Standard farmaceutici

Applications Fluorescent Brightener KSN (cas# 5242-49-9) is a useful research chemical.

Applications 1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.
References Mao, Y., et al.: Synthesis, 47, 3133 (2015); Chen, H., et al.: Zhongguo Yiyao Gongye Zazhi, 44, 1086 (2013); Yin, X. J., et al.: Molecules, 4261 (2010)

Applications Used in the preparation of Epostane (E588850).

Applications 2',3'-Di-O-(tert-butyldimethylsilyl)-2'-deoxycytidine is an intermediate for biosynthesis of cholyl-CoA and oligodeoxyribonucleotides.
References Takamura-Enya, T. et al.: Chem. Res. Toxicol., 18, 1715 (2005); Wada, T. et al.: J. Am. Chem. Soc., 119, 12710 (1997)

Applications 2',5'-Difluoroacetophenone is used in the synthesis of pyrazole compounds as inhibitors of dipeptidyl peptidases. These compounds have been shown to produce anti-hyperglycemic effects.
References Hsu, T. et al.: J. Chin. Chem. Soc., 56, 1048 (2009);

Applications 2,6-Dimethyl-3,5-dicarboxy-4-(2-nitrophenyl)-1,4-dihydropyridine is used as a reactant in the preparation of hydroxyindolecarboxylate and hydroxycarbolinecarboxylate from nifedipine analogous cyanoethyl ester.
References Gorlitzer, K., et al.: Pharmazie, 55, 35 (2000)

Applications 2-Formylcinnamic Acid (cas# 28873-89-4) is a compound useful in organic synthesis.

Applications 2,6-Anhydro-5-deoxy-D-lyxo-hex-5-enonic Acid Methyl Ester 3,4-Diacetate is used as a reagent in the synthesis of the nucleoside antibiotic Herbicidin B. It is also a useful synthetic intermediate in the synthesis of Mirtazapine N-Glucuronide (M365015).
References Ichikawa, S., et al.: J. Am. Chem. Soc., 121, 10270 (1999)

Applications Glucocorticoid.

Applications A novel metabolite of Phenazopyridine (P313751).
References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),

Applications Controlled substance.

Applications N1,O2'-Dimethyladenosine Monohydriodide-d3, is the labeled a analogue of N1,O2'-Dimethyladenosine Monohydriodide (D447411), is an intermediate useful in the synthesis of N6,O2'-Dimethyladenosine (D447415), which is naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Applications Testosterone Hexanoate-d11 is the isotopic analog of Testosterone Hexanoate. Testosterone Hexanoate is a metabolite of testosterone(T155000), which is used in analytical studies to determine the use of anabolic steroid esters and related compounds in equine hair sample though ultra high performance liquid chromatography-tandem mass spectrometry.
References Gray, B.P., et al.: Analtica Chemica Acta, 787, 163 (2013); McKinney, A., et al.: Bioanalysis 1, 785 (2009)

Applications N,N-Dipropyl-2-(2-methyl-3-nitrophenyl)ethylamine is an intermediate used to prepare 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone and related compounds as a prejunctional dopamine receptor agonist.
References Gallagher, G., et al.: J. Med. Chem., 28, 1533 (1985); DeMarinis, R., et al.: J. Med. Chem., 29, 939 (1986)

Applications 4-Aminobenzoic-​2,​3,​5,​6-​d4 Acid Methyl Ester is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.
References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra-2-naphthalenyl-1,3-dioxolane-4,5-dimethanol, is a privileged ligand analogue of TADDOLs. It can be broadly used in asymmetric synthesis. It is also shown that the titanium TADDOLate catalysts have broad application towards carbonyl addition and cycloaddition.
References Seebach, D., et al.: Ange. Chem. Inter. Ed., 40, 92, (20010;

Applications 5,6,7-trimethyl-2,8-dihydro-1,8-naphthyridin-2-imine (cas# 69587-84-4) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-Carbomethoxy-4-hydroxy-α-bromoacetophenone, can be used for the synthesis of carboxyarylindoles and benzofurans as nonsteroidal antiinflammatory agents.
References Effland, R. C., J. of Med. Chem., 20, 1703 (1977);

Applications 5-Aminomethyl-salicylic Acid Methyl Ester Hydrochloride (cas# 90610-24-5) is a useful research chemical.

Applications 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-oxazole (cas# 39867-96-4) is a useful research chemical.

Applications 2-Aminopyrazine-5-carboxylic Acid Methyl Ester (cas# 13924-94-2) is a compound useful in organic synthesis.

Applications 1-(4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)phenyl)ethanone is used for the synthesis of bexarotene.
References Bhirud, S.B., et al.: PCT Int. Appl. 37pp. Patent 2011 CODEN:PIXXD2

Applications (S)-(-)-Malic-2,3,3-d3 Acid (CAS# 59652-74-3) is a useful isotopically labeled research compound.

Applications 1,2,3,4-Tetrahydro-1,2,5-naphthalenetriol is a a reagent used in pharmaceutical synthesis.

Applications 1-Naphthamide (cas# 2243-81-4) is a useful research chemical.

Applications Labelled 1-Naphthol (N367990). Used in the manufacturing of dyes, intermediates, synthetic perfumes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-(Methoxy-d3)-α-methyl-(αS)-benzeneethanamine Hydrochloride is the labelled form of 4-Methoxyamphetamine Hydrochloride (M261015), which is the HCl salt of 4-Methoxyamphetamine. 4-Methoxyamphetamine is a designer drug belonging to the amphetamine class and releases 5-hydroxytryptamine in brain tissue.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Menon, M., et al.: J. Pharmacol. Exp. Ther., 197, 272 (1976);

Applications 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione (cas# 31267-07-9) is a useful research chemical.

Applications Used in the synthesis of phenacetin metabolites.
References Focella, A. et al.: Can. J. Chem. 50, 2025 (1972)

Applications Ethyl Cyano(2-nitrophenyl)acetate (cas# 65548-02-9) is a compound useful in organic synthesis.

Applications N4-ACETYLCYTOSINE (cas# 14631-20-0) is a useful research chemical.

Applications L-Aspartic Acid (13c4, 99%; 15n, 99%) (cas# 202468-27-7) is a useful research chemical.

Applications 2-(Chloromethoxy)acetic Acid Ethyl Ester is used in the preparation of antiviral acyclonucleosides and their metabolites.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kutsuma, T. et al.: Heterocycles, 65, 1967 (2005); Hu, L. et al.: Guiy. Yix. Xueb., 33, 546 (2008);

Applications Hydrocinnamic-d5 Acid (phenyl-d5) (CAS# 35845-62-6) is a useful isotopically labeled research compound.

Applications 3-Fluoro-4-hydroxycinnamic Acid (cas# 56926-74-0) was used in an study involving the enyzmatic decarboxylation of bio-based phenolic acids.
References Schweiger, A. K., et al.: ACS Sustain. Chem. Eng., 7, 16364 (2019)

Applications 4-Bromotoluene-d3 is isotopically labelled form of 4-Bromotoluene (B688235), which is used as a reagent in the preparation of aromatic diselenides that are useful for generating anticancer lead compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rizvi, M.A., et al.: Bioorg. Med. Chem. Lett., 24, 3440 (2014); Leung, C., et al.: Angew Chem., Int. Ed., 52, 766 (2013);

Applications (S)-(-)-Ofloxacin-d3 (N-methyl-d3) (CAS# 2208780-63-4) is a useful isotopically labeled research compound.

Applications (±)-Carvedilol-d4 (ethyl-d4) (CAS# 1133705-56-2) is a useful isotopically labeled research compound.

Applications Testosterone-2,2,4,6,6-d5 Propionate is a useful isotopically labeled compound of Testosterone Propionate (T155045)

Applications Labelled Dapoxetine (D185700). Selective serotonin reuptake inhibitor (SSRI).
References Feret, B., et al.: Formulary, 40, 227 (2005),

Applications rac-cis-N-Desmethyl Sertraline-d3 hydrochloride is a labelled metabolite of rac-cis-N-Desmethyl sertraline hydrochloride (D292100). N-Desmethyl sertraline is significantly less active analogue as compared to the methylated compound, sertraline.
References Welch, W.M., et al.: J. Med. Chem. 27, 1508 (1984)

Applications (±)-Zopiclone-d3 (N-methyl-d3) (CAS# 1398066-10-8) is a useful isotopically labeled research compound.

Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.
References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);

Applications Methylamine-d5 DCl (CAS# 14779-55-6) is a useful isotopically labeled research compound.
Chemical Name: Methylamine-d5 DCl (CAS# 14779-55-6) is a useful isotopically labeled research compound.

Applications Androstenedione (A637550) analog, an aromatase inhibitor.
References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),

Applications (±)-Betaxolol-d7 HCl (iso-propyl-d7) (CAS# 1219802-92-2) is a useful isotopically labeled research compound.

Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)

Applications Nitroethane-2,2,2-d3 (CAS# 1219802-04-6) is a useful isotopically labeled research compound.

1,3,5-Naphthalene trisulfonic acid is an organic compound that is the product of the sulfonation of naphthalene. It has been shown to inhibit the activity of 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, enzymes involved in steroidogenesis. The maximal response was observed at a concentration of 500 μM with a detection time of 30 minutes. Xenopus oocytes were used for expression and chloride currents were recorded as an indicator for enzyme activity. Concentration-response curves were generated with organic solvents such as methanol and dimethyl sulfoxide (DMSO). 1,3,5-Naphthalene trisulfonic acid also inhibits the oxidative activities of some enzymes such as lipoxygenase and cyclooxygenase.

3-Dehydro retinol is a carotenoid that is found in the skin. It is derived from retinol, and has been shown to have antioxidant properties. 3-Dehydro retinol can be isolated from the fungus Monascus purpureus by chromatographic methods. The enzyme activities of 3-dehydroretinol are not well understood, but it has been hypothesized that chronic exposure to this compound may lead to an increase in cell proliferation or an increase in cell differentiation. 3-Dehydro retinol has also been shown to inhibit the oxidation of other molecules such as hydrogen chloride.