Diethyl p-Toluenesulfonyloxymethylphosphonate

CAS: 31618-90-3

Rif. TR-D445260

Informazioni sul prodotto

• Nome: Diethyl p-Toluenesulfonyloxymethylphosphonate
• Sinonimi: diethoxyphosphorylmethyl 4-methylbenzenesulfonate, (Diethoxyphosphoryl)Methyl 4-Methylbenzenesulfonate, 4-Methylbenzenesulfonic acid (diethoxyphosphoryl)methyl ester, Desmp, Detp, Diethoxyphosphorylmethyl tosylate, Diethyl P-Toluenesulfonyl Oxymethyl Phosphonate, Diethyl P-Tosyloxymethylphosphonate, Diethyl P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]phosphonate, Diethyl [[(P-Toluenesulfonyl)Oxy]Methyl]Phosphonate, Diethyl [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonate, Diethyl p-toluene sulfonyl oxymethyl phosphonate, Diethyl p-toluene sulfonyloxy methyl phosphonate, Diethyl p-toluenesulfonyloxymethylphosphonate, PMPA monohydrate, Phosphonic acid, (hydroxymethyl)-, diethyl ester, p-toluenesulfonate, Phosphonic acid, P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester, Phosphonic acid, [[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester, Tosyloxymethyl Diethyl Phosphonate, [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonic Acid Diethyl Ester

Descrizione

Applications Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 322.31
• Formula: C₁₂H₁₉O₆PS
• Colore/Forma: Neat
• InChI: InChI=1S/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3
• InChI key: InChIKey=UOEFFQWLRUBDME-UHFFFAOYSA-N
• SMILES: CCOP(=O)(COS(=O)(=O)c1ccc(C)cc1)OCC