Flavonoidi e Polifenoli

<p>Applications Chlorophyllin Copper Trisodium Salt, is a water soluble derivative of Chlorophyll (C379880), which has shown to have has been shown to have both anticarcinogenic and antigenotoxic properties.<br>References Grossi, M., et al.: Toxicology Lett., et al.: 214, 235 (2012); Prasad, K., et al.: Curr. Res. Chem., 3, 98 (2011);<br></p>

<p>Impurity Diosmin EP Impurity A<br>Applications Isoacetovanillone (Diosmin EP Impurity A) is a volatile compound isolated from oak wood. Also a byproduct in the production of Acetovanillone.<br>References Smith, C., et al.: Toxicol. Sci., 69, 265 (2002), Sun, L., et al.: Anticancer Res., 24, 179 (2004), Fernandez de Simon, B., et al.: J. Agric. Food Chem., 57, 3217 (2009),<br></p>

<p>Applications 7-Hydroxy Coumarin-d5 is the labeled analogue of 7-Hydroxy Coumarin (H924875), a metabolite of Coumarin that is present in many plants and is the aglucon of skimmin.<br>References Schilling, et al.: Nature, 221, 664 (1969); Indahl, S., et al.: Xenobiotica, 1, 13 (1971); Thompson, S.G., et al.: Antimicrob. Agents Chemother., 18, 264 (1980)<br></p>

<p>Applications The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ryu, M.J. et al.: Biochem. Biophys. Res. Comm., 377, 1304 (2008); Sandur, S.K. et al.: Carcinogenesis, 28, 1765 (2007); Huang, T. et al.: J. Agric. Food. Chem., 58, 10639 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.<br>References Ingolfsson, H., et al.: FEBS Lett., 585, 3101 (2011),<br></p>

<p>Applications Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative.<br>References Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013);<br></p>

<p>Applications Silybin B is the 2R, 3R, 7‘S, 8‘S isomer of Silybin (S465850); a natural occurring flavolignan that exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells.<br>References Lee, D.Y.W, et al.: J. Nat. Prod., 66, 1171 (2003); Trappoliere, M., et al.: J. Hepatol., 50, 1102 (2009); Borsari, M., et al.: J. Inorg. Biochem., 85, 123 (2001)<br></p>

<p>Applications Triclosan O-β-D-Glucuronide is a metabolite of the bacteriostat, Triclosan (T774250).<br>References Moss, T. et al.: Food Chem. Toxicol., 38, 361 (2000); Wu, J. et al.: Sepu, 27, 724 (2009);<br></p>

<p>Applications An antioxidant flavenoid.<br>References Dixon, D., et al.: J. Biol. Chem., 285, 36322 (2010), Sheu, M., et al.: Chem. Pharm. Bull., 58, 1187 (2010),<br></p>

<p>Applications Methyleugenol is a phenylpropene that is commonly found in plants such as nutmeg, pimento, lemongrass, tarragon, basil, star anise, and fennel. Methyleugenol has been shown to inhibit histone deacetylase (HDAC) activity in the human colon carcinoma cell line HT29. Compounds that exhibit HDAC-inhibitory properties or disrupt the HDAC complex have potential applications in cancer therapy and chemoprevention. In addition, Methyleugenol is a flavoring agent often used in consumer products such as jellies, baked goods, beverages,chewing gums, ice cream, and fragrance.<br>References Groh, I. A., et al.: J Nutr Metab. 2013, 821082 (2013); R. L. Smith, et al.: Food Chem Toxicol 40, 851 (2002)<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>