Peptidi

<p>Gly-Pro-pNA • Tos is a peptide that is derived from the sequence of the human beta2 adrenergic receptor. It can be used as a research tool for studying receptor-ligand interactions and for identifying ligands for other receptors. Gly-Pro-pNA • Tos may also be used as an inhibitor of ion channels.</p>

<p>Fmoc-OSu is a synthetic amino acid that is used in the synthesis of peptides and other biomolecules. It can be synthesized by solid-phase peptide synthesis using Fmoc chemistry, which involves an acid-labile protecting group. Fmoc-OSu has been shown to inhibit cancer cell growth, although its mechanism is not known.<br>Fmoc-OSu has been shown to have anti-inflammatory effects by inhibiting the proinflammatory cytokine TNFα.<br>Fmoc-OSu has also been shown to have glycan binding properties, which may be due to its ability to bind with sialic acid residues on glycoproteins or glycolipids.</p>

<p>Azido-dPEG®8-Alcohol is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®8-Alcohol is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>CCK-Octapeptide (26-33) is a peptide that is a member of the cholecystokinin family of peptides. CCK-Octapeptide (26-33) is an activator of the CCK receptor and can be used for research purposes. This peptide has been shown to inhibit ion channels, which are proteins that regulate the flow of ions across cell membranes, and may be used as a pharmacological tool or research tool.</p>

<p>Bis-dPEG®7-NHS Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®7-NHS Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Lys-Ala-AMC is an activator of ion channels and a ligand for receptors. It is used in research as a tool to study protein interactions, receptor pharmacology, and ion channel pharmacology. Lys-Ala-AMC binds to the α-subunit of voltage gated calcium channels and can activate these channels by increasing the rate of opening. This peptide also inhibits receptor binding by competing with the natural ligand. It has been shown to be an antagonist at the NMDA receptor and can inhibit the binding of glycine to this receptor.</p>

<p>m-dPEG®24-Azide (Azido-m-dPEG®24) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-Azide (Azido-m-dPEG®24) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>MAL-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>dPEG®4 SATA (S-Acetyl-dPEG®4 NHS Ester) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. dPEG®4 SATA (S-Acetyl-dPEG®4 NHS Ester) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Fmoc-N-Lys-(dPEG®4-Biotin)-OH-(Acid) is an ion channel activator with a molecular weight of 921.5 Da. It has been shown to activate the voltage-gated potassium channels Kv1.2 and Kv1.3 in rat cortical neurons, and inhibit the activity of the voltage-gated sodium channels Nav1.6, Nav1.7, and Nav1.8 in rat dorsal root ganglia neurons. In addition, Fmoc-N-Lys-(dPEG®4-Biotin)-OH-(Acid) has been shown to activate the calcium release activated calcium channels (CRACs) in human erythrocytes and induce the release of arachidonic acid from human platelets. It is a high purity reagent for research purposes only, not for use in humans or animals for any reason other than scientific research</p>

<p>m-dPEG®4-Azide (Azido-m-dPEG®4) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®4-Azide (Azido-m-dPEG®4) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amyloid beta-Protein (Human, 25-35) is the shortest amyloid fragment that forms β-sheet fibrils, while retaining toxicity, and may also induce the aggregation of N-tau protein and N-tau peptide 1/2R. Consequently this peptide may play a role in the pathogenesis of Alzheimer's disease, a neurodegenerative disorder that affects memory and cognitive function.<br>This product is available as a trifluoroacetate salt and as a 0.5mg vial.</p>

<p>CoV-2 IgG S1 antibody binds to both SARS-CoV and SARS-CoV-2 (COVID-19) with high affinity at amino acids 318-510 in the S1 domain of the Spike protein and can be used in ELISA assays. SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies. It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics.<br>Recombinant Anti Human SARS CoV-2 IgG1 Kappa Spike S1 is a recombinant monoclonal antibody derived from HEL293 cells, which recognizes the SARS-CoV and SARS-CoV-2 Spike glycoprotein. CoV-2 IgG S1 Antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity at amino acids 318-510 (RBD, Receptor Binding Domain) in the S1 subunit of the Spike protein.  The native monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.  The ELISA Plate was coated with the target proteins at 5 µg/ml. Primary antibodies were titrated on a 3-fold serial dilution starting at 125 ng/ml,  CoV-2 IgG S1 antibody recognises SARS-CoV-2 spike protein subunit 1 (aa 1-674), or 41.6 ng/ml CoV-2 IgG S1 antibody recognised spike protein from SARS-CoV (subunit 1, aa 1-666) and SARS-CoV-2 (subunit 1, aa 1-674). Secondary antibody anti-human IgG conjugated to HRP used in the assay, at 1:4000 concentration. This product was purified through Protein A affinity and avaiable in the formulation: 1mg/ml in PBS and 0.02% Proclin 300F.</p>

<p>NHS-m-dPEG® (MW = 509) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG® (MW = 509) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Boc-Phe-Ser-Arg-AMC is a peptide that can be used as a research tool in the study of protein interactions, receptor activation and ligand binding. It is an inhibitor of ion channels and has been shown to be an antagonist of nicotinic acetylcholine receptors. This product may be used as a research tool for studying cell biology, pharmacology, and life sciences.</p>

<p>Somatostatin is a peptide hormone that is produced by the hypothalamus and inhibits the release of growth hormones, stimulates the release of insulin from the pancreas, and inhibits the release of glucagon from the pancreas. Somatostatin also has biological properties that inhibit neuronal death in combination therapy groups. It has been shown to have cell factor activity which may contribute to its antitumor activity. Somatostatin also has pro-apoptotic properties in vitro assays at physiological levels, making it an excellent target for cancer therapy.</p>

<p>Biotin-dPEG®3-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®3-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>MAL-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>t-Boc-N-Amido-dPEG®3-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-Boc-N-Amido-dPEG®3-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Suc-Gly-Pro-Leu-Gly-Pro-AMC is a high purity, monoclonal antibody that can be used as a research tool or as an inhibitor. It has been shown to inhibit ion channels and protein interactions. Suc-Gly-Pro-Leu-Gly-Pro-AMC is also known as a ligand for the receptor. It has been shown to activate the receptor and cause a change in the cell membrane permeability by increasing calcium flux, which leads to an increase in intracellular calcium levels. Suc-Gly-Pro-Leu-Gly-Pro-AMC is found in Cell Biology and Pharmacology research studies.</p>

<p>MAL-dPEG®4- NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4- NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Azido-dPEG®Sub&gt;8-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®Sub&gt;8-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Beta-casomorphin-5 (BCM-5) is a peptide that is released from the digestion of casein in milk. It is an analog of casomorphin-7, which has been shown to have opioid activity. BCM-5 has been found to inhibit the proliferation of cells and induce apoptosis by binding to P21, a protein that controls the cell cycle. BCM-5 also binds to the mu-opioid receptor and inhibits gastric acid secretion. The conformational properties of BCM-5 have been determined with analytical methods such as LC/MS/MS, NMR, and FTIR. These studies have shown that BCM-5 adopts a ß-sheet conformation when bound to mucin glycoprotein or other proteins.</p>

<p>Ser-Gln-Asn-Tyr-Pro-Ile-Val is a synthetic peptide. It has been shown to act as a competitive inhibitor of the GABA receptor, specifically in the alpha3 subunit. This inhibition has been found to be competitive with respect to GABA and benzodiazepine binding. Additionally, Ser-Gln-Asn-Tyr-Pro-Ile-Val has been shown to inhibit ion channels that are activated by extracellular potassium ions, such as KV7.1 and KV7.2 potassium channels.</p>

<p>NPY is a peptide that belongs to the family of neuropeptides. It is an endogenous regulator of appetite and energy expenditure in the central nervous system, which has been shown to act as a neurotransmitter and neuromodulator. NPY is also an activator of ion channels, such as potassium channels, sodium channels, and calcium channels. NPY has been shown to bind with high affinity to receptors in the brain, heart, lungs, kidneys, and intestines. The binding of NPY to its receptor leads to activation of protein interactions. This process can lead to changes in cell physiology or regulation of physiological functions by altering gene expression or changing the concentration of ions in the blood. NPY has also been shown as an inhibitor for many different ligands and receptors including dopamine D1 receptors and serotonin 5-HT2A/C receptors.</p>

<p>MOCAc-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-NH₂ is a protein inhibitor with a molecular weight of 1405.8 g/mol. It has a CAS number of 129857-88-6 and is available at high purity. MOCAc-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-NH₂ is used in research as an inhibitor, activator, or ligand for proteins. This product has been used in the study of ion channels, receptor binding, and cell biology.</p>

<p>MSH-Release Inhibiting Factor (MRIF) has been shown to be a potent inhibitor of the release of proinflammatory cytokines. It is derived from the acid methyl ester of mouse serum, and has been shown to inhibit the release of tumor necrosis factor-α (TNF-α) in animal studies. MRIF has also been shown to have anti-diabetic effects in mice. MRIF inhibits the production of inflammatory cytokines by blocking TNF-α at a molecular level. This protein binds to progesterone receptor and prevents it from interacting with its ligand, which is necessary for cancer cell growth. The expression system for this protein is E. coli, and it can be used as an immunosuppressant in animal studies.<br>MRIF also blocks TNF-α activity by inhibiting transcriptional activation of NFκB and AP-1, which are proteins that regulate gene expression.</p>

<p>Methionine-Enkephalin is a peptide that is derived from the amino acid methionine. It has been shown to act on ion channels and the receptor, as well as having a number of other biological effects. Methionine-Enkephalin can be used in research for pharmacology and protein interactions. This product is an antibody against methionine-enkephalin. It can be used for cell biology and immunology research, as it recognizes the peptide sequence of methionine-enkephalin. This antibody can also be used to inhibit the activity of this peptide.</p>

<p>m-dPEG®8-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®8-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>A human infecting coronavirus (viral pneumonia) called 2019 novel coronavirus, 2019-nCoV was found in the fish market at the city of Wuhan, Hubei province of China on December 2019.The 2019-nCoV shares an 87% identity to the 2 bat-derived severe acute respiratory syndrome 2018 SARS-CoV-2 located in Zhoushan of eastern China. 2019-nCoV has an analogous receptor-BD-structure to that of 2018 SARS-CoV, even though there is a.a. diversity so thus the 2019-nCoV might bind to ACE2 receptor protein (angiotensin-converting enzyme 2) in humans.While bats are probably the host of 2019-nCoV, researchers suspect that animal from the ocean sold at the seafood market was an intermediate host. RSCU analysis proposes that the 2019-nCoV is a recombinant within the viral spike glycoprotein between the bat coronavirus and an unknown coronavirus. The HEK293-derived recombinant protein contains the Coronavirus 2019-nCoV Spike Glycoprotein S1, Wuhan-Hu-1 strain, amino acids 1-681 fused to Fc tag at C-terminal having a M.W. of 76 kDa. PNTA Sepharose-Affinity Purification was used to purify the product which is avaiable as the formulation: CoV-2 S1 protein solution is supplied PBS pH 7.4.</p>

<p>PACAP27 is a peptide that is used as a research tool. PACAP27 binds to the receptor for pituitary adenylate cyclase-activating polypeptide (PACAP). The binding of PACAP27 to the receptor leads to activation of adenylyl cyclase, which increases intracellular levels of cAMP. This increase in cAMP may lead to cellular responses such as increased ion channel activity and increased protein synthesis.</p>

<p>Adrenomedullin (human) is a research tool that has been shown to activate the ligand receptor. It is a member of the vasoactive peptide family, which includes adrenalin and noradrenaline. Adrenomedullin binds to the cell surface receptors on smooth muscle cells and endothelial cells and activates ion channels. This research tool is also known as AM.</p>

<p>m-dPEG®4-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®4-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>This Neuroendocrine Regulatory Peptide-1 (human) product can be used as an endogenous suppressor of vasopressin release and is available as a 0.1mg vial. The neuroendocrine regulatory peptide-1 (NERP1) is derived from VGF and it colocalizes with vasopressin in the hypothalamus and it has been found that NERPs prevent vasopressin release from the hypothalamus. Thus NERP1 is involved in body fluid homeostasis through modulating the release of vasopressin.</p>

<p>Thiol-dPEG®8-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Thiol-dPEG®8-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amastatin is a natural protease inhibitor that has been shown to bind to the active site of serine proteases, such as trypsin and chymotrypsin. It also binds to other peptide substrates, such as angiotensin II, vasopressin and bradykinin. Amastatin is used in research as a tool for the study of protein interactions, receptor-ligand binding and ion channel activity. Amastatin is an activator of the high-affinity state of the beta-adrenergic receptor.</p>

<p>Ac-Val-Glu-Ile-Asp-H (aldehyde) is a synthetic peptide that is used as an inhibitor to study the effects of protein interactions. Ac-Val-Glu-Ile-Asp-H (aldehyde) binds to the active site of the enzyme, which prevents the enzyme from functioning and can be used as a research tool. Ac-Val-Glu-Ile-Asp-H (aldehyde) has been shown to activate some receptors and ligands, such as ion channels and antibodies.</p>

<p>Z-Gly-Phe-NH2 is a peptide that inhibits protein synthesis by binding to the ribosome. It has been shown to inhibit enzyme preparations containing peptides and proteins, such as hydrogen bond formation, phase transition temperature, uptake, and inhibitory effect. This molecule may be used in biochemical or molecular studies of protein synthesis. The uptake of Z-Gly-Phe-NH2 can be inhibited by ouabain binding. Z-Gly-Phe-NH2 also has a ca2+ response when calcium ionophores are applied to Xenopus oocytes.</p>

<p>Orexin B, also known as hypocretin-2, is a neuropeptide that is produced by a small group of neurons in the hypothalamus, a region of the brain that plays a critical role in regulating various physiological functions, including sleep, appetite, and energy balance.<br>Orexin B plays a role in promoting wakefulness and arousal and studies have shown that disruptions in the orexin system are associated with various sleep disorders, including narcolepsy and insomnia. In addition, orexin B has been shown to be involved in the regulation of appetite and energy metabolism, and is being explored as a potential target for the treatment of obesity and other metabolic disorders. Therefore, orexin B is an important neuropeptide and is an active area of research in neuroscience and medicine. This product is available as a 0.1mg vial</p>

<p>NHS-dPEG®24-Biotin is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-dPEG®24-Biotin is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Fibronectin is an extracellular matrix protein that plays a critical role in cell adhesion, migration, and differentiation. Fibronectin subunits are composed of repeating units of three types of modules: type I, type II, and type III. The active fragment of fibronectin refers to a small peptide sequence within the type III modules of fibronectin that has been shown to have potent biological activity.<br>The fibronectin active fragment, also known as the cell-binding domain or RGD domain, is a short peptide sequence consisting of the amino acid sequence Arg-Gly-Asp (RGD). This peptide sequence interacts with cell surface receptors known as integrins, which are important for mediating cell adhesion, migration, and signaling.<br>The fibronectin active fragment has been extensively studied as a research tool to investigate the mechanisms of cell adhesion and migration. It has also been used in tissue engineering applications to promote cell attachment and proliferation on synthetic biomaterials.</p>

<p>A potent vasoconstrictor, available in the hydrochloride form with disulfide bonds between Cys5-Cys10 and as a 0.5mg vial.<br>Urotensin II (UT-II) is a peptide that is found in humans and other vertebrates and is involved in biological systems such as the nervous, endocrine, cardiovascular and renal.<br>Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function. Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.<br>UT-II is widely distributed throughout the body, with highest concentrations found in the cardiovascular system, particularly in the heart and blood vessels. UT-II has been shown to have a wide range of physiological effects in humans, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin. <br>In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.</p>

<p>m-dPEG®36-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®36-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino acids 39-68 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.</p>

<p>Neuromedin S (Rat) is a peptide that is a potent inhibitor of protein interactions. It binds to the extracellular domain of the receptor and blocks its interaction with the ligand. This can be used as a research tool for studying the role of proteins in cell biology, pharmacology, or ion channels. Neuromedin S (Rat) is a high-purity peptide with CAS No. 843782-19-4 that has been shown to inhibit ligand binding to receptors in vitro and in vivo. Neuromedin S (Rat) also inhibits agonist-induced activation of ion channels at micromolar concentrations and blocks voltage-gated sodium currents at nanomolar concentrations. It has been used to study the role of neurexins in transmission at synapses between neurons by blocking their interaction with neuroligins.</p>

<p>This product is an antagonist of adrenomedulin which is a vasodilator peptide hormone and also plays a role in the stimulation of angiogenesis which can be seen as a negative to human health as it helps tumors to extend their blood supply.<br>This product is available as a 0.5mg vial.</p>

<p>Azido-dPEG®12-acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®12-acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>NHS-dPEG®4-Biotinidase Resistant Biotin is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-dPEG®4-Biotinidase Resistant Biotin is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>m-dPEG®7-Tosylate is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®7-Tosylate is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bis-dPEG®25-NHS Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®25-NHS Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Biotin-dPEG®11-Lipoamide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®11-Lipoamide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>β-Casomorphin-7 (Bovine) is an opioid peptide that belongs to the class of casomorphins. It is a fragment of the larger ß-casomorphin molecule, which is derived from the breakdown of proline-rich proteins in cow milk. β-Casomorphin-7 has been shown to have potent bronchial and renal proximal effects in rats, as well as analgesic properties. It also inhibits aminopeptidase activity in lung explants and muscle tissues, which may be due to its ability to act on opioid receptors. β-Casomorphin-7 also has been shown to inhibit growth factor production and increase the production of factor β1 in a rat model of pulmonary fibrosis. This may be due to its ability to inhibit inflammation by acting on inflammatory cells such as macrophages or neutrophils.</p>

<p>Prolactin-Releasing Peptide (Rat) is a cyclic 18-amino acid peptide that is an inhibitor of the prolactin releasing hormone. It has been shown to have a high specificity for the prolactin releasing hormone receptor and has been used as a research tool in cell biology and pharmacology. This peptide can be used to study protein interactions, which may be due to its ability to act as an activator or ligand for receptors. Prolactin-Releasing Peptide (Rat) is also able to inhibit ion channels, such as voltage-gated potassium channels and calcium channels. This peptide can also be used to generate antibodies against the prolactin releasing hormone receptor.</p>

<p>Bis-dPEG®7-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®7-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Corticotropin Releasing Factor (CRF) is a peptide hormone involved in the regulation of the neuroendocrine system, the hypothalamic-pituitary-adrenal (HPA) axis. The hypothalamus releases CRF during stress and in turn CRF stimulates the production of stress hormones such as glucocorticoids and adrenocorticotropin (ACTH). A negative feedback loop is created as glucocorticoids then prevents further endocrine activity exhibited by the pituitary gland and hypothalamus. Interestingly in patients with depression, it has been found that the hypothalamic-pituitary adrenal axis is over stimulated thus increased production of CRF occurs resulting in depression symptoms. Furthermore studies have shown the expression of CRF receptors in glial cells and T-cells and elevated levels of CRF and glucocorticoids prevent T-cell proliferation. During stress cytokines can also stimulate the secretion of CRF. However CRF can also regulate these cytokines. CRF has the potential to be used in the research into depression treatments. <br>This product is available as a 0.1mg vial.</p>

<p>Margatoxin is a research tool that has been shown to activate the nicotinic acetylcholine receptor. It binds to the ligand-binding site of the receptor and blocks ion channel activity. Margatoxin is a small molecule with high purity that can be used as a tool to study protein interactions and biological functions. This compound is also an inhibitor of peptide binding, which can be used in pharmacology studies.</p>

<p>A human infecting coronavirus (viral pneumonia) called 2019 novel coronavirus, 2019-nCoV was found in the fish market at the city of Wuhan, Hubei province of China on December 2019. The 2019-nCoV shares an 87% identity to the 2 bat-derived severe acute respiratory syndrome 2018 SARS-CoV-2 located in Zhoushan of eastern China. 2019-nCoV has an analogous receptor-BD-structure to that of 2018 SARS-CoV, even though there is a.a. diversity so thus the 2019-nCoV might bind to ACE2 receptor protein (angiotensin-converting enzyme 2)  in humans. While bats are possibly the host of 2019-nCoV, researchers suspect that animal from the ocean sold at the seafood market was an intermediate host. RSCU analysis proposes that the 2019-nCoV is a recombinant within the viral spike glycoprotein between the bat coronavirus and an unknown coronavirus. The E. coli derived recombinant protein contains the Coronavirus 2019 C-terminal region 127 a.a. from the Nucleocapsid protein and fused to GST-6xHis tag at N-terminal and having a M.W. of 39.4 kDa. It has been purified using PNTA Sepharose-Affinity Purification. The CoV-2 Nucleocapsid protein solution is supplied in 50mM Tris-HCl pH 8, 1M Urea, and 50% Glycerol.</p>

<p>Beta-Neo-Endorphin is an opioid peptide which binds with high affinity to μ, δ and κ-receptors and has been found to be involved in the modulation of pain, epidermal nerve fiber regulation and skin homeostasis. It is further demonstrated the ability to in human keratinocytes, stimulate wound healing. Beta-neoendorphin is derived from prodynorphin when it is proteolytically cleaved.<br>This product is available as a 0.5mg vials and is sourced from Porcine.</p>

<p>GIP is a peptide that is produced by the cells of the small intestine. GIP has been shown to be an inhibitor of insulin secretion and, in turn, may help regulate glucose levels. It also regulates growth hormone release in response to food intake. GIP acts as a ligand for the receptor known as the “gastric inhibitory polypeptide receptor” which is found on pancreatic beta cells and duodenal L-cells. This protein has been shown to activate ion channels and regulate their activity. The GIP receptor is also expressed on certain types of cancer cells, including breast cancer and colorectal cancer. Antibodies have been generated against this protein for use in research tools such as Western blotting or immunohistochemistry.</p>

<p>IL-1α is a cytokine protein that has been shown to be involved in the immune system. IL-1α is an activator of the receptor and is also a ligand for it. The protein has been shown to activate ion channels, which are proteins that allow ions to pass through either by diffusion or by facilitated transport. This activation causes cells to produce more hydrogen ions, which leads to an increase in the acidity of the cell. IL-1α has also been shown to inhibit cell proliferation and induce apoptosis.</p>

<p>Suc-Ala-Ala-Ala-pNA is a peptide that binds to the acetylcholine receptor and activates it. This peptide has been shown to have potential as a research tool for studying the pharmacology of acetylcholine receptors in vitro. It has also been used as an inhibitor of neuronal ion channels, such as potassium channels, that are involved in the transmission of nerve impulses. Suc-Ala-Ala-Ala-pNA is not suitable for use in humans because it would be broken down by proteases before it could reach its target, but this peptide has applications in cell biology and neuroscience.</p>

<p>MAL-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Lys-AMC is a potent and selective activator of the TRPM2 ion channel. It binds to the extracellular loop of the TRPM2 receptor, which is located in the membrane of cells. Lys-AMC activates TRPM2 by binding to its extracellular loop and opening it, allowing calcium ions to enter the cell. This leads to a change in cellular activity, such as increased production of reactive oxygen species or altered gene expression. Lys-AMC can be used for research purposes or as an inhibitor of TRPM2 channels.br&gt;br&gt;<br>Lys-AMC is a high purity product with a CAS number of 92605-76-0. It has been shown to bind specifically and selectively to TRPM2 receptors without any cross reactivity with other proteins, making it an ideal tool for research purposes. Lys-AMC can be used as an antibody or cell biology reagent that can inhibit TRPM2 channels.br&gt;br&gt;</p>

<p>Luteinizing hormone-releasing hormone (LH-RH), also known as Gonadotropin-Releasing Hormone (GnRH), stimulates the pituitary gland’s production and secretion of luteinizing hormone and follicle-stimulating hormone. LHRH is a decapeptide and is itself secreted by the hypothalamus. It is crucial for human reproduction and is heavily involved in the regulation of ovulation, sexual development and the onset of puberty.<br>When secreted, GNRH binds to the G-protein coupled receptor, gonadotropin-releasing hormone receptor (GNRHR) located on pituitary gonadotrophic cells in the anterior pituitary.<br>Medically, the understanding of GnRH is paramount, due to its involvement in the pathogensis of central hypogonadism. Any obstructions to its function in the reproductive system can result in the development of human pathologically conditions. It is important to note that analogs of GnRH can be used in pharmacology, in the treatment of gynaecological diseases, through blocking the secretion of estrogen secretion from the ovary. Additional GNRH analogs can be used to treat ovarian cancer, hormone-dependent cancers, endometriosis and modality in infertility. Therefore this product is a useful research tool.</p>

<p>Ac-Ile-Glu-Thr-Asp-H (aldehyde) is a peptide fragment of the human calcitonin gene. It is a research tool used in immunology and cell biology. Ac-Ile-Glu-Thr-Asp-H (aldehyde) binds to different types of ion channels, including ligand gated ion channels, voltage gated ion channels, and receptor activated ion channels. Ac-Ile-Glu-Thr-Asp-H (aldehyde) can also bind to membrane receptors such as the muscarinic acetylcholine receptor and the alpha adrenergic receptor. Acetylcholine is a neurotransmitter that activates the muscarinic acetylcholine receptor, which leads to an increase in intracellular levels of cyclic AMP. Alpha adrenergic receptors are located on the surface of blood vessels and activate vasoconstriction by inhibiting adenylyl cyclase activity.</p>

<p>Amino-dPEG®36-t-Butyl Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®36-t-Butyl Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Ac-Arg-OMe • HCl is a labile peptide that has been shown to be homologous to the human Arg-Gly-Asp (RGD) sequence. Ac-Arg-OMe • HCl is activated by trypsin and trypsin-like proteases, but inactivated by hemolytic activity and conformation. Ac-Arg-OMe • HCl is an enzyme substrate for peptidases such as trypsin and trypsin like proteases. It has been shown to be a molecule that interacts with various proteins, including hemoglobin.</p>

<p>Ac-Phe-OEt is a covalently conjugated bifunctional peptide that has been synthesized by linking the amino acid phenylalanine to the amino acid ethyl ester of oleic acid. Ac-Phe-OEt exhibits a high affinity for bacterial serine proteases (Km=0.1 μM) and lysine residues (Ki=4 μM). This peptide also binds to immobilized cytochalasin, which prevents the formation of amyloid fibrils. Ac-Phe-OEt can be used in enzyme catalysis as an inhibitor or competitive inhibitor, as well as being immobilized on surfaces. The kinetic data suggests that Ac-Phe-OEt competes with lysine residues for binding to bacterial serine proteases and inhibits their activity.</p>

<p>Biotin-dPEG®7-NH2 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®7-NH2 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>GRP (Human) is a protein that belongs to the group of peptides. It is an activator of G-protein coupled receptors. GRP (Human) has been shown to be a ligand for the receptor GPVI, which is involved in the activation of platelets and megakaryocytes. GRP (Human) can also inhibit ion channels, such as voltage-gated sodium channels or calcium channels. This protein is used in research for studying cell biology and pharmacology. GRP (Human) is purified at high purity by a process involving chromatography and gel filtration.</p>

<p>Deoxyribonuclease I Bovine is an enzyme extracted from pancreas, thymus, or bovine tissue culture. It may be used to digest proteins in order to remove damaged linkages and produce a soluble protein-free extract. Deoxyribonuclease I Bovine can also be used for the removal of DNA from cells, tissues, and organs for biochemical methods such as biochemical assays, immunoassays, and nucleic acid amplification.</p>

<p>Fmoc-N-Amido-dPEG®8-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Fmoc-N-Amido-dPEG®8-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>[D-Ala2,D-Leu5]-Enkephalin is a peptide that has been shown to activate certain opioid receptors and inhibit ion channels. It is also known to be an antagonist of the D2 receptor. This compound has a high purity and can be used as a research tool for studies in cell biology, pharmacology, and life sciences.</p>

<p>Amino-dPEG®8-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, amino-dPEG®8-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Bradykinin is a peptide hormone that can be formed from the breakdown of kininogen. It works by binding to specific receptors found on the surface of cells and activating a G-protein coupled receptor. Bradykinin stimulates the secretion of gastric acid, increases the permeability of capillaries in the lungs, and causes contraction of smooth muscle in many organs. Bradykinin also has an important role in regulating blood pressure and heart rate. Des-Arg9-[Leu8]-Bradykinin (D-BK) is a potent inhibitor of this activity and is used as an antihypertensive agent. D-BK prevents the activation of G-proteins by binding to receptors with high affinity and specificity. When it binds to its receptor, it inhibits cyclic AMP production, which leads to decreased cell activity and vasodilation. This inhibition reduces blood pressure by reducing cardiac output and increasing systemic vascular resistance.</p>

<p>dPEG®48-Biotin Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. dPEG®48-Biotin Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Azido-dPEG®23-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®23-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Z-Gly-Leu is a monoclonal antibody that inhibits the enzyme protease. It binds to the active site of the enzyme and prevents it from cleaving peptides into smaller fragments. The antibody also binds to casein, a protein found in milk, and soybean trypsin inhibitor. This prevents these enzymes from degrading other proteins in the body. The antibody is reactive at phase transition temperatures and has been shown to be effective on wild-type mice.</p>

<p>Somatostatin is a peptide hormone that is widely expressed throughout the body; in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. It has been found to inhibit pituitary growth hormone release as well as endocrine, pancreatic and GI secretions. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma. This product contains disulfide bonds between Cys3-Cys14.</p>

<p>Bis-dPEG®7-Acid is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®7-Acid is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Ac-Tyr-NH2 is a rotameric peptide that has been shown to inhibit the growth of bacteria. It is a neutral compound and does not have any detectable effect on human serum. Ac-Tyr-NH2 has been shown to react with tryptophan, which may be due to its acid hydrolysis. This peptide also has an active role in the production of reaction products and the formation of model proteins. Ac-Tyr-NH2 has been shown to have an optical property of fluorescence, which can be used for skin reactions or uv absorption.</p>

<p>Bis-dPEG®5-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®5-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>MAL-dPEG®12-Tris (dPEG®12-Tris (m-dPEG®11)3)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®12-Tris (dPEG®12-Tris (m-dPEG®11)3)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Anti-Secretin (Porcine) Serum is a high purity, serum-based protein that is used in research and cell biology experiments. It contains a variety of proteins including antibodies, activators, inhibitors, and peptides. Anti-Secretin (Porcine) Serum is used to study the function of ions channels and ligands. This product also has a wide range of applications in pharmacology and cell biology. The CAS number for this product is 109376-05-8.</p>

<p>Amyloid β-Protein (Human, 1-38) is a peptide that is a major constituent of the amyloid plaques found in the brains of people with Alzheimer's disease. It has been shown to inhibit ion channels and ligand-activated ion channels. The receptor for this protein is unknown, but it may be involved in cell signaling or neurotransmitter release. Amyloid β-Protein (Human, 1-38) can be used as a research tool to study proteins and their interactions with other proteins, as well as to study how these interactions affect the function of cells. It can also be used to study how antibody molecules bind to specific proteins and how these antibodies interact with other molecules.</p>

<p>Azido-dPEG®11-amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®11-amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

[Pyr11]-Amyloid β-Protein (Human,11-40) is a peptide fragment of amyloid beta protein that is found in the brain. It has been shown to bind to receptors and activate ion channels. The binding of amyloid beta to these receptors may play a role in Alzheimer's disease and other neurological disorders. This product is for research purposes only, not for use in diagnostic procedures.

<p>This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.</p>

<p>m-dPEG®12-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Tuftsin is a ligand with the ability to activate specific receptors. It is also known as Activator, and is a reagent that can be used in research for cell biology and pharmacology. Tuftsin has been shown to bind to ion channels and act as an inhibitor of these channels. This activity leads to the inhibition of calcium influx into cells, which may be important for regulating cellular processes such as apoptosis, cytoskeletal rearrangement, or protein synthesis. It may also play a role in immune response pathways.</p>

<p>dPEG®12-diol is a synthetic compound that has high purity, an excellent shelf life, and can be used as a research tool or as a pharmaceutical. The synthesis of dPEG®12-diol involves the coupling of two molecules of 12-deoxyphosphatidylcholine with 1,2-di(2′-ethylhexyl)-glycerol (DEHG). This process results in the formation of dPEG®12-diol. dPEG®12-diol is a potent inhibitor of ion channels and has been shown to affect cellular metabolism. It has also been shown to have anti-inflammatory effects in vitro and in vivo.</p>

<p>DNP-dPEG®12-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DNP-dPEG®12-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Neuromedin U is a peptide that is found in the brain and has been shown to have a variety of effects on the body. It can be used as an activator or inhibitor of ion channels and has been shown to inhibit ligand-gated ion channels. Neuromedin U can also act as a ligand for G-protein coupled receptors, which are involved in many physiological processes. The high purity of this product makes it suitable for use in research tools such as antibodies.</p>

<p>SARS-CoV is a coronavirus that causes SARS. This protein is the nucleocapsid protein of SARS-CoV and is encoded by the ORF2 gene. This protein is a component of the viral nucleocapsid, which contains the viral genomic RNA. Antibodies against this protein are used in serological tests to detect recent infection with SARS-CoV or SARS-CoV/SARS-CoV-2. COVID-19 (also known as 3C8) is an antibody that specifically binds to this protein and can be used as a diagnostic marker for SARS.</p>

<p>MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH₂ is a peptide that is used as a research tool in cell biology. It can be used to study the interactions between proteins, receptors and ion channels. MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH₂ has been shown to activate the G protein receptor, which is involved in the transmission of signals by cells. The peptide is also an inhibitor for ligand binding to the receptor.</p>

<p>Amyloid beta-protein (Aβ) is a peptide that is believed to play an important role in the development of Alzheimer's disease. Aβ is produced by proteolytic cleavage from the amyloid precursor protein and is released into the extracellular space, where it can interact with other cells. The protein has been shown to activate ion channels and inhibit cell proliferation. It also binds to receptors on cells, which leads to downstream effects such as inhibition of ligand binding and activation of G-protein coupled receptor signaling pathways.</p>

<p>NHS-dPEG®4 Biotin is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-dPEG®4 Biotin is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Glu-Glu is a mouse monoclonal antibody (IgG2a) that inhibits the activity of human leukocyte elastase. Glu-Glu has been shown to inhibit the production of inflammatory cytokines, such as IL-8 and TNF-α, in human serum obtained from patients with chronic cough. It also blocks the formation of disulfide bonds in peptides and proteins, which are important for their function. Glu-Glu has been used to study pathogenic mechanisms of chronic obstructive pulmonary disease and metabolic disorders, as well as its effects on polymerase chain reactions and enzyme activities in vitro.</p>

<p>Cbz-N-Amido-dPEG®6-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Cbz-N-Amido-dPEG®6-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino acids 1-44 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.</p>

<p>PHM-27 is a peptide that is used as a research tool in the fields of cell biology, pharmacology and immunology. It is also used to study protein interactions and receptor/ligand interactions.</p>

<p>Physalaemin is a peptide that has been found to be an activator of the G-protein coupled receptor. Physalaemin has been shown to inhibit ion channels, such as potassium channels and calcium channels. Physalaemin may also inhibit the activity of certain ligands, such as bradykinin and substance P. This peptide can also act as a research tool for pharmacology and cell biology.</p>

<p>t-boc-N-Amido-dPEG®36-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-boc-N-Amido-dPEG®36-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Lipoamido-dPEG®4-TFP Ester is a PEG molecule conjugated with a lipid moiety. Lipoamido-dPEG®4-TFP Ester, conjugated to this lipid constituent, is very important especially in drug delivery and vaccine development as it helps improve the stability and circulation time of lipid nanoparticles (LNPs) and liposomes.</p>

<p>Suc(OMe)-Ala-Ala-Pro-Val-AMC is an activator ligand that binds to the receptor. It is a research tool and is used in cell biology, antibody production, ion channels and pharmacology. This compound can be used as an inhibitor for protein interactions. Suc(OMe)-Ala-Ala-Pro-Val-AMC has high purity and is a peptide. The CAS number of this compound is 72252-90-5.</p>

<p>Azido-dPEG® 8-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG® 8-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino-dPEG®4-t-boc-hydrazide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-t-boc-hydrazide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Z-Gly-Pro-Arg-AMC is a synthetic peptide that can inhibit the activity of various enzymes. It has been shown to be an inhibitor of protein interactions, activator of ligand, and receptor. This peptide is used as a research tool in cell biology and pharmacology studies. Z-Gly-Pro-Arg-AMC is also used in high purity applications (e.g., ion channels) and antibody production.</p>

<p>[D-Ala2,Met5]-Enkephalin is a peptide. It is a potent and specific activator of opioid receptors. It has been used to study the effects of opioid peptides on ion channels and receptor interactions, as well as for research into protein interactions and pharmacology.</p>

<p>TFP-dPEG®4-( m-dPEG®24)3-Ester is a research tool that can be used as an activator or ligand for cell biology, antibody characterization, ion channels, and protein interactions. This product may also be used in pharmacology and peptide synthesis. TFP-dPEG®4-( m-dPEG®24)3-Ester is also an inhibitor of CAS No. 1108750-59-9.</p>

<p>Amino-dPEG®2-t-butyl ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®2-t-butyl ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Cbz-N-Amido-dPEG®12-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Cbz-N-Amido-dPEG®12-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Morphine tolerance peptide is a cyclic peptide analog of morphine. It has been shown to have an affinity for the kappa-opioid receptor that is similar to that of morphine, but it has a higher potency and a longer duration of action. The molecular modeling study indicates that the analog interacts with the receptor in a similar manner as morphine and exhibits high selectivity for this receptor. The analog also shares many of the same features as morphine in terms of depressant effect and locomotor activity, but does not produce any kind of withdrawal syndrome.</p>

<p>Azido-dPEG®7-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®7-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>[Met(O)12]-ANP (Human, 1-28) is a peptide that activates the guanylate cyclase. It has been shown to bind to the receptor for ANP, which is present in many cell types. The binding of [Met(O)12]-ANP (Human, 1-28) to its receptor leads to an increase in intracellular cGMP levels and consequently an increase in intracellular cAMP levels. This product is a research tool for protein interactions and can be used as an inhibitor or activator. The purity of this product is &gt;98%.</p>