APIs per la ricerca e le impurità
I principi attivi farmaceutici (API) sono le sostanze nei farmaci responsabili dei loro effetti terapeutici. In questa sezione troverai una vasta gamma di API destinati all'uso in ricerca. Questi composti sono essenziali per lo sviluppo, il test e la validazione di nuove formulazioni farmaceutiche. Presso CymitQuimica, offriamo API di alta qualità per supportare la ricerca nella scoperta e nello sviluppo di farmaci.
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2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole
CAS:Rabeprazole is a proton pump inhibitor that is used to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcers. Rabeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium ATPase that is found in the parietal cells of the stomach. The main mechanism of action for rabeprazole is competitive inhibition of the proton pump, which leads to decreased gastric acid secretion. Rabeprazole can be administered orally or intravenously, with a half-life of about 2 hours. It has been shown to have an effect on human liver cytochrome P450s, but does not affect the activity of recombinant cytochrome P450 3A4 (CYP3A4). In clinical studies, rabeprazole was shown to have no adverse effects on CYP3A4 activity and may even increase it slightly.Formula:C18H21N3O2SPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:343.44 g/mol3-(3-(Trifluoromethl)phenyl-N-(R)-1-(naphthalen-1-yl)ethyl)prop-2-en-1-amine hydrochloride
CAS:3-(3-(Trifluoromethl)phenyl-N-(R)-1-(naphthalen-1-yl)ethyl)prop-2-en-1-amine is a synthetic compound, which is not found in nature. It is an API impurity and a metabolite of the drug product. It can be synthesized in high purity and with a custom synthesis. 3-(3-(Trifluoromethl)phenyl-N-(R)-1-(naphthalen-1-yl)ethyl)prop-2-en-1-amine has been found to be involved in metabolism studies and research and development, as well as analytical purposes. This compound can also serve as an impurity standard for HPLC analysis.Formula:C22H20F3N•HClPurezza:Min. 95%Colore e forma:White To Off-White SolidPeso molecolare:391.86 g/molN,N-Dimethyl-2-ene-3-(4-methylbenzoyl)-propionamide
CAS:Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is an impurity that is found in N,N-dimethyl-3-(4-methylbenzoyl)-propionamide. It is a white solid and has a melting point of 132°C. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is not soluble in water or ethanol. This compound is used as a high purity, API impurity, HPLC standard, niche, pharmacopoeia, Custom synthesis, Drug development, analytical and Synthetic drug product. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide can be metabolized by the liver to 2-[(2E)-1H-[1]benzopyran--5(6H)-ylidene]-N,N'-dimethylethane--3(2H)-carboxFormula:C13H15NO2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:217.26 g/molNaltrexone impurity E
CAS:Prodotto controllatoNaltrexone impurity E is an analytical standard that is used to calibrate high-performance liquid chromatography (HPLC) instruments. This substance is a natural metabolite of naltrexone, which is an opioid receptor antagonist, and has the chemical name of 4-hydroxy-3-methoxy-N-(5α,6β)-dimethyl-2-[(1R)-1-(3-methyloxetan-3-yl)piperidin-4-yl] benzeneacetamide. Naltrexone impurity E is a pharmacopoeia grade compound that can be used in the synthesis of drug products. Custom synthesis and natural or synthetic sources are available.
Formula:C24H29NO4Purezza:Min. 95%Colore e forma:PowderPeso molecolare:395.49 g/molAmoxicillin trihydrate impurity N
Amoxicillin trihydrate impurity N is a drug product that is an impurity in amoxicillin trihydrate. It is a natural, API impurity, which has been synthesized and tested for use as an impurity standard for HPLC analysis of amoxicillin trihydrate. The CAS number for Amoxicillin trihydrate impurity N is 592-84-1.Purezza:Min. 95%3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
CAS:3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one is a synthetic compound with research and development, impurity standard, custom synthesis, drug product, synthetic, high purity and pharmacopoeia applications. It is an impurity standard for the production of 3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)oxazolidin-2-one hydrochloride (CAS No. 513068-96-7). This compound has been synthesized in order to study the metabolism of this metabolite. Metabolism studies have indicated that 3-(3-fluoro-4-(4-morpholinyl)phenyl)-5-(hydroxymethyl)oxazolidin-2 one is rapidly metabolized to form 3-[3-[(1S)-1,2,2Formula:C14H17FN2O4Purezza:Min. 95%Peso molecolare:296.29 g/molLisdexamfetamine dimesylate impurity C
Lisdexamfetamine dimesylate impurity C is a research and development chemical with CAS No. 1207-0284-00-6 that belongs to the class of drugs. It is a custom synthesis, high purity, pharmacopoeia grade drug product that exhibits analytical properties similar to the drug product. Lisdexamfetamine dimesylate impurity C has been shown to be a metabolite of lisdexamfetamine dimesylate and is used for metabolism studies.Purezza:Min. 95%Bis{2-[(2S-trans)-Methyl 7-chloro-6,7,8-trideoxy-6-[((1-methyl-4-propyl-2-pyrrolidinyl)-carbonyl)amino]-1-thio-L-threo-a-D-galacto-o ctopyranoside]} pyrophosphate
CAS:CAS No. 37450-78-5, drug product, Custom synthesis, High purity, analytical, Metabolism studies, Natural, Drug development, pharmacopoeia, Metabolite, niche, SyntheticFormula:C36H66Cl2N4O15P2S2Purezza:Min. 95%Peso molecolare:991.91 g/molPitavastatin 3S,5R isomer calcium
CAS:Pitavastatin 3S,5R isomer Calcium Salt is a potent inhibitor of cholesterol biosynthesis. It is marketed as the hemihydrate form under the trade name Pravacol and is used in the treatment of type 2 diabetes. Pitavastatin 3S,5R isomer Calcium Salt inhibits cholesterol biosynthesis by blocking HMG-CoA reductase, which converts 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate (MVA). The active metabolite, pitavastatin, binds to the regulatory region of HMG-CoA reductase and prevents it from converting MVA to HMG-CoA. This reduces the pool of HMG-CoA available for conversion to cholesterol. The inhibition of this enzyme slows down the production of cholesterol and decreases blood levels. It has been approved for use in adults with type 2 diabetes and for lowering highFormula:(C25H24FNO4)2•CaPurezza:Min. 95%Colore e forma:White/Off-White SolidPeso molecolare:880.98 g/molN-Methyl-3-(4-naphthol)-3-(2-thienyl) propanamine hydrochloride
CAS:N-Methyl-3-(4-naphthol)-3-(2-thienyl) propanamine hydrochloride is a custom synthesis that has been shown to be a metabolite of naphthalene. It has been used as an impurity standard for N-methyl-3-(4-naphthol)-2-[(5-nitrofuran-2-yl)methyl] propanamine and in metabolism studies.Formula:C18H19NOS•HClPurezza:Min. 95%Colore e forma:PowderPeso molecolare:333.88 g/mol4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid
CAS:4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid is a white to off-white solid that is soluble in water. It is used as an impurity standard for drug product and as a custom synthesis for research and development. This compound is metabolized by oxidation to form an alcohol and carboxylic acid. The oxidation products are excreted in the urine. 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid has been used for metabolism studies with human liver microsomes.Formula:C20H38CaN2O11Purezza:Min. 95%Peso molecolare:522.6 g/mol[5-[(Dimethylamino)methyl]furan-2-yl]methanethiol, oxalate
CAS:5-[(Dimethylamino)methyl]furan-2-yl]methanethiol, oxalate is a chemical compound with the molecular formula of C4H8O2S. It is a colorless to pale yellow liquid that is soluble in water and ethanol. This product is used as an impurity standard for HPLC analysis of drugs and as a synthetic intermediate in the drug development process. 5-[(Dimethylamino)methyl]furan-2-yl]methanethiol, oxalate can be synthesized from furfuryl alcohol and methylamine under mild conditions. The purity of this product can be determined by HPLC analysis or GCMS analysis.Formula:C8H13NOS·C2H2O4Purezza:Min. 95%Peso molecolare:261.3 g/molRemdesivir nucleoside monophosphate
CAS:Remdesivir is a nucleoside monophosphate that inhibits the HIV-1 reverse transcriptase and HIV-1 protease. This drug is used to treat human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS). Remdesivir blocks the viral life cycle by preventing the production of new viruses. It also has an affinity for polymerase and phosphatase, which are enzymes necessary for viral replication. Remdesivir is uncharged, so it can be taken orally.
Remdesivir does not work against all strains of HIV, but it does inhibit some strains more than others.Formula:C12H14N5O7PPurezza:Min. 95%Colore e forma:PowderPeso molecolare:371.24 g/mol6'-Methoxy-2'-acetonaphthone
CAS:6'-Methoxy-2'-acetonaphthone is a reactive chemical that can be used as a reagent in organic synthesis. It is an electron-rich aromatic compound and its reactivity is enhanced by electron-donating groups such as -OH, -NH2, or -SH. 6'-Methoxy-2'-acetonaphthone can be used to form new carbon-carbon bonds in the presence of metal catalysts. This reaction can be done in either the presence or absence of a solvent, although the yield is better when carried out in organic solvents. Oxime derivatives are formed as oxidation products during this reaction. Acetylation may also occur, which would produce acetophenones or phenylacetones.Formula:C13H12O2Purezza:Min. 95%Colore e forma:Off-White PowderPeso molecolare:200.23 g/molN-[1-(S)-(-)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride
CAS:N-[1-(S)-(-)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride is an analytical reagent that is used in biological and pharmaceutical research. It is a potent inhibitor of parathyroid hormone release and has been shown to be a potential biomarker for hyperparathyroidism. The drug is also used as a control analysis in polymerase chain reaction experiments. When administered to animals, it has been shown to reduce the thermal expansion of cartilage tissue and increase the rate of bone resorption. There are no known drug interactions with this drug, but it can interact with other drugs that have similar metabolic effects such as calcium or vitamin D.Formula:C22H22F3N·HClPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:393.87 g/mol2-N-Butyl 3-(4-methoxy benzoyl)-benzofuran
CAS:2-N-Butyl 3-(4-methoxy benzoyl)-benzofuran is a x-ray crystal structure of an antibacterial agent that belongs to the class of β-unsaturated ketones. It has been shown to have cardiovascular activity, and is used in the treatment of depression. The compound binds to the active methylene group on the bacterial cell wall, which prevents cross linking of peptidoglycan chains. This leads to a reduction in cell wall synthesis and increased permeability of cells, which may result in death. The 2-N-butyl 3-(4-methoxy benzoyl)-benzofuran molecule also contains two phenyl groups that are able to form hydrogen bonds with each other, as well as dihedral angles that can form hydrogen bonds with water molecules. These properties contribute to its antidepressant activity.Formula:C20H20O3Purezza:Min. 95%Colore e forma:Clear LiquidPeso molecolare:308.37 g/mol3-O-Methyl L-DOPA monohydrate
CAS:Prodotto controllato3-O-Methyl L-DOPA monohydrate is a chromatographic method that is used to diagnose Parkinson's disease. The method separates the catechol-o-methyltransferase (COMT) from plasma samples, which converts dopamine to 3-O-methyl dopamine. The 3-O-methyl dopamine reacts with an electrochemical detector and overlapped peaks can be seen on the chromatogram. This analytical method can be used to detect low levels of dopamine in the blood and diagnose Parkinson's disease.Formula:C10H13NO4·H2OPurezza:Min. 95%Colore e forma:White PowderPeso molecolare:229.23 g/molBisoprolol impurity K
CAS:Bisoprolol impurity K is a drug product that is an analytical standard used for the detection and identification of bisoprolol in pharmaceutical products. It is a synthetic impurity with CAS No. 864544-37-6 that does not have any pharmacological activity. Bisoprolol impurity K is a high purity HPLC standard that can be used to develop analytical methods for the determination of bisoprolol in pharmaceutical products.
Formula:C18H29NO5Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:339.43 g/molDesfluoro atorvastatin
CAS:Desfluoro atorvastatin is a crystalline polymorph of atorvastatin that has been shown to have improved flowrate and dissolution profile compared with the conventional form. Desfluoro atorvastatin is synthesized by adding a fluorine atom to a specific position in the molecule. The synthesis procedure includes chromatographic purification and analysis of impurities, which are then eliminated by diode laser irradiation. Impurities may also be eliminated through hydrogenation or recrystallization.Formula:C33H36N2O5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:540.65 g/molCalcipotriol EP Impurity H
Calcipotriol EP Impurity H is an impurity found in calcipotriol EP. It is a metabolite of calcipotriol EP, which is the active ingredient in Dovonex. Calcipotriol EP Impurity H can be detected by HPLC with a retention time of 11.5 minutes and its purity can be determined by UV spectroscopy at 254 nm with a purity of >98%. Calcipotriol EP Impurity H can also be synthesized from natural or synthetic sources.Formula:C54H78O5Purezza:Min. 95 Area-%Colore e forma:PowderPeso molecolare:807.19 g/mol
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