Nucleotidi

N-Pyrrolo-2'-deoxycytidine is a nucleoside analog that is used in the laboratory as a template for DNA synthesis. It has been shown to be an effective inhibitor of human pathogens. N-Pyrrolo-2'-deoxycytidine binds to DNA and prevents replication by interfering with the binding of the enzyme polymerase to the template strand, which leads to denaturation of the complementary strand and blocking of DNA elongation. This drug has been shown to bind specifically to sequences that are unpaired in duplexes, such as single-stranded telomeres. N-Pyrrolo-2'-deoxycytidine can also be used as a fluorescence probe for detecting dsDNA duplexes.

2',3'-Dideoxy-5'-O-DMT-uridine is a nucleoside for use in research applications

7-Cyano-7-deaza-2'-deoxyadenosine is a nucleoside analog that inhibits the growth of virus by competing with deoxyadenosine for incorporation into DNA and RNA. 7-Cyano-7-deaza-2'-deoxyadenosine also stabilizes dna duplexes and prevents them from breaking down. It has been shown to be effective against herpes simplex virus, which causes painful blisters on the skin or genitals. This drug has been used in clinical trials as an antiviral agent. 7-Cyano-7-deaza-2'-deoxyadenosine is synthesized from 2',3'-didehydrocytidine under the following conditions:

Uridine-5-oxyacetic acid is a molecule that is synthesized from uridine and 5-oxo-4-pyrone. It is an intermediate in the synthesis of pyrimidine nucleotides, which are important for DNA replication, repair, and transcription. Uridine-5-oxyacetic acid has been shown to form stable complexes with subtilisin. These complexes have been determined by X-ray crystallography to be glycosidic bond between the uridine and the enzyme. The enzymatic activity of subtilisin can be inhibited by these complexes, which may lead to frameshifting during bacterial translation. This inhibition leads to a less efficient protein synthesis process and a decrease in the production of gene products.

3'-Deoxyuridine is a synthetic antibiotic that is used in the treatment of viral infections, such as hepatitis B and C, and HIV. 3'-Deoxyuridine competitively inhibits the synthesis of RNA by binding to the enzyme RNA polymerase. This drug also has antiviral activity against the human cytomegalovirus (CMV) and Hepatitis C virus (HCV). 3'-Deoxyuridine is synthesized from uracil in an organic solvent, trifluoroacetic acid, at low temperatures. The incorporation of deoxynucleoside triphosphates into DNA occurs after cleavage of the terminal phosphate group by water vapor.

Thymidylyl-3'-5'-thymidine ammonium is a cytotoxic drug that belongs to the class of thymidylate synthase inhibitors. It inhibits enzymes responsible for DNA synthesis and repair by binding to the active site of these enzymes and forming covalent bonds with amino acid residues. Thymidylyl-3'-5'-thymidine ammonium can be used as a therapeutic agent in radiation therapy because it is more effective than other drugs at inhibiting cell growth. Thymidylyl-3'-5'-thymidine ammonium has been shown to inhibit the activity of carcinogenic compounds, such as benzo[a]pyrene and benzene, in a model system. Thymidylyl-3'-5'-thymidine ammonium also has the ability to form covalent bonds with dna duplexes and change their conformational properties.

N2-DMF-5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has antiviral, anticancer and immunomodulating properties. It is synthesized from 2′,3′-dideoxyadenosine 5′-monophosphate by the condensation of 2,6-dimethylaniline with methylguanosine 5′-monophosphate and 5,6-dimethylaniline. The modification of the guanine base in N2-DMF-5'-O-DMT-2'-O-methylguanosine to an O6 -methyl group results in increased affinity for the ribonucleotide reductase enzyme (RNR) and inhibition of DNA synthesis.

2'-Deoxycytidine is a deoxyribonucleotide that is used in the synthesis of DNA. It has been shown to have potent antitumor activity against solid tumours and may be useful for the treatment of leukemic mice. This compound has been shown to inhibit the kinase activity of IL-2 receptor and Toll-like receptor, which are proteins that regulate the immune response. 2'-Deoxycytidine also inhibits DNA polymerase activity and thermal expansion, which may make it a good candidate as an anticancer drug.

Thymidine is a nucleoside that is found in cells and is involved in the synthesis of DNA. Thymidine has been shown to inhibit the growth of tumor cells through apoptosis. In addition, thymidine can be used for the treatment of bowel disease by reducing inflammation and increasing the production of mucin. The mechanism by which thymidine exerts its effects on tumor cells is not well understood, but it may involve interactions with dna binding activity and enzyme activities.