Nucleosidi e Nucleotidi
I nucleosidi sono composti formati da una base azotata legata a uno zucchero (ribosio o desossiribosio). Quando un gruppo fosfato viene aggiunto al nucleoside, si forma un nucleotide. Questi composti sono fondamentali nella biologia cellulare, poiché i nucleotidi sono i mattoni essenziali del DNA e dell’RNA, responsabili dell’archiviazione e della trasmissione delle informazioni genetiche. I nucleosidi trovano applicazione nel trattamento delle malattie virali, agendo come inibitori della replicazione virale. I nucleotidi, oltre al loro ruolo strutturale negli acidi nucleici, sono coinvolti nei processi energetici, come la sintesi dell’ATP.
Presso CymitQuimica, offriamo un’ampia gamma di nucleosidi e nucleotidi essenziali per la ricerca in biologia molecolare, virologia e farmacologia.
Trovati 3424 prodotti di "Nucleosidi e Nucleotidi"
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O,O'-Dipropanal Ganciclovir
CAS:Prodotto controllato<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>Formula:C15H21N5O6Colore e forma:NeatPeso molecolare:367.36N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine
CAS:Prodotto controllato<p>Applications N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine is used for developing platelet P2T receptor antagonists, which have potential applications for antithrombotic therapy.<br>References Ingall, A. H., et al.: J. Med. Chem. 42, 213 (1999)<br></p>Formula:C16H22F3N5O4S2Colore e forma:NeatPeso molecolare:469.56-Deoxypenciclovir hydrochloride
CAS:<p>Applications Hydrochloride salt metabolite of a metabolite of Famciclovir, an antiviral.<br>References Harnden, M.R., et al.: J. Med. Chem., 32, 1738 (1989)<br></p>Formula:C10H15N5O2·ClHColore e forma:White SolidPeso molecolare:273.72UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt (90%)
CAS:Prodotto controllato<p>Applications UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt is a lipid A precursor for Escherichia coli.<br>References Anderson, M. S. et al.: Biochem., 27, 1908 (1988);<br></p>Formula:C35H64N4O22P2Purezza:90%Colore e forma:NeatPeso molecolare:954.84N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine
CAS:Prodotto controllato<p>Applications N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine is used for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Formula:C21H27N2O7PColore e forma:NeatPeso molecolare:450.422Adenosine
CAS:<p>Applications Adenosine is a nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Formula:C10H13N5O4Colore e forma:NeatPeso molecolare:267.24Melphalan-d8 Dihydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Formula:C13H12D8Cl4N2O2Colore e forma:NeatPeso molecolare:386.17Cladribine 5’-Monophosphate Ammonium (>85%)
CAS:Prodotto controllato<p>Applications Cladribine 5’-Monophosphate Ammonium Salt can be used as an antiviral, antibacterial and antileukemic agent.<br>References Cook, P., et al.: U.S., US 4719295 A 19880112 (1988);<br></p>Formula:C10H16ClN6O6PPurezza:>85%Colore e forma:NeatPeso molecolare:382.7Thymine
CAS:Prodotto controllato<p>Impurity Zidovudine EP Impurity C<br>Applications Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA.<br>References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008); Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009); Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009);<br></p>Formula:C5H6N2O2Colore e forma:WhitePeso molecolare:126.11Zanamivir Amine
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A synthetic precursor of Zanamivir.<br>References Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Bergmann, R., et al.: J. Med. Chem., 50, 2708 (2007), Lue, W., et al.: Eur. J. Med. Chem., 43, 569 (2008),<br></p>Formula:C11H18N2O7Colore e forma:NeatPeso molecolare:290.276-Methylmercaptopurine
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.<br>References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),<br></p>Formula:C6H6N4SColore e forma:White To BeigePeso molecolare:166.20Cytarabine 5’-Monophosphate
CAS:Prodotto controllato<p>Stability Hygroscopic, Unstable in Solution<br>Applications A derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Formula:C9H14N3O8PColore e forma:NeatPeso molecolare:323.204-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
CAS:Prodotto controllato<p>Applications 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene is used as a reagent in the synthesis of Dapagliflozin (D185370); a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.<br>References Meng, W., et al.: J. Med. Chem., 51, 1145 (2008);<br></p>Formula:C15H14BrClOColore e forma:White To Off-WhitePeso molecolare:325.63Pteroic Acid (>85%)
CAS:Prodotto controllato<p>Impurity Methotrexate EP Impurity D N-Desmethyl Impurity<br>Applications Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.<br>References Vickers, P.J. et al.: Can. J. Biochem. Cell Biol., 63, 777 (1985): Tafolla, W.H. et al.: J. Pharmac. Sci., 70, 1273 (1981); Iwai, K. et al.: J. Butrit. Sci. Vitaminol., 23, 95 (1977);<br></p>Formula:C14H12N6O3Purezza:>85%Colore e forma:NeatPeso molecolare:312.285-Amino-1-methyl-4-nitroimidazole
CAS:Prodotto controllato<p>Applications 5-Amino-1-methyl-4-nitroimidazole is a moiety of Azathioprine (A803350); an immunosuppressive antimetabolite that is also active as a disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979); Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979); Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987); Sandborn, W.J., et al.: Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998)<br></p>Formula:C4H6N4O2Colore e forma:NeatPeso molecolare:142.12Methyl 1,2,4-Triazole-3-carboxylate
CAS:Prodotto controllatoFormula:C4H5N3O2Colore e forma:Off-WhitePeso molecolare:127.1Gemcitabine
CAS:<p>Applications Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer.<br>References Hamsici, S., et al.: Bioconjugate Chem., (2017); Peng, T., et al.: J. Cell. Biochem., (2017)<br></p>Formula:C9H11F2N3O4Colore e forma:Off-WhitePeso molecolare:263.22-Deoxy-D-ribose
CAS:Prodotto controllato<p>Applications 2-Deoxy-D-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.<br>References Fico, A., et al.: Free Radical Biology & Medicine, 45, 211 (2008),<br></p>Formula:C5H10O4Colore e forma:NeatPeso molecolare:134.13Melphalan
CAS:Prodotto controllato<p>Applications Melphalan is an antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Formula:C13H18Cl2N2O2Colore e forma:NeatPeso molecolare:305.206-O-Methylguanine
CAS:Prodotto controllatoFormula:C6H7N5OColore e forma:Off-WhitePeso molecolare:165.155’-O-Acetyl Ribavirin
CAS:Prodotto controllato<p>Applications 5’-O-Acetyl Ribavirin is an impurity of Ribavirin (R414475). Ribavirin impurity F.<br>References Zakharieva., et al.: Bioorganic. Medicinal. Chem., 1994, 4, 2831 (1994), Reichard., et al.: The Lancet, 351, 83 (1998),<br></p>Formula:C10H14N4O6Colore e forma:NeatPeso molecolare:286.24Iso Cytosine
CAS:Prodotto controllato<p>Applications A useful intermediate for chemical modifications of base and sugar moieties in natural nucleosides.<br>References Sashaki, T., et al.: J. Org. Chem., 40(1), 106 (1975)<br></p>Formula:C4H5N3OColore e forma:NeatPeso molecolare:111.103'-Azido-3'-deoxy-5'-O-tritylthymidine
CAS:Prodotto controllatoFormula:C29H27N5O4Colore e forma:NeatPeso molecolare:509.56Lamivudine Triphosphate Triethylamine Salt (90%)
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A metabolite of Lamivudine (L172500).<br>References Burgess, K., et al.: Chem. Rev., 100, 2047 (2000), Gallois-Montbrun, S., et al.: Biochem. Pharmacol., 68, 1749 (2004),<br></p>Formula:C8H14N3O12P3SC6H15NxPurezza:90%Colore e forma:NeatPeso molecolare:469.2010119Guanine
CAS:<p>Impurity Aciclovir EP Impurity B<br>Applications Guanine is one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. Aciclovir EP Impurity B.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010);<br></p>Formula:C5H5N5OColore e forma:White To Off-WhitePeso molecolare:151.13Cytidine 5'-Diphosphocholine
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications Cytidine 5'-diphosphocholine (cas# 987-78-0) is a useful research chemical.<br></p>Formula:C14H26N4O11P2Colore e forma:Off-WhitePeso molecolare:488.32Emtricitabine-13C,15N2
CAS:Prodotto controllato<p>Stability Very Hygroscopic<br>Applications Labelled Emtricitabine. A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>Formula:CC7H10F15N2NO3SColore e forma:White To Light YellowPeso molecolare:250.23Melamine (1 mg/10 mL in 84:16% ACN:H2O)
CAS:Prodotto controllatoFormula:C3H6N6Colore e forma:Single SolutionPeso molecolare:126.122-Amino-6-(chloromethyl)-4(3H)-pteridinone (>90%)
CAS:Prodotto controllato<p>Applications 2-Amino-6-(chloromethyl)-4(3H)-pteridinone is a reagent/intermediate used in the preparation of Folic Acid (F680300) and its derivatives.<br>References Qi, Y., et al.: Faming Zhuanli Shenqing. CN 103755706 A 20140430. Apr 30, 2014;<br></p>Formula:C7H6ClN5OPurezza:>90%Colore e forma:NeatPeso molecolare:211.616-Benzylaminopurine 9-(β-D-glucoside)
CAS:<p>Applications 6-Benzylaminopurine 9-(β-D-glucoside) (cas# 4294-17-1) is a compound useful in organic synthesis.<br></p>Formula:C18H21N5O5Colore e forma:NeatPeso molecolare:387.39Iso Ribavirin (Ribavirin Impurity G)
CAS:Prodotto controllatoFormula:C8H12N4O5Colore e forma:NeatPeso molecolare:244.2Phosphoric Acid Dibenzyl Ester
CAS:<p>Stability Moisture Sensitive<br>Applications Eye irritant.<br>References Bagley, D. M. et al.; Toxicol. In Vitro 13, 505 (1999); Gilleron, L. et al.; Toxicol. In Vitro 11, 641 (1997)<br></p>Formula:C14H15O4PColore e forma:NeatPeso molecolare:278.24Adenine
CAS:Prodotto controllato<p>Applications Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coalaninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer.<br>References Philips, et al.: J. Pharmacol. Exp. Ther., 20, 104 (1952), Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),<br></p>Formula:C5H5N5Colore e forma:Light YellowPeso molecolare:135.135-Fluorodihydropyrimidine-2,4-dione
CAS:Prodotto controllato<p>Applications A metabolite of 5-Fluorouracil. (F596000)<br>References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)<br></p>Formula:C4H5FN2O2Colore e forma:NeatPeso molecolare:132.093Levomefolic Acid
CAS:<p>Applications A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.<br>References Willems, F. et al.: Br. J. Pharmacol., 145, 823 (2004); Prinz-Langhebohi, R.: et al., Br. J. Pharmacol., 158, 2014 (2009); Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010)<br></p>Formula:C20H25N7O6Colore e forma:NeatPeso molecolare:459.46Melphalan-d8 Monohydrochloride
CAS:Prodotto controllatoFormula:C13H10D8Cl2N2O2·HClColore e forma:WhitePeso molecolare:349.71Cytarabine-13C3
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.<br>References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)<br></p>Formula:C613C3H13N3O5Colore e forma:BeigePeso molecolare:246.19Thymidine
CAS:Prodotto controllato<p>Applications Constituent of deoxyribonucleic acid.<br>References Levene, L., et al.: J. Bil. Chem. 83, 793 (1929), Tollin, et al.: Nature 217, 1148 (1968), Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009), Hazra, S., et al.: Biochem., 48, 1256 (2009), Yang, I., et al.: J. Biol. Chem., 284, 191 (2009),<br></p>Formula:C10H14N2O5Colore e forma:White To Off-WhitePeso molecolare:242.23Adenosine 5'-monophosphate monohydrate
CAS:Prodotto controllatoFormula:C10H14N5O7P·H2OColore e forma:NeatPeso molecolare:365.2310-Formyl Folic Acid-d4
CAS:Prodotto controllato<p>Stability Air Sensitive<br>Applications A labelled Folic acid (F680300) derivative (or folate) found in daily dietary intake that is often used in cancer risk correlation studies.<br>References Keszei, A.P. et al.: Cancer Epidimiol. Biomarker Prev., 18, 1785 (2009); Koning, E.J. et al.: Cancer, 95, 1421 (2002);<br></p>Formula:C20H15D4N7O7Colore e forma:NeatPeso molecolare:473.43Zanamivir-13C,15N2
CAS:Prodotto controllato<p>Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.<br>References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),<br></p>Formula:CC11H2015N2N2O7Colore e forma:NeatPeso molecolare:335.294-Desethoxy-2-ethoxy Dapagliflozin, >90%
CAS:Prodotto controllato<p>Applications (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(2-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Formula:C21H25ClO6Purezza:>90%Colore e forma:NeatPeso molecolare:408.87Abacavir 5’-β-D-Glucuronide Sodium Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formula:C20H25N6NaO7Colore e forma:NeatPeso molecolare:484.44Fenretinide
CAS:Prodotto controllato<p>Stability Light Sensitive - Protect from Light Exposure<br>Applications Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.A synthetic analog of Vitamin A.<br>References Marth, C., et al.:J. Nat. Cancer Inst., 75, 871 (1985), Delia, D., et al.: Cancer Res., 53, 6036 (1993), Costa., A., et al.: Cancer Res., 54, Suppl., 2032s (1994), Decensi., A., et al.: Eur. J. Cancer Prev., 3, 377 (1994)<br></p>Formula:C26H33NO2Colore e forma:NeatPeso molecolare:391.551-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one
CAS:Prodotto controllato<p>Stability Moisture Sensitive<br>Applications 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one is an impurity of 5-Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Formula:C10H14N4O6Colore e forma:White To Off-WhitePeso molecolare:286.24Capecitabine
CAS:Prodotto controllato<p>Applications Capecitabine is an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).<br>References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>Formula:C15H22FN3O6Colore e forma:NeatPeso molecolare:359.35N,O-Diacetate Isoacyclovir
CAS:Prodotto controllato<p>Impurity Aciclovir EP Impurity M<br>Applications An impurity of Acyclovir. Aciclovir EP Impurity M<br>References Laskin, O., et al.: Clin. Pharmacok., 8, 187 (1983), Grass, G., et al.: Pharm. Res., 5, 372 (1988), Mahony, W., et al.: J. Biol. Chem., 263, 9285 (1988), Merino, V., et al.: J. Pharm. Sci., 84, 777 (1995),<br></p>Formula:C12H15N5O5Colore e forma:NeatPeso molecolare:309.2785’-Ethylcarboxamido Adenosine
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cusack and Hourani: Br. J. Pharmacol., 72, 433 (1981), Knapp, et al.: Pharmacol. Biochem. Behav., 68, 797 (2001)<br></p>Formula:C12H16N6O4Colore e forma:NeatPeso molecolare:308.29Cidofovir Diphosphate Trisodium Salt (>85%)
CAS:Prodotto controllato<p>Applications Cidofovir Diphosphate Trisodium Salt has antiviral activity, which is used against herpes viruses. Cidofovir Diphosphate is a metabolite in human cells.<br>References Hitchcock, M. J. M., et al.: Antivir. Chem. Chemoth., 7, 115-127 (1996); Cihlar, T., et al.: Collect. Czech. Chem. C., 57, 661-72 (1992)<br></p>Formula:C8H13N3Na3O12P3Purezza:>85%Colore e forma:NeatPeso molecolare:505.0925-Methyluridine
CAS:<p>Applications A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.<br>References Borek, E., et al.: Cancer Res., 37, 3362 (1977), Sander, G., et al.: Clin. Sci.,71, 367 (1986), Sander, G., et al.: Ann. Nutr. Metab., 30, 137 (1986), Rasmuson, T., et al.: Acta Oncol., 34, 61 (1995),<br></p>Formula:C10H14N2O6Colore e forma:NeatPeso molecolare:258.23Adenosine 5'-Monophosphate
CAS:Prodotto controllato<p>Applications Adenosine 5'-Monophosphate is a natural occurring nucleotide and a useful ligand determinant that facilitate the binding of APS reductase inhibitors and activates adenosine receptor agonists.<br>References Hong, J.A. et al.: J. Med. Chem., 52, 5485 (2009); Korboukh I. et al.: J. Med. Chem., 55, 6467 (2012)<br></p>Formula:C10H14N5O7PColore e forma:NeatPeso molecolare:347.225-Methyl-2’-deoxy Cytidine
CAS:<p>Applications A Cytidine (C998300) analog and also an isostere of Thymidine (T412000).<br>References Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008),<br></p>Formula:C10H15N3O4Colore e forma:NeatPeso molecolare:241.243’-Amino-3’-deoxythymidine
CAS:Prodotto controllato<p>Impurity Zidovudine Impurity;<br>Stability Hygroscopic, Moisture Sensitive<br>Applications A metabolite of Zidovudine (3'-Azido-3'-deoxythymidine; AZT).<br>References Qian, M., et al.: Biochem. Pharmacol., 48, 383 (1994), Diwan, B., et al.: Toxicol. Appl. Pharmacol., 161, 82 (1999) , Lim, S., et al.: J. Biol. Chem., 276, 23616 (2001), Von Tungeln, L., et al.: Carcinogenesis, 23, 1427 (2002),<br></p>Formula:C10H15N3O4Colore e forma:White To Off-WhitePeso molecolare:241.24Entecavir-13C2,15N
CAS:Prodotto controllato<p>Applications Labelled Entecavir. An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.<br>References Innaimo, S.F., et al.: Antimicrob. Agents Chemother., 41, 1444 (1997), Honkoop, P., et al.: Expert Opin. Invest. Drugs, 12, 683 (2003), Chang, T.-T., et al.: N. Engl. J. Med., 354, 1001 (2006),<br></p>Formula:C1013C2H15N415NO3Colore e forma:White To Off-WhitePeso molecolare:280.264’-Epi Lamivudine
CAS:Prodotto controllato<p>Applications Lamivudine epimer.<br>References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993),<br></p>Formula:C8H11N3O3SColore e forma:NeatPeso molecolare:229.26RO 2433
CAS:Prodotto controllato<p>Impurity Sofosbuvir Metabolite GS331007<br>Applications RO 2433 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.<br>References Asif, G., et. al.: Antimicrob. Agents Ch., 51, 2877 (2007)<br></p>Formula:C10H13FN2O5Colore e forma:NeatPeso molecolare:260.223’,5’-Di-O-benzyl Entecavir
CAS:Prodotto controllato<p>Applications 3’,5’-Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900).<br>References Li, R. et al.: Zhong. Yao., 6, 292 (2008); Bisacchi, G.S. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997);<br></p>Formula:C26H27N5O3Colore e forma:NeatPeso molecolare:457.52cis 5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)- pyrimidinedione
CAS:Prodotto controllato<p>Applications Antiviral nucleoside analog, also an impurity found in emtricitabine (E525000).<br>References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993),<br></p>Formula:C8H9FN2O4SColore e forma:Off-WhitePeso molecolare:248.23Folic Acid-13C5
CAS:<p>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>Formula:C5C14H19N7O6Colore e forma:Dark Yellow To Dark BrownPeso molecolare:446.362-Oxa-1,4-butanediol diacetate
CAS:Prodotto controllatoFormula:C7H12O5Colore e forma:NeatPeso molecolare:176.17trans-Abacavir Dihydrochloride
CAS:Prodotto controllato<p>Applications trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formula:C14H18N6O·2HClColore e forma:NeatPeso molecolare:359.25Adenosine 5’-Monophosphoramidate Sodium Salt
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications Used in the characterization and elucidation of coordination requirements of adenine nucleotides complexes with Fe(II) ions.<br>References Richter, Y., et al.: Nucleos. Nucleot. Nucleic Acids, 22, 1757 (2003),<br></p>Formula:C10H14N6O6P·NaColore e forma:NeatPeso molecolare:368.22O-Benzoyllamivudine
CAS:Prodotto controllatoFormula:C15H15N3O4SColore e forma:Off-WhitePeso molecolare:333.362N2-Acetyl Acyclovir
CAS:Prodotto controllato<p>Impurity Aciclovir EP Impurity F<br>Applications N2-Acetyl Acyclovir (Aciclovir EP Impurity F) is an impurity of Acyclovir (A192400).<br>References Balon, K., et al.: Pharm. Res., 16, 882 (1999),<br></p>Formula:C10H13N5O4Colore e forma:BeigePeso molecolare:267.245-Fluoro ent-Lamivudine Acid D-Menthol Ester
CAS:Prodotto controllato<p>Applications Intermediate in the synthesis of ent-Emtricitabine (E525005).<br></p>Formula:C18H26FN3O4SColore e forma:NeatPeso molecolare:399.486-Deoxypenciclovir
CAS:Prodotto controllato<p>Applications A metabolite of Famciclovir, an antiviral.<br>References Harnden, M.R., et al.: J. Med. Chem., 32, 1738 (1989)<br></p>Formula:C10H15N5O2Colore e forma:Off White SolidPeso molecolare:237.261R-Dapagliflozin
CAS:Prodotto controllato<p>Applications 1R-Dapagliflozin is an isomer of Dapagliflozin (D185370), which is a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Formula:C21H25ClO6Colore e forma:NeatPeso molecolare:408.883'-Deoxyinosine
CAS:Prodotto controllato<p>Impurity Didanosine EP Impurity D<br>Applications 3'-Deoxyinosine (Didanosine EP Impurity D) is an Inosine (I661000) analog with potential use as an antileishmanial drug. Used as an inhibiting agent in studies of Trypanosoma cruzi growth inside host cells in vitro. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950).<br>References Morishige, K. et al.: Exp. Parasitol., 80, 665 (1995); Aoki, T. et al.: Adv. Exp. Med. Biol., 370, 499 (1994);<br></p>Formula:C10H12N4O4Colore e forma:NeatPeso molecolare:252.23α-Decitabine
CAS:Prodotto controllato<p>Applications α-Decitabine is shown to inhibit DNA methylation resulting in an effective anticancer agent.<br>References Hajek, M. et al.: Biochem. Pharm., 75, 965 (2008); Rogstad, D. et al.: Chem. Res. Toxicol., 22, 1194 (2009);<br></p>Formula:C8H12N4O4Colore e forma:NeatPeso molecolare:228.212,4-Diamino-6-hydroxypyrimidine
CAS:Prodotto controllato<p>Applications 2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.<br></p>Formula:C4H6N4OColore e forma:NeatPeso molecolare:126.12Abacavir-d4
CAS:Prodotto controllato<p>Stability Very Hygroscopic<br>Applications Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Formula:C14H14D4N6OColore e forma:Off-WhitePeso molecolare:290.361’-epi-Cladribine
CAS:<p>Applications 1’-epi-Cladribine is an impurity of Cladribine (C557500), a substituted purine nucleoside with antileukemic activity.<br>References Seto, S., et al.: J. Clin. Invest., 75, 377 (1985), Piro, L.D., et al.: N. Engl. J. Med., 322, 1117 (1990),<br></p>Formula:C10H12ClN5O3Colore e forma:NeatPeso molecolare:285.69Floxuridine-13C,15N2
CAS:Prodotto controllato<p>Applications Labelled Floxuridine. Antiviral; antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harris, M., et al.: Biophys. J., 4, 203 (1964),<br></p>Formula:C813CH11F15N2O5Colore e forma:WhitePeso molecolare:249.17Melamine-15N3
CAS:<p>Applications Isotope labelled Melamine (M208703), which forms synthetic resins with formaldehyde. It remains largely non-metabolized in male Wistar rats with 90% of the administered dose excreted in the urine (1,2) and thus acts as a non-protein nitrogen food additive found in milk (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Mast, R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Smith, J. et al.: Toxicol Appl Pharmacol. 1994 Apr;125(2):296-308.3. Anirudhan, T. et al.: Food Chem. 2017 Jul 15;227:85-92.<br></p>Formula:C3H615N3N3Colore e forma:White To Off-WhitePeso molecolare:129.10Dapagliflozin hydroxy Impurity (Mixture of Diastereomers)
CAS:<p>Applications (1S)-1,5-anhydro-1-C-[4-Chloro-3-[(4-ethoxyphenyl)hydroxymethyl]phenyl]-D-glucitol is an impurity of the drug Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>Formula:C21H25ClO7Colore e forma:White To Off-WhitePeso molecolare:424.872Zanamivir
CAS:Prodotto controllato<p>Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.<br>References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),<br></p>Formula:C12H20N4O7Colore e forma:NeatPeso molecolare:332.31Adenosine-3’,5’-cyclic Monophosphate
CAS:<p>Stability Hygroscopic<br>Applications Adenosine-3’,5’-cyclic Monophosphate is an Adenosine (A280400) derivative useful as anticancer agent.<br>References Keast, R., et al.: Pharma. Res., 19, 1019 (2002),<br></p>Formula:C10H12N5O6PColore e forma:NeatPeso molecolare:329.21[1',2',3',4',5'-13C5]Uridine
CAS:Prodotto controllato<p>Applications Labelled Uridine, a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA)<br>References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Grakoui, A., et al.: J. Virol., 63, 5216 (1989); Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994); Lin, Y., et al.: Virology, 292, 78 (2002);<br></p>Formula:C5C4H12N2O6Colore e forma:NeatPeso molecolare:249.16Etravirine
CAS:Prodotto controllato<p>Applications Etravirine is a novel HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>Formula:C20H15BrN6OColore e forma:White To Off-WhitePeso molecolare:435.28Baquiloprim
CAS:<p>Stability Hygroscopic<br>Applications Baquiloprim is an amiopyrimidine antibacterial synergist with high activity and slow elimination. Baquiloprim has a better half-life than trimethoprim.<br>References Zhi-hui, H., et al.: Anhui Nongye Kexue, 41, 2503 (2013)<br></p>Formula:C17H20N6Colore e forma:Light YellowPeso molecolare:308.382’-Deoxycytidine 5'-Monophosphate Hydrate
CAS:Prodotto controllato<p>Applications A phosphorylated metabolite of the deoxyribonucleoside 2’-Deoxycytidine. A constituent of Deoxyribonucleic acid. Studies show that it increases influenza virus antigen-induced immune cell proliferation.<br>References Holen, E. et al.: Nutrition, 21, 1003 (2005); Alexandre, J.A. et al.: Nucleosides Nucleotides Nucelic Acids, 26, 1375 (2007);<br></p>Formula:C9H14N3O7P·xH2OColore e forma:White To Off-WhitePeso molecolare:307.20 + x(18.02)Gemcitabine-13C,15N2 Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications Labelled Gemcitabine, an antineoplastic.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Formula:C813CH12ClF2N15N2O4Colore e forma:Off-WhitePeso molecolare:302.64D-Glucono-1,5-lactone
CAS:Prodotto controllato<p>Applications A lactone (cyclic ester) of D-gluconic acid used as a used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent.<br>References Jacob, M. et al.: Food Hydrocoll., 25, 928 (2011); Li, J. et al.: J. Sci. Food Agric., 91, 38, 2011;<br></p>Formula:C6H10O6Colore e forma:NeatPeso molecolare:178.142’,2’-Difluoro-2’-deoxyuridine
CAS:Prodotto controllatoFormula:C9H10F2N2O5Colore e forma:White To Off-WhitePeso molecolare:264.184-[(2-Chloroethyl)amino]-L-phenylalanine Dihydrochloride
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications 4-[(2-Chloroethyl)amino]-L-phenylalanine is a metabolite of Melphalan (M216900); an antineoplastic.<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966); Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980)<br></p>Formula:C11H15ClN2O2HClColore e forma:NeatPeso molecolare:242.702Dapagliflozin Tetraacetate
CAS:<p>Applications Dapagliflozin Tetraacetate is a derivative of Dapagliflozin [D226255], a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011); Bernhardson, D. et al.: Org. Proc. Res. Dev., 18, 57 (2014);<br></p>Formula:C29H33ClO10Colore e forma:WhitePeso molecolare:577.02ent-Entecavir
CAS:Prodotto controllato<p>Applications ent-Entecavir is an enantiomeric impurity of the antiviral drug Entecavir (E558900).<br>References Ruediger, E. et al.: Tetrahed. Lett., 45, 739 (2004): Bisacchi, G.S. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997);<br></p>Formula:C12H15N5O3Colore e forma:NeatPeso molecolare:277.28N-Carbamoyl-2-fluoro-(β)-alanine
CAS:Prodotto controllato<p>Applications A metabolite of Capecitabine.<br>References Arellano, M., ET AL.: Br. J. Cancer, 77, 79 (1998), Budman, D., ET AL.: J. Clin. Oncol., 16, 1795 (1998), Khanna, R., et al.: Cancer Res., 60, 4725 (2000), Charasson, V., et al.: Drug Metab. Dispos., 30, 731 (2002),<br></p>Formula:C4H7FN2O3Colore e forma:NeatPeso molecolare:150.11Viaminate
CAS:Prodotto controllato<p>Applications Viaminate is a pharmaceutical used to treat severe acne and other keratinization disorders. Viaminate can be taken orally, or topically in prepared gels and creams.<br>References Zhang, H.; et al.: Am. J. Med. Sci., 356, 84 (2018); Lu, J.; et al.: Zhongguo Yaofang, 22, 155 (2011); Li, G.: Zhonghua Yiyao Zazhi, 7, 536 (2007).<br></p>Formula:C29H37NO3Colore e forma:Light YellowPeso molecolare:447.61Canagliflozin 2-Glucuronide
CAS:Prodotto controllato<p>Applications Canagliflozin 2-glucuronide is a derivative of Canagliflozin (C175190). Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion.<br>References Devineni, D., et al.: Diab. Obes. Metab., 14, 539 (2012); Nicolle, L., et al.: Curr. Med. Res. Opin., 28, 1167 (2012)<br></p>Formula:C30H33FO11SColore e forma:NeatPeso molecolare:620.64Penciclovir
CAS:<p>Applications An antiviral.<br>References Weinberg, A., et al.: Antimicrob. Ag. Chemother., 36, 2037 (1992), McMeekin, J.R., et al.: Anal. Proc., 29, 178 (1992),<br></p>Formula:C10H15N5O3Colore e forma:NeatPeso molecolare:253.265-Fluoro Cytosine
CAS:Prodotto controllato<p>Applications 5-FC is a toxic antifungal/antimicrobial agent.<br>References Gopinath, P., et al.: Biotechnol. Lett., 30, 1913 (2008), Kalkanci, A., et al.: Microbiol Immunol., 52, 435 (2008), Dubeau, M., et al.: App. Env. Microbiol., 75, 1211 (2009),<br></p>Formula:C4H4FN3OColore e forma:White To Off-WhitePeso molecolare:129.09α-Decitabine-3',5'-bis(4-chlorobenzoate)
CAS:Prodotto controllatoFormula:C22H18Cl2N4O6Colore e forma:White To Off-WhitePeso molecolare:505.308Adenosine-13C5
CAS:<p>Stability Hygroscopic<br>Applications Labelled nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010), Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010),<br></p>Formula:C513C5H13N5O4Colore e forma:White To Off-WhitePeso molecolare:272.20N-Des-1-β-D-ribofuranosyl Ribavirin
CAS:<p>Impurity Ribavirin EP Impurity D<br>Applications N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Formula:C3H4N4OColore e forma:Off White SolidPeso molecolare:112.09
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