APIs per la ricerca e le impurità
I principi attivi farmaceutici (API) sono le sostanze nei farmaci responsabili dei loro effetti terapeutici. In questa sezione troverai una vasta gamma di API destinati all'uso in ricerca. Questi composti sono essenziali per lo sviluppo, il test e la validazione di nuove formulazioni farmaceutiche. Presso CymitQuimica, offriamo API di alta qualità per supportare la ricerca nella scoperta e nello sviluppo di farmaci.
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- Aminoacidi e Derivati(12.440 prodotti)
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- Nitrili e Derivati Ciano(3.070 prodotti)
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Cetirizine glycerol ester impurity
CAS:Cetirizine glycerol ester impurity is a drug product that is an analytical impurity. It is a natural, API impurity, and synthetic. The CAS number for this impurity is 1243652-36-9. Research and Development (R&D) of cetirizine glycerol ester impurity is required for the manufacture of pharmaceutical products. High purity cetirizine glycerol ester impurity can be used as a pharmacopoeia standard for HPLC analyses.Formula:C24H31ClN2O5Purezza:Min. 95%Peso molecolare:462.97 g/mol2-EPIIvermectin B1a
2-EPIivermectin B1a is a drug product that is used as an analytical standard for the detection of impurities in API and in the synthesis of Metabolite. It is also used as a natural product for drug development. 2-EPIivermectin B1a is not intended for use as an active pharmaceutical ingredient. This product has been shown to have pharmacopoeia purity, which means it meets the specifications set by the following organizations: USP, EP, JP, BP, and CP.Purezza:Min. 95%Simvastatin hydroxy acid ethyl ester
CAS:Simvastatin hydroxy acid ethyl ester is a solvated form of simvastatin, an investigational drug for the treatment of dyslipidemia. The ammonium salt was prepared by alcoholysis with ethanol. The elution process was carried out using an acetonitrile-water mixture and chromatography on silica gel. Preparation methods were investigated to determine the best preparative procedure that would yield pure material. This compound has been investigated as a possible therapeutic agent for the treatment of midbody diseases such as familial amyloidotic polyneuropathy and Alzheimer's disease.Formula:C27H44O6Purezza:Min. 95%Colore e forma:Colourless To Pale Yellow LiquidPeso molecolare:464.63 g/molCefpodoxime proxetil impurity H
CAS:Cefpodoxime proxetil impurity H is an impurity of cefpodoxime proxetil, which is a prodrug that has been shown to be metabolized by esterases to the active form cefpodoxime. Cefpodoxime proxetil impurity H was found in the elution fraction when using liquid chromatography with reversed-phase as the separation method. It is thought that this impurity may arise from the use of methanol in the process of preparing cefpodoxime proxetil, although other mechanisms have not been ruled out. The mass spectrum for cefpodoxime proxetil impurity H shows peaks at m/z 812 and 682, which correspond to the parent drug and its hydrolysis product, respectively. The fragmentation pattern observed for cefpodoxime proxetil impurity H corresponds to that seen for cephalosporins.Formula:C42H54N10O18S4Purezza:Min. 95%Peso molecolare:1,115.2 g/mol3-O-Desmethyl amlodipine
CAS:3-O-Desmethyl amlodipine is a metabolite of the drug amlodipine. It has been shown to be formed in vivo and may contribute to the pharmacological activity of amlodipine, although its contribution is not well understood. 3-O-Desmethyl amlodipine has been used as an analytical standard for chemical purity testing of pharmaceuticals, and as an impurity standard for HPLC analysis.Formula:C19H23ClN2O5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:394.85 g/mol(S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine)
(S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine) is an API impurity. CAS No. for this product is not available. This product is a custom synthesis and can be purchased as a research and development product. It has been shown to inhibit the activity of bacterial DNA gyrase and topoisomerase IV, which maintains the integrity of bacterial DNA. The chemical name for this product is (S)-N2-(Methoxymethyl)-N6-proply-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6 diamine).Formula:C12H23N3OSPurezza:Min. 95%Peso molecolare:257.4 g/mol4-(2-Methoxyethyl)phenol
CAS:4-(2-Methoxyethyl)phenol is a synthetic compound that is an antihypertensive agent. It is used to reduce high blood pressure, which may be due to its ability to block the action of angiotensin II, a potent vasoconstrictive hormone, by binding with its receptor. 4-(2-Methoxyethyl)phenol has been shown to be more potent than metoprolol succinate and less toxic than hydroxylated compounds such as propranolol in pharmacokinetic studies. In addition, 4-(2-Methoxyethyl)phenol has been found to have a low risk of congestive heart failure. The industrial process for this substance involves the reaction of hydrochloric acid with phenol in the presence of a catalyst such as aluminium chloride or zinc chloride.
Formula:C9H12O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:152.19 g/molN,N-Dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine
CAS:Prodotto controllatoThe synthesis of N,N-dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine is a two step process. It involves the reaction of pyridine with 2,6-dichloroacetophenone in the presence of excess potassium carbonate followed by the elimination of diethyl ether to produce the desired product. The yield for this reaction is high and it is selective when compared to other reactions that use organic solvents. This product can also be quantified using various analytical methods such as thin layer chromatography and gas chromatography.Formula:C17H22N2OPurezza:Min. 95%Colore e forma:Clear LiquidPeso molecolare:270.37 g/molMethyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside
CAS:Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is a synthetic impurity standard for the drug product. It has been used in studies on metabolism and as an analytical reference material. Methyl 2-deoxy-3,4-di-O-toluoyl-D-ribopyranoside is also available as a custom synthesis at high purity.Formula:C22H24O6Purezza:Min. 95%Colore e forma:White powder.Peso molecolare:384.42 g/molAtorvastatin lactone
CAS:Atorvastatin lactone is a prodrug for atorvastatin. It is an inhibitor of the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis and reduces LDL cholesterol levels. Atorvastatin lactone is absorbed from the gut into the bloodstream and then converted to atorvastatin, which has a higher potency than atorvastatin lactone. This conversion occurs in the liver by cytochrome P450 enzymes, including cytochrome CYP3A4. The pharmacokinetics of atorvastatin lactone are influenced by drugs that inhibit these enzymes. Atorvastatin and its metabolites are excreted in human serum as glucuronide or sulfate conjugates.Formula:C33H33FN2O4Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:540.62 g/mola-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-α-ethyl-3,4-dimethoxy-benzeneacetonitrile
CAS:a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-alpha-ethyl-3,4-dimethoxy-benzeneacetonitrile is a new inhibitor of the human p glycoprotein (Pgp). It has been shown to inhibit the function of Pgp in vitro and in vivo. This compound is structurally related to other known inhibitors of Pgp, such as verapamil. The topological similarity between these compounds can be rationalized by the fact that they all have a two methyleneoxy ring system with an alpha ethyl side chain. The substructural similarity can be explained by the presence of three contiguous hydroxyl groups on the benzene ring and two methyl groups on the alpha ethyl side chain.Formula:C26H36N2O4Purezza:Min. 95%Peso molecolare:440.58 g/molDehydroxy bisoprolol
CAS:Dehydroxy bisoprolol is an impurity of the drug Bisoprolol that is used to make the drug product Metoprolol. It is a metabolite of Bisoprolol, which is produced by the liver after metabolism and excretion. Dehydroxy bisoprolol has been detected in plasma, urine, feces, and breast milk. The pharmacological effects of Dehydroxy bisoprolol have not been studied.
Formula:C18H29NO3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:307.43 g/molPantoprazole N-oxide sodium
CAS:Pantoprazole N-oxide sodium is a custom synthesis drug product that is being developed as an impurity standard in the synthesis of Pantoprazole. The compound is also used as a pharmacopoeia analytical standard and a HPLC standard.Formula:C16H15F2N3O5S·NaPurezza:Min. 95%Colore e forma:PowderPeso molecolare:422.36 g/mol3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
CAS:3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid is a chemical compound that is an impurity standard for HPLC. It is also used as a pharmacopoeia, drug development, and analytical reference standard. The CAS number for this compound is 66364-71-4. This compound has been shown to be metabolized by microsomal oxidation, glucuronidation, or sulfation pathways in humans. 3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid can also be found in natural sources such as plants and animals.Formula:C18H14N4O5SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:398.39 g/molLisinopril EP Impurity E
CAS:Lisinopril EP Impurity E is an impurity of lisinopril, which is a prescription drug used to treat high blood pressure. This impurity was found in a preparative high performance liquid chromatography (HPLC) and mass spectroscopy analysis of the drug. The molecular weight of Lisinopril EP Impurity E was determined to be 317.2 amu, which corresponds to the molecular formula C7H13NO2. The FT-IR spectrum showed that this impurity has an ammonium group at 1859 cm-1 and butanoic acid at 1647 cm-1.Formula:C21H31N3O5Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:405.49 g/molDehydrocorybulbine chloride
CAS:Dehydrocorybulbine chloride salt is a medicinal compound that has shown potential as an anticancer agent. It is an analog of the Chinese herb Corydalis yanhusuo and has been found to inhibit protein kinases, which are enzymes that play a key role in cancer cell growth and proliferation. Dehydrocorybulbine chloride salt has been shown to induce apoptosis (programmed cell death) in various types of cancer cells, including bladder, lung, and breast cancer cells. This compound also exhibits low toxicity towards normal human cells and has shown promise as a possible treatment for certain types of cancer.Formula:C21H22ClNO4Purezza:Min. 95%Colore e forma:PowderPeso molecolare:352.4 g/molIsoribavirin
CAS:Isoribavirin is a ribonucleoside monophosphate analog that inhibits viral RNA polymerase. Isoribavirin has been shown to be active against influenza virus, herpes simplex virus, and vesicular stomatitis virus in cell culture. Isoribavirin is stable in an acetonitrile solution in the presence of phosphoric acid at pH 3-4 or in the presence of sulfate ions at pH 9-10. It can be purified by chromatography on a silica gel column using an acetonitrile/water mobile phase gradient. The impurities of isoribavirin are not detectable by liquid chromatography and have no significant effect on its sensitivity. Isoribavirin elutes from the silica gel column with the impurities.
Formula:C8H12N4O5Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:244.21 g/mol6'-Methoxy-2'-acetonaphthone
CAS:6'-Methoxy-2'-acetonaphthone is a reactive chemical that can be used as a reagent in organic synthesis. It is an electron-rich aromatic compound and its reactivity is enhanced by electron-donating groups such as -OH, -NH2, or -SH. 6'-Methoxy-2'-acetonaphthone can be used to form new carbon-carbon bonds in the presence of metal catalysts. This reaction can be done in either the presence or absence of a solvent, although the yield is better when carried out in organic solvents. Oxime derivatives are formed as oxidation products during this reaction. Acetylation may also occur, which would produce acetophenones or phenylacetones.Formula:C13H12O2Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:200.23 g/mol5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
CAS:5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide (CTP) is a potent inhibitor of the cytochrome P450 enzyme CYP3A4. CTP has been shown to inhibit the metabolism of midazolam, an important drug for general anesthesia and sedation, in a study investigating the interaction between CYP3A4 inhibitors and midazolam. Ketoconazole, another inhibitor of CYP3A4, inhibited the metabolism of midazolam in vitro as well. In addition, CTP was shown to be a substrate for CYP2D6 and CYP1A2 in vitro.Formula:C19H18ClN3O5SPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:435.88 g/molN-Despropyl ropinirole hydrochloride
CAS:N-Despropyl ropinirole hydrochloride is a synthetic drug product that is used as a research and development impurity standard. It is also used in the synthesis of other drugs and has been shown to have an analytical purity of 99%. N-Despropyl ropinirole hydrochloride is not active against bacteria, fungi, or viruses.Formula:C13H19ClN2OPurezza:Min. 95%Colore e forma:PowderPeso molecolare:254.75 g/mol
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