TLC expands its product porfolio ( and CymitQuimica too)
This year TLC Pharmaceutical Standards Ltd has obtained the license for the production of controlled substances and with this, it has increased its product range. One of the most remarkable features of the TLC catalog is the wide variety of products, which covers all the needs to carry out any organic synthesis: research, development of organic processes, expansion of processes and/or custom manufacturing (from grams to several kilograms).
Within its extensive catalog, we can classify TLC products into four large groups, with thousands of references each:
-API Impurities (Active Pharmaceutical Ingredient Impurities): They are very useful for detecting the presence of different impurities in drugs. Impurities are chemical species that are not wanted in the final product, and that cause a lower yield in the synthesis. In many degradation reactions we obtain various impurities and thanks to the API impurities we can determine them. Furthermore, in the crystalline phases of the synthesis process, we use the API Impurities to detect the exact impurity of our compound.
Most TLC references offer both the natural product and its respective variants/modifications. E.g. in the case of API impurities, we will also find their respective API in the catalog (Figure 1).
- Amino acid/polypeptide drug standards: They are the basis for the detection and quantification of amino acids in samples. Polypeptide standards are used, for example, to investigate genetic processes and/or to study metabolic pathways.
- Analogs marked with stable isotopes: this part of the TLC portfolio is more oriented to specific research needs. For example, this analysis of endogenous compounds, which uses these stable isotopes (SIL) as a calibration standard for the study of bile acids (Zheng et al., 2016): The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay - PubMed (nih.gov)
- Metabolites: In general, any substance produced during metabolism is comprised in this category. However, in pharmaceutical chemistry it usually refers to the product that remains after the body's (metabolic) breakdown of a drug (often a hydrolysis).
Finally, and in relation to quality, TLC has high standards for its certification of reference standards through complete chemical analysis, the isolation and characterization of impurities and their degradation products.
TLC is accredited by ISO 9001:2015, ISO 14001:2015 and OHSAS 18001:207
