Pharm. Nanotechnol., 2, 217, (2014); Koren, J., et al. : PLoS One, 7, 35566 (2012)<br></p>

<p>Stability Unstable in Solution, Air Sensitive<br>Applications 2-HYDROXYTHIOPHENOL (cas# 1121-24-0) is a useful research chemical.<br></p>

<p>Applications (+)-Dihydroquinidine (cas# 1435-55-8) is a useful research chemical.<br></p>

<p>Applications N-Carbobenzyloxy-D-serine-beta-lactone (cas# 98632-91-8) is a useful research chemical.<br></p>

<p>Applications 4-Bromostyrene<br></p>

<p>Applications 2-Bromo-3-methylthiophene is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chern, J., et al.: Bioorg. Med. Chem. Lett., 14, 2519 (2004); Tatsumi, R., et al.: J. Med. Chem., 48, 2678 (2005)<br></p>

<p>Applications N-Boc-hydroxylamine is the protected form of Hydroxylamine (HCl: H943705). Hydroxylamine is used as an inhibitor between Z and P680 in photosystem II within plant chloroplasts. Hydroxylamine is also known to induce chromosomal damage in mammalian cells, inducing mutagenesis.<br>References Ghanotakis, D. &amp; Babcock, G.: FEBS Lett., 153, 231 (1983); Somers, C. &amp; Hsu, T.: P. Natl. Acad. Sci. USA, 48, 937 (1962)<br></p>

<p>Applications The R enantiomer of binaphthol derivative as chiral quenching agent.<br>References Strambini, G., et al.: Biochemistry, 29, 196 (1990), Gabellieri, E., et al.: Eur. J. Biochem., 221, 77 (1994), Cioni, P., et al.: Biophys. J., 86, 1149 (2004), Veldhuis, G., et al.: J. Biol. Chem., 280, 35148 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Indium(III) chloride tetrahydrate (cas# 22519-64-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Applications Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disea<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>

<p>Applications Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Vitamin D3 (V676045) analog.<br>References Roy, A., et al.: Steroids, 60, 530 (1995);<br></p>

<p>Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.<br>References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);<br></p>

<p>Applications 4-benzylmorpholine-2-carbonitrile (cas# 126645-52-1) is a useful research chemical.<br></p>

<p>Applications Volasertib (BI 6727) is a highly potent Polo-like kinase (PLK) inhibitor.<br>References Rudolph, D., et al.: Clin. Cancer Res., 15, 3094 (2009); Grinshtein, N., et al.: 71, 1385 (2011)<br></p>

<p>Applications Trifluoromethanesulfonic Acid Magnesium Salt is a strong acid that is used as a catalyst for esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. D., et al.: Chemical Rev., 77, 69 (1977);<br></p>

<p>Applications BDP 37 is a AMPA modulator that may exhibit therapeutic properties for treating Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI) (1,2,3,4). It is also an ampakine drug that facilitates activation of glutamatergic AMPA receptors.<br>References (1) Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)(2) Marini, A., et al.: J. Biol. Chem., 273, 29394 (1998)(3) Balkowiec, A., et al.: J. Neurosci., 22, 10399 (2002) (4) Dicou, E., et al.: Brain Res., 970, 221 (2003)<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Applications LY 2874455 is a pan-FGFR inhibitor which remain the focus of research for use in lung and bladder cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gozgit, J. et al.: Mol. Cancer Ther., 11, 690 (2012); Zhao, G. et al.: Mol. Cancer Ther., 10, 2200 (2011);<br></p>

<p>Applications A useful intermediate in the synthesis of polypeptides.<br></p>

<p>Applications 2-Amino-4-methylphenylboronic acid, pinacol ester<br></p>

<p>Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);<br></p>

<p>Stability Volatile<br>Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)<br></p>

<p>Applications 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel (M264880), a Febantel (F227000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suzuki, T., et al.: J. Med. Chem., 42, 3001 (1999); Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>

<p>Applications Tetrapropylammonium bromide (cas# 1941-30-6) is a useful research chemical.<br></p>

<p>Applications ZJ 43 is a glutamate carboxypeptidase II (GCPII) and N-acetylaspartylglutamate (NAAG) inhibitor that reduces the deleterious effects of excessive extracellular glutamate.<br>References Feng, J. et al.: Brain Res., 1469, 144 (2012); Zuo, D. et al.: J. Biol. Chem., 287, 21773 (2012); Feng, J. et al.: Brain Res., 1395, 62 (2011)<br></p>

<p>Applications An amide analog of Eugenol, and is used therapeutically as an antispasmodic.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 14, 6502 (2006),<br></p>

<p>Applications 4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.<br>References Perez-Cruz, F. et al.: Bioorg Med. Chem. Lett., 22, 5569 (2012); Liu, H. et al.: J. Mol. Cata. A. Chem., 244, 68 (2006);<br></p>

<p>Applications Pentadecanoic acid is a saturated fatty acid. Pentadecanoic acid was utilized as a biomarker to examine for the intake of milk fat in relation to its metabolic risk factors. Pentadecanoic Acid that is also produced by certain plant species and acts as an toxic essential oil, which is known to exhibits potential anxiolytic, antinociceptive and antimicrobial properties.<br>References Smedman, A.EM., et al.: Am. J. Clin. Nutr., 69, 22 (1999); Radulovic, N.S., et al.: Food. Chem. Toxiol., 50, 2016 (2012);<br></p>

<p>Applications 2-Amino-5-methylphenyboronic acid, pinacol ester<br></p>

<p>Applications (S)-(−)-α,4-Dimethylbenzylamine was used in the study of heterogeneous Raney nickel and cobalt catalysts for racemization and dynamic kinetic resolution of amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parvulescu, A., et al.: Adv. Synth. Catal., 350, 113 (2008);<br></p>

<p>Applications Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131.<br>References Wolff, J. et al.: Pharmacol. Rec., 50, 89 (1998);<br></p>

<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>

<p>Applications 1,2-Diformylhydrazine as a bidentate ligand forms 1:1 metal to ligand complexes with transition metals Mn, Zn and Ni. It combines with iron (II) and iron(III) in alkaline conditions to a complex of an intense red-purple color making it a useful reagent in spectrophotometric analysis of iron(II) and iron(III). It was observed that mice were more likely to develop lung tumor when administered 1,2-Diformylhydrazine as a 2% solution.<br>References Nagabhushana, B., et al.: Anal. Bioanal. Chem., 373, 299 (2002); Bhargavi, G., et al.: P. Indian As-chem. Sci., 115, 23 (2003); Toth, B., Z. Krebsforsch. Klin. O., 92, 11 (1978);<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications 5-(Trifluoromethyl)picolinic Acid is an intermediate used in the synthesis of β-secretase (BACE) inhibitors.<br>References Tresadern, G., et al.: Bioorg. Med. Chem. Lett., 21, 7255 (2011); Watanabe, T., et al.: Bioorg. Med. Chem., 20, 5839 (2010);<br></p>

<p>Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.<br>References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)<br></p>

<p>Applications Sodium Perborate Tetrahydrate acts as a bleaching agent using oxygen causing less degradation to dyes and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murray, L. et al.: J. Am. Oil Chem. Soc., 45, 493 (1968);<br></p>

<p>Applications Gilteritinib is an AXL inhibitor in cancer.<br>References Myers, S., et al.: J. Med. Chem. (2015)<br></p>

<p>Applications Phenidone is a dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor.<br>References Pilar, G. et al.: J. Phycol., 52, 1085 (2016);<br></p>

<p>Applications GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor.<br></p>

<p>Stability Hygroscopic<br>Applications A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.<br>References Lau, O.D. et al.: Mol. Cell, 5, 589 (2000);<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Indium(III) trifluoromethanesulfonate is a catalyst that is used for hetero Diels-Alder reactions including intermolecular Diels-Alder reactions. It is also a catalyst for efficient acylation of alcohols, phenols and amines.<br>References Kamlesh, K.C., et al.: Synlett, 1999, 1743 (1999), Ali, T., et al.: Tetrahedron Lett., 40, 5621 (1999)<br></p>

<p>Stability Volatile<br>Applications 2-Furfurylamine is used in the synthesis of 2-Amino-N-(2-furylmethyl)propanamide, as a novel alanylglycine equivalent synthesized by bacilysin synthetase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mah, R., et al.: Appl. Microbiol., 15, 866 (1967), Faber, K., et al.: Pure Appl. Chem., 69, 1613 (1997), Marahiel, M., et al.: Chem. Biol. 4, 561 (1997),<br></p>

<p>Applications Fmoc-beta-alaninol<br></p>

<p>Applications (E)-2-Thiopheneacrylic Acid is used in the synthesis of anti-HIV HEPT analogs. Also used in the synthesis of benzimidazole and caffeine (C080100) analogs as inhibitors of monoamine oxidase B.<br>References Pontikis, R. et al.: J. Med. Chem., 40, 1845 (1997); van den Berg, D. et al.: Bioorg. Med. Chem., 15, 1692 (2007);<br></p>

<p>Applications Lanthanum(III) Trifluoromethanesulfonate is a catalyst that is used for the trans-esterification of Jatropha curcas L. oil with methanol and higher alcohols. Studies on rats and mice showed that Lanthanum(III) Trifluoromethanesulfonate is a moderately hazardous substance causing slight irritation of the skin and that the maximum permitted concentration in the workplace is 2.0 mg/m3.<br>References Daniel, L., et al.: J. Am. Oil Chem. Soc., 91, 325 (2014); Zhurba, O.M., et al.: Toksikologicheskii Vestnik, no vol., 20 (2005)<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications CUR 61414 is a proline derivative as mediator of hedgehog signaling pathways for pharmaceutical and cosmetic uses. CUR 61414 is a Nucleoside analog. CUR 61414 is an antimetabolite antitumor combination Gemcitabine cancer treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Van der Riet, P., et al.: Cancer Res., 54, 25 (1994), Hahn, H., et al.: Cell, 85, 841 (1996), Johnson, R., et al.: Science, 272, 1668 (1996), Ingham, P., et al.: Genes Dev., 15, 3059 (2001),<br></p>

<p>Applications Ethyl Succinoyl Chloride, used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012);<br></p>