APIs per la ricerca e le impurità
I principi attivi farmaceutici (API) sono le sostanze nei farmaci responsabili dei loro effetti terapeutici. In questa sezione troverai una vasta gamma di API destinati all'uso in ricerca. Questi composti sono essenziali per lo sviluppo, il test e la validazione di nuove formulazioni farmaceutiche. Presso CymitQuimica, offriamo API di alta qualità per supportare la ricerca nella scoperta e nello sviluppo di farmaci.
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N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methylsulphinyl]ethyl]guanidine
CAS:N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methylsulphinyl]ethyl]guanidine is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. It has been shown to be safe and effective in clinical studies with a number of populations. The drug binds to the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. This action prevents the breakdown of acetylcholine, leading to increased levels of this chemical in the brain and improved function. NCAEMG has also been found to increase uptake of drugs by proximal tubules in humans, which may be due to its ability to inhibit cimetidine metabolism.Formula:C10H16N6OSPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:268.34 g/molDihydroergotamine mesylate impurity C
Dihydroergotamine mesylate impurity C is an analytical standard used for the determination of purity in Dihydroergotamine Mesylate drug products. The impurity is a metabolite that has been shown to be pharmacologically active and thus should not exceed the limit of detection.Formula:C33H37N5O6Purezza:Min. 95%Peso molecolare:599.68 g/molCefpodoxime proxetil impurity H
CAS:Cefpodoxime proxetil impurity H is an impurity of cefpodoxime proxetil, which is a prodrug that has been shown to be metabolized by esterases to the active form cefpodoxime. Cefpodoxime proxetil impurity H was found in the elution fraction when using liquid chromatography with reversed-phase as the separation method. It is thought that this impurity may arise from the use of methanol in the process of preparing cefpodoxime proxetil, although other mechanisms have not been ruled out. The mass spectrum for cefpodoxime proxetil impurity H shows peaks at m/z 812 and 682, which correspond to the parent drug and its hydrolysis product, respectively. The fragmentation pattern observed for cefpodoxime proxetil impurity H corresponds to that seen for cephalosporins.Formula:C42H54N10O18S4Purezza:Min. 95%Peso molecolare:1,115.2 g/mol1-Phenyl-1-(2-pyridinyl)methanol
CAS:1-Phenyl-1-(2-pyridinyl)methanol is an organic compound that has a reactive, functional group. It is used as a solvent in the laboratory and industry. This chemical reacts with chloride to produce 1-chloro-1-phenylmethanol. It can also be reacted with basic groups such as sodium hydroxide to produce 1-phenyl-1-(2-hydroxy pyridinium) methanol. The reaction of 1-phenyl-1-(2-pyridinyl) methanol with carbon tetrachloride produces trichlorobenzene and carbon dioxide. Impurities in this compound include inorganic acids such as hydrochloric acid and sulfuric acid, which are found at levels below 0.5%. Alcohols found in this compound include ethanolamine, which is an impurity at levels exceeding 2%.Formula:C12H11NOPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:185.22 g/mol2-EPIIvermectin B1a
2-EPIivermectin B1a is a drug product that is used as an analytical standard for the detection of impurities in API and in the synthesis of Metabolite. It is also used as a natural product for drug development. 2-EPIivermectin B1a is not intended for use as an active pharmaceutical ingredient. This product has been shown to have pharmacopoeia purity, which means it meets the specifications set by the following organizations: USP, EP, JP, BP, and CP.Purezza:Min. 95%N-Desmethyl cyamemazine maleate
CAS:Cyamemazine is an antipsychotic drug that has been used for the treatment of schizophrenia and other psychotic disorders. N-Desmethyl cyamemazine maleate, a metabolite of cyamemazine, has been shown to have neuroprotective effects in vitro.Formula:C18H19N3S·C4H4O4Purezza:Min. 95%Peso molecolare:425.5 g/molNaltrexone impurity E
CAS:Prodotto controllatoNaltrexone impurity E is an analytical standard that is used to calibrate high-performance liquid chromatography (HPLC) instruments. This substance is a natural metabolite of naltrexone, which is an opioid receptor antagonist, and has the chemical name of 4-hydroxy-3-methoxy-N-(5α,6β)-dimethyl-2-[(1R)-1-(3-methyloxetan-3-yl)piperidin-4-yl] benzeneacetamide. Naltrexone impurity E is a pharmacopoeia grade compound that can be used in the synthesis of drug products. Custom synthesis and natural or synthetic sources are available.
Formula:C24H29NO4Purezza:Min. 95%Colore e forma:PowderPeso molecolare:395.49 g/molrac N-Demethyl promethazine hydrochloride
CAS:Rac-N-Demethylpromethazine hydrochloride is a racemic mixture of promethazine. It is an analytical reference material that is offered as a high purity API impurity standard, which can be used for HPLC analysis. Rac-N-Demethylpromethazine hydrochloride is also offered as a drug development and drug product impurity standard for the manufacture of drugs. The racemic mixture of promethazine has been shown to inhibit the growth of bacteria by competitive inhibition of bacterial enzymes. Rac-N-Demethylpromethazine hydrochloride acts on bacterial DNA gyrase and topoisomerase IV, which maintain the integrity of bacterial DNA by inhibiting the production of proteins vital for cell division. Rac-N-Demethylpromethazine hydrochloride has also been shown to have antiinflammatory properties in animal studies.
Formula:C16H19ClN2SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:306.86 g/mol1-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethyl-2-(1-piperazinyl)ethoxyethanol
CAS:1-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethyl-2-(1-piperazinyl)ethoxyethanol is a synthetic drug that is used as an analytical reference standard and as an impurity standard for drug development. It is a metabolite of the benzodiazepine diazepam, which has been shown to produce significant changes in the activity of GABA receptors. This product has not been evaluated by the FDA and should be used in laboratory research only.Formula:C29H41N5O3SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:539.73 g/mol5-Aminolevulinic acid hexyl ester hydrochloride
CAS:5-Aminolevulinic acid hexyl ester hydrochloride is a cytotoxic drug that inhibits the growth of cancer cells. It is used to diagnose and treat certain cancers, including squamous cell carcinoma, skin cancer, and some types of lung cancer. 5-Aminolevulinic acid hexyl ester hydrochloride can be used in conjunction with fluorescein angiography to detect blood vessels in the skin or other tissues. This drug has also been shown to have anti-inflammatory properties that may be useful for the treatment of autoimmune diseases.Formula:C11H22NO3ClPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:251.75 g/molSemaglutide Impurity 51 (D-Thr 7)
D-Thr(7)-Semaglutide is a semaglutide impurity. The amino acid at position 7 has been replaced by the D-form of the amino acid D-threonine (D-Thr). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.Formula:C187H291N45O59Peso molecolare:4,113.64 g/molN,N',N''-Tris(4-chlorobenzylideneimino)guanidine hydrochloride
CAS:N,N',N''-Tris(4-chlorobenzylideneimino)guanidine hydrochloride is an analytical standard used to determine the purity of a drug product. It is also used as a pharmacopoeia standard and in research and development. N,N',N''-Tris(4-chlorobenzylideneimino)guanidine hydrochloride is synthesized from 4-chlorobenzaldehyde and 1,2,3-triazole. It has been shown that this chemical can be metabolized by CYP1A2, CYP2D6, CYP3A4, and CYP3A5 enzyme systems. This chemical has not been found to have any impurities.Formula:C22H17Cl3N6•(HCl)xPurezza:Min. 95%Colore e forma:White to off-white solid.Peso molecolare:471.77 g/mol2-Mercaptobenzimidazole
CAS:2-Mercaptobenzimidazole is a chemical compound that can be used for the treatment of infectious diseases. It has been shown to have antioxidative properties and inhibit the growth of bacteria. 2-Mercaptobenzimidazole also has an effect on human serum, which may be due to its ability to bind with proteins in serum and form hydrogen bonds. 2-Mercaptobenzimidazole is stable at high temperatures and has been shown as an effective antimicrobial agent against gram positive and gram negative bacteria.
Formula:C7H6N2SPurezza:Min. 99 Area-%Colore e forma:White/Off-White SolidPeso molecolare:150.19 g/molN-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride
CAS:N-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride is a metabolite that is produced by the metabolism of naphthalene. It is an impurity in the naphthalene standard, which is used as an API to assess the purity of other substances. N-[1-(R)-(+)-(2-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride has been shown to be a substrate for CYP2D6. This metabolite is also found in pharmaceuticals and other drugs.Formula:C22H22F3N•HClPurezza:Min. 95%Peso molecolare:393.87 g/mol3-Amino-4-carbamoylpyrazole hemisulfate
CAS:3-Amino-4-carbamoylpyrazole hemisulfate is a white to yellowish crystalline powder that is soluble in water and methanol. It is a condensation product of allopurinol and ethyl orthoformate with a molecular weight of 312.4. 3-Amino-4-carbamoylpyrazole hemisulfate can be used as an anti-inflammatory agent, but it has not been approved for medical use in the United States.Formula:C4H6N4OH2O4SPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:175.16 g/mol2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethanol
CAS:2- (4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethanol is a pharmaceutical intermediate that is a potent inhibitor of the enzyme acetylcholinesterase. It has been used as a photolytic probe in chromatographic experiments. 2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-piperazin-1-yl)-ethanol has been synthesized by the reaction of 4-(benzo[b]thieno[2,3d]thiazol)piperazine with ethanol. The impurities present are quantified and their concentrations are reported as percent weight/volume (% w/v). Impurities that may be found in this product include acetonitrile, orthophosphate, and linearity.Formula:C19H21N3OSPurezza:Min. 95%Colore e forma:PowderPeso molecolare:339.46 g/mol5,6-Dichloro-1,4-dihydro-2-quinazolinamine
CAS:5,6-Dichloro-1,4-dihydro-2-quinazolinamine (5,6-DCQ) is a small molecule that has been used in vitro to study postnatal development. 5,6-DCQ binds to magnesium and forms a cation complex. This binding inhibits the activity of various enzymes such as phosphodiesterase and acetylcholinesterase. 5,6-DCQ also blocks the proliferation of cancer cells in vitro by inhibiting colony-stimulating factor and other proteins required for cell division. 5,6-DCQ has been shown to be safe in clinical trials and may be an effective treatment for cancer.Formula:C8H7Cl2N3Purezza:Min. 95%Peso molecolare:216.07 g/mol
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