Reagenti sintetici

<p>Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist.<br>References Vassilev, L.T., et. al.: Sci., 303, 844 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakulsombat, M. et al.: Isr. J. Chem., 53, 127 (2013);<br></p>

<p>Applications 1-​Bromononane is a useful synthetic intermediate. It is used in the synthesis of cyclooxygenase-2 (COX-2), a new class of selective COX-2 inactivators. It is also used to prepare alkylimidazoles by N-alkylation of imidazoles as antibacterial agents.<br>References Kalgutkar, A., et al.: J. Med. Chem., 41, 4800 (1998); Khabnadideh, S., et al.: Bioorg. Med. Chem. Lett., 13, 2863 (2003)<br></p>

<p>Stability Unstable in Solution, Moisture Sensitive, Hygroscopic<br>Applications (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide is a building block used in stereoselective preparation of phosphinic acid phosphapeptide analogs of glutamyl-γ-glutamate as potent inhibitors of folylpolyglutamate synthetase. Also used in the synthesis of isoindoline carbamate and acylsulfonamide containing macrocyclic peptidomimetics as inhibitors of HCV NS3/4A protease.<br>References Bartley, D., et al.: J. Org. Chem., 70, 6757 (2005); Jiang, Y., et al.: J. Med. Chem., 57, 1753 (2014);<br></p>

<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Applications (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester is a dioxolane derivative used in the preparation of matrix metalloproteinases (MMP) inhibitors.<br>References Wada, C.K. et al.: J. Med. Chem., 45, 219 (2002); Chang, S.-J. et al.: Org. Proc. Res. Dev., 6, 329 (2002);<br></p>

<p>Applications Used in the preparation of sulfur aroma compounds.<br></p>

<p>Applications Erdafitinib is a fibroblast growth factor receptor inhibitor.<br>References Perera, T. P. S., et al.: Mol. Cancer Ther. 6, 1010 (2017);<br></p>

<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>

<p>Stability Volatile<br>Applications 2-Furfurylamine is used in the synthesis of 2-Amino-N-(2-furylmethyl)propanamide, as a novel alanylglycine equivalent synthesized by bacilysin synthetase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mah, R., et al.: Appl. Microbiol., 15, 866 (1967), Faber, K., et al.: Pure Appl. Chem., 69, 1613 (1997), Marahiel, M., et al.: Chem. Biol. 4, 561 (1997),<br></p>

<p>Stability Moisture Sensitive<br>Applications Benzeneacetyl Chloride is used in the synthesis of aromatic inhibitors of HIV-1 integrase. Also used in the preparation of napthalenic ligands with high affinity for melatonin receptor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burke, T. et al.: J. Med. Chem., 38, 4171 (1995); Yous, S. et al.: J. Med. Chem., 35, 1484 (1992);<br></p>

<p>Stability Photosensitive<br>Applications It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).<br></p>

<p>Applications Tetramethylammonium Hydroxide is used to prepare a new family of silicate/aluminosilicate mesoporous molecular sieves.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beck, J., et al.: J. Am. Chem. Soc., 114, 10834 (1992).<br></p>

<p>Applications A peripheral µ-opioid receptor antagonist. Gastroprokinetic.<br>References Zimmerman, D.M., et al.: J. Med. Chem., 37, 2262 (1994), Liu, S.S., et al.: Clin. Pharmacol. Ther., 68, 66 (2000), Taguchi, A., et al.: N. Engl. J. Med., 345, 935 (2001),<br></p>

<p>Applications GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.<br>References Jeffrey J.W., et al.: Clinical. Cancer. Rsch., 10, 1078 (2012); Murray, J.M., et al.: J. Medn. Chem., 55, 7686 (2012);<br></p>

<p>Stability Air Sensitive<br>Applications A multifunctional compound which shows antioxidant activity in a skin cell model of UVA-induced stress.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sies, H., et al.: Eur. J. Biochem., 215, 213 (1993), Meotti, F., et al.: Environ. Res., 94, 276 (2004),<br></p>

<p>Applications Sodium diformamide, 98% (cas# 18197-26-7) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications 1,5-Hexadien-3-ol is a reactant used in the synthesis of laurencia metabolite obtusenye.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Crimmins, M.T., et al.: J. Am. Chem. Soc., 125, 7592-7595 (2003)<br></p>

<p>Applications Platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane Complex Solution is a catalyst in the preparation of phenol functional silanes which are used as adhesion promoters.<br>References Amako, M., et al.: From Eur. Pat. Appl. (2000), EP 1041076 A2 20001004<br></p>

<p>Applications N-Carbobenzoxy-1,4-diaminobutane HCl is used in the synthetic preparation of pyrazolyl glucopyranoside and galactopyranoside derivative inhibitors of human sodium-glucose cotransporter 1 (SGLT1) for preventives or therapeutics for diseases related to hyperglycemia or galactosemia.<br>References Teranishi, H.; et al.: PCT Int. Appl. 215 pp. Patent 2004 CODEN:PIXXD2<br></p>

<p>Applications 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel (M264880), a Febantel (F227000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suzuki, T., et al.: J. Med. Chem., 42, 3001 (1999); Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>

<p>Applications (2-Bromoethyl)trimethylammonium Bromide (cas# 2758-06-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Paetzel, M., et al.: J. Biol. Chem., 272, 9994 (1997), Francavilla, C., et al.: Bioorg. Med. Chem. Lett., 19, 2731 (2009),<br></p>

<p>Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.<br>References Mizuno, S. et al.: Am. J. Respir. Cell. Mol. Biol., 47, 679 (2012)); Yoshizawa, Y. et al.: Mol. Pharm., 9, 3486 (2012);<br></p>

<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>

<p>Applications Main metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Harvilchuck, J., et al.: Toxicol. Lett., 183, 28 (2008), Harvilchuck, J., et al.: Toxicol., 264, 171 (2009), Woo, J., et al.: App. Microbiol., Biotechnol., 82, 873 (2009),<br></p>

<p>Applications Bismuth Subnitrate is a compound used in the synthesis of anti-inflammatory and anti-microbial pharmaceuticals for use in mammals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parker, K.. et al.: J. Dairy, Sci., 91, 169 (2008); Lougheed, K. et al.: Tuberculo., 89, 364 (2009);<br></p>

<p>Applications Thromboxane A2-receptor antagonist. Antiasthmatic.<br>References Hussein, Z., et al.: Clin. Pharmacol. Ther., 55, 441 (1994),<br></p>

<p>Applications A 5-HT3 receptor antagonist and used as an antiemetic (1,2).<br>References (1) Sato, N., et al.: Japan J. Pharmacol., 59, 443 (1992) (2) Haga, K., et al.: Japan J. Pharmacol., 63, 377 (1993)<br></p>

<p>Applications (4-Dimethylaminophenyl)di-tert-butylphosphine (cas# 932710-63-9) is a useful research chemical.<br></p>

<p>Applications 3,4-Difluoro-benzoic Acid is a useful synthetic intermediate. It is used to synthesize 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.<br>References Lim, C., et al.: Bioorgan. Med. Chem. Lett., 21, 2309 (2011);<br></p>

<p>Applications A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.<br>References Timmermans, A.D., et. al.: Am. J. Phys., 306, H1619 (2014)<br></p>

<p>Applications Cesium Acetate (cas# 3396-11-0) is a useful research chemical.<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.<br>References Emuebie, O. et al: Aus. J. Basic App. Sci., 5, 507 (2011); Cambal, L. et al.: Chem. Res. Toxicol., 24, 1104 (2011); Lam, X. et al.: J. Pharm. Sci., 86, 1250 (1997);<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic, Unstable in Solution<br>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (cas# 55738-75-5) is a compound useful in organic synthesis.<br>References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001)<br></p>

<p>Applications Protected Propargyl. A possible genotoxic compound that can affect the bacterial and mammalian cell systems.<br>References Glowienke, S. et al., Mutat. Res. Genet. Tox., 581, 23 (2005)<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.<br>References Wippich, Frank., et al.: Cell., 152, 791(2013); Corona, John A., et al.: Org. Process Res. Dev., 14, 712 (2010)<br></p>

<p>Applications K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.<br>References Sanvitale, C.E., et al.: PLoS One, 8, e62721 (2013)<br></p>

<p>Applications Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.<br>References Rosen, L., et al.: J. Clin. Oncol., 25, 2369 (2007), Sherman, S., et al.: New Engl. J. Med., 359, 31 (2008),<br></p>

<p>Stability Moisture Sensitive<br>Applications Potassium Disulfate is used in the synthesis of novel composite superionic conductors. Also used in the catalytic conversion of diethyl tartrate into pyruvate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bukun, N. et al.: Solid State Ionics, 136, 279 (2000); Sugiyama, S. et al.: Bull. Chem. Soc., 65, 2083 (1992);<br></p>

<p>Applications 4-Bromophenylhydrazine Hydrochloride is a reactant in the synthesis of fluoro substituted novel pyrazolylpyrazolines scaffold with antibacterial activity, antituberculosis activity against Mycobacterium tuberculosis H37Rv and antimalarial activity against Plasmodium falciparum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Karad, S.C., et. al.: Eur. J. Med. Chem., 84, 51 (2014)<br></p>

<p>Applications Synthetic pentasaccharide corresponding to the anti-thrombin binding site of heparin. Anti-thrombotic.<br>References Herbert, J.M., et al.: Cardiovasc. Drug Rev., 15, 1 (1997), Turpie, A.G.G., et al.: Expert Opin. Drug Saf., 4, 707 (2005),<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications Tetrabutylammonium Hydroxide is used in biological studies for the detection of counter-anion effect on antimicrobial activity of tetrabutylammonium salts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ingalsbe, M.L., et al.: Bioorg. Med. Chem., 19, 4984 (2009)<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications (R)-Ethyl 4-chloro-3-hydroxybutanoate is used in biological studies for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains.<br>References Liu, Y., et al.: Biotech. Lett., 27, 119 (2005);<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications Non-selective MAO-A/B inhibitor.<br>References Stout, S.C., et al.: J. Pharmacol. Exp. Ther., 300, 1085 (2002),<br></p>

<p>Applications Lithium Trifluoromethylsulfonate has been shown to improve the cycling performance of lithium-oxygen batteries.<br>References Nasybulin, E., et. al.: J. Phys. Chem. C, 117, 2635 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications 9-Mesityl-10-methylacridinium Tetrafluoroborate can be used for the synthesis of γ-butyrolactones, γ-lactams and pyrrolidines. 9-Mesityl-10-methylacridinium Tetrafluoroborate has been reported by Nicewicz et al. to mediate myriad transformations through Photoredox Catalysis. The applications include the anti-Markovnikov hydroamination of alkenes and addition of carboxylic acids to alkenes and the hydrotrifluoromethylation of styrenes using the Langlois reagent S673690.<br>References Gesmundo, N. J. et al.: Org. Lett. 17, 1316 (2015); Zeller, M. A., et al.: Org. Lett. 16, 4810 (2014); Nicewicz et al., J. Am. Chem. Soc., 135 (26), 9588–9591(2013)<br></p>

<p>Applications AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.<br>References Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007), Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2009),<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Morpholinylsulfur Trifluoride is a chemical reagent used in the preparation of proline analogs. Also used in the preparation of difluoropiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mykhailiuk, P. et al.: Tetrahedron 67, 3091 (2011); Surmont, R. et al.: Synlett., 12, 1933 (2009);<br></p>

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 2,4,5-Trifluorobenzaldehyde is a reactant in the enantioselective synthesis of (R)-selegiline, an anti-Parkinson's drug, (S)-benzphetamine, an anti-obesity agent, and (S)-sitagliptin, an anti-diabetic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dey, S., Sudalai, A.: Tetrahedron-Asymmetr., 26, 67 (2015)<br></p>