LSN 3154567
CAS: 1698878-14-6
Rif. 3D-BL165041
| 5mg | 111,00 € | ||
| 10mg | 157,00 € | ||
| 25mg | 297,00 € | ||
| 50mg | 467,00 € | ||
| 100mg | 712,00 € |
Informazioni sul prodotto
- 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
Nicotinamide phosphoribosyl transferase (NAMPT) competitive inhibitor with IC50 = 3.1 nM. A major consequence of NAMPT inhibition is the attenuation of glycolysis at the GADPH step because this enzyme requires NAD+ for activity. The compound exhibits broad spectrum anti-cancer activity and significant tumor regression was observed in vitro. Although retinal and haematological toxicity has been associated with NAMPT inhibitors, LSN 3154567 does not lead to retinopathy in rats and can be mitigated with co-administration of nicotinic acid.
Proprietà chimiche
Richiesta tecnica su: 3D-BL165041 LSN 3154567
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