CymitQuimica ha oltre 25 partner, tra i quali spicca il fornitore TargetMol

<p>Epoxymicheliolide (1β,10β-Epoxymicheliolide) is a novel guaiane-type sesquiterpene lactone isolated from Inula helenium L.</p>

<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>

<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>

<p>Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.</p>

<p>PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor.</p>

<p>6”-O-Apiosyl-5-O-Methylvisammioside is one component of the traditional Chinese medicine Kang-Jing which has the functions of promoting blood circulation and</p>

<p>TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).</p>

<p>Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).</p>

<p>Fenebrutinib (GDC-0853) is an oral BTK inhibitor that blocks B-cell activation and growth in cancers overexpressing BTK.</p>

<p>ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2,</p>

<p>Calcipotriol monohydrate, a Vitamin D3 analog, binds well to the vitamin D receptor, used in psoriasis research.</p>

<p>Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.</p>

Fludroxycortide, a synthetic topical steroid, serves as an anti-inflammatory treatment for skin irritations.

<p>7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.</p>

<p>Alisol F is a natural product from Alisma plantago-aquatica Linn and has many activities.</p>

<p>Alisol G (25-Anhydroalisol A) is isolated from Rhizoma Alismatis and exhibits hCE2 inhibitory effects.</p>

<p>CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).</p>

<p>(Z)-2-decenoic acid: short-chain fatty acid from Pseudomonas aeruginosa, disrupts and inhibits biofilms of various bacteria.</p>

<p>BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).</p>

<p>PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).</p>

<p>Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.</p>

<p>FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).</p>

FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).

Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956)

Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.

<p>Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.</p>

<p>Dihomo-γ-linolenic acid (DGLA) has antitumor and antiproliferative effects and inhibits the growth of xenograft tumor cells.</p>

<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>

<p>Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity.</p>

<p>Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.</p>

<p>MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).</p>

Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).

<p>Melittoside: phenolic glycoside with antioxidant, anti-inflammatory, antifungal properties; researched for cancer, diabetes, heart disease treatment.</p>

<p>Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).</p>

<p>Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.</p>

Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.

<p>D-(+)-Neopterin (D-(+)-Neopterin) is produced by human monocytes/macrophages upon stimulation with the cytokine interferon-γ.</p>

<p>27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.</p>

<p>LysoPC(14:0/0:0) is a lysophospholipid (LyP) and mono-glycerophospholipid.</p>

<p>Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.</p>

<p>Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T</p>

<p>Pralsetinib (BLU-667) is a potent RET inhibitor targeting WT, V804L/M, M918T, and fusion mutants (IC50: 0.3-0.4 nM).</p>

Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.

Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).

<p>Avosentan（Ro 67-0565; SPP-301） is a potent endothelin receptor (ETA) antagonist.Cost-effective and quality-assured.</p>

<p>RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.</p>

<p>Hydroxyphenyllactic acid is an antifungal metabolite, fungi such as Lactobacillus sp. SK007.</p>

<p>Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in the brain.</p>

Spaglumic acid acetate (Isospaglumic acid acetate) is a neuropeptide found in millimolar concentrations in brain.

<p>MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM).</p>

<p>Chrysin-7-O-glucuronide (Chrysin 7-O-beta-D-glucopyranuronoside) is a natural product, with antioxidant activity</p>

<p>Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.</p>

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

<p>ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.</p>

<p>Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous</p>

Grapiprant (AAT-007) is a selective EP4 receptor antagonist.

<p>AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).</p>

<p>Coumestrol in soybeans inhibits ES2 cell growth (IC50: 50 μM) and combats neurological issues, cancer, and autoimmunity.</p>

<p>N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).</p>

<p>N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50:</p>

Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.

<p>Fagomine (D-Fagomine) is a glycosidase inhibitor, an analog of 1-deoxynojirimycin (DNJ), with hypoglycemic activity.</p>

<p>Exalamide (2-(Hexyloxy)benzamide) is an aromatic amide with antifungal activity used in the study of dermatophytes.</p>

<p>Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).</p>

<p>Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.</p>

<p>Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer.</p>

<p>Metixene HCl hydrate is a potential anticholinergic for Parkinson's with IC50 of 55 nM and Ki of 15 nM against muscarine receptors.</p>

<p>CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).</p>

<p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>

<p>Vernakalant (RSD-1235) is a mixed ion channel blocker.</p>

<p>Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.</p>

Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).

<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>

<p>GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).</p>

Sphingomyelin is a natural sphingolipid that existed in animal cell membranes. It implicates the regulation of transmembrane signaling.

NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).

<p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>

<p>Tandospirone (SM-3997) is a 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity used in the study of central nervous system disorders.</p>

<p>Ingenol-5,20-acetonide-3-O-angelate (Ingenol 5,20-acetonide 3-angelate) is a natural product.</p>

<p>R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.</p>

<p>Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.</p>

<p>'ARRY 520 hydrochloride: a KSP inhibitor causing apoptosis and strong anti-proliferative effects.'</p>

BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).

<p>Advanced glycation end products are the outcome of non-enzymatic glycation reactions involving biomolecules such as proteins, lipids, reducing sugars.</p>

<p>Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, transporting oxygen from the lung to tissue.</p>

<p>Submandibular mucin is a high molecular weight glycoprotein that serves as a substrate for viral neuraminidase enzymes.</p>

<p>PorcineFactor Xa is obtained by activating purified Porcine Factor X using Russells' Viper Venom, after which the venom is removed.</p>

<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>

<p>Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.</p>

<p>O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.</p>

Osteocalcin, bovine is a vitamin K-dependent bone-specific protein, also known as bone gamma-carboxyglutamate protein (BGLAP). It is a small (49 amino acids) non-collagenous hormone.

<p>α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerophosphate dehydrogenase (GDH) and triosephosphate isomerase (TIM). This compound is employed to measure transketolase (TK) activity in erythrocyte hemolysates, which helps in assessing vitamin B deficiency.</p>

<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>

SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.

<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>

<p>Sortase A, S. aureus (SrtA) is found in many Gram-positive bacteria and facilitates the recruitment of cell surface proteins. It plays a crucial role in the attachment of various molecules on the cell surface.</p>

AMK318 (Immobilized cephalexin acylase) is a biocatalyst and a critical enzyme in novel biocatalyst technology. Enzyme engineering focuses on improving enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions (such as low or high pH). By incorporating stimulus responsiveness into these enzyme modifications, dynamic control of activity becomes feasible.

CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.

Aspartate Aminotransferase, Human is a biocatalyst and serves as a pivotal enzyme in new biotechnology. Enzyme engineering aims to improve the reaction kinetics, substrate specificity, and activity under extreme conditions (such as low or high pH). By introducing stimuli-responsive modifications to these enzymes, the dynamic regulation of activity can also be achieved.

<p>N-Acetylgalactosaminyltransferase 4 (GALNT4) is a glycosyltransferase capable of inhibiting the activation of ASK1. It functions by directly binding to ASK1, preventing N-terminal dimerization and subsequent phosphorylation. This interaction leads to significant inactivation of downstream JNK/p38 and NF-κB signaling, thereby improving the prognosis of liver surgery.</p>

<p>ST6Sialyltransferase5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers sialic acid to N-acetylgalactosamine (GalNAc) residues. It may serve as a biomarker in cervical screening samples.</p>

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

HumanFactor VIIa is a vitamin K-dependent serine protease involved in the blood coagulation process. It has the ability to activate coagulation factor X, which in turn converts prothrombin into thrombin, leading to the transformation of fibrinogen into fibrin and resulting in the formation of blood clots. HumanFactor VIIa holds potential for improving hemophilia.

Recombinant Trypsin is a serine protease that hydrolyzes proteins at the carboxyl side of lysine or arginine.

dsDNase is a highly specific endonuclease for double-stranded DNA (dsDNA) that can rapidly and efficiently eliminate contaminant DNA from PCR master mixes.

<p>Manganese chloride tetrahydrate) is a high-purity manganese salt that can serve as a cofactor for enzyme reactions and provide essential trace elements</p>

<p>Heptanoic acid sodium is the sodium salt of Heptanoate. can inhibit the osteoporosis and gluconeogenesis of Heptanoate.</p>

<p>2-Amino-2-methyl-1,3-propanediol is an activator of 2-oxoaldehyde dehydrogenase a solid-solid phase change material (PCM) and biological buffer.</p>