Nucleosidi e Nucleotidi

Stability Hygroscopic, Temperature Sensitive
Applications A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism.
References Knowles, J., et al.: Annu. Rev. Biochem., 49, 877 (1980),

Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.
References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);

Stability Hygroscopic
Applications A labelled derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.
References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),

Impurity Aciclovir EP Impurity P
Applications 9-(2-Hydroxyethyl)guanine (Aciclovir EP Impurity P) is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor.
References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);

Applications Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.
References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)

Impurity Ribavirin EP Impurity C
Applications 1,2,4-Triazole-3-carboxylic Acid (Ribavirin EP Impurity C) is a major metabolite of the antiviral agent Ribavirin (R414475).
References Miller, J.P. et al.: Ann. N.Y. Acad. Sci., 284, 211 (1977); Catlin, D. et al.: Ribavirin: Broad Spec. Antivir. Ag., 83 (1980); Lin, C.C. et al.: Antimicrob. Ag. Chemother., 50, 2368 (2006);

Applications 9-Carboxymethoxymethylguanine is a metabolite of Acyclovir (A192400) which is an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses.
References Gunness, P., et al.: Transl. Res., 158, 290 (2011); Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979), Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988), Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992),

Applications 2-Hydroxytetrahydrofuran (cas# 5371-52-8) is a compound useful in organic synthesis.

Applications Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015);

Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B
Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.
References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)

Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-

Stability Hygroscopic
Applications A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.
References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010);

Applications A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),

Stability Hygroscopic
Applications Ademethionine 1,4-Butanedisulfonate is used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.

Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),