PD 123,319 di(trifluoroacetate) salt hydrate
CAS: 136676-91-0
Rif. 3D-LFA67691
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Informazioni sul prodotto
- PD 123,319 hydrate di(trifluoroacetate) salt
PD 123,319 di(trifluoroacetate) salt hydrate is a selective inhibitor of the neurokinin-1 receptor. In animal studies, PD 123,319 di(trifluoroacetate) salt hydrate has been shown to reduce hyperactivity and produce an antinociceptive effect by inhibiting the release of substance P from nerve terminals. The compound also has a protective effect on neurons and tissues in animals with traumatic brain injury. It also inhibits spontaneous pain behaviour in rats with cancer or experimental arthritis and reduces angiotensin-II induced hypertension in rats.
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PD 123,319 di(trifluoroacetate) salt hydrate binds to the neurokinin-1 receptor (NK1R). The NK1R is a G protein coupled receptor that is expressed on nociceptive neurons in the spinal cord and brainstem. NK1R activation induces the release of substance P from nerve terminals. Substance
Proprietà chimiche
Richiesta tecnica su: 3D-LFA67691 PD 123,319 di(trifluoroacetate) salt hydrate
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