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Life Science Product News: Inhibitor Cocktails and Cell Cycle Related Kits

Life Science Product News: Inhibitor Cocktails and Cell Cycle Related Kits

5 Oct 2022

Reagent Kits


The reliability of a kit is an important factor to ensure the success of many experiments. Our brand Targetmol can provide several prepared kits for molecular biology, which have many advantages such as high sensitivity, good stability, strong anti-interference ability, and these properties can ensure the smooth progress of this experiments.


As an example, it is easy for the proteins to be degraded or dephosphorylated during in vitro extraction procedure, which could cause an inaccurate result of protein expression detection. Therefore, adding the protease inhibitors or phosphatase inhibitors kits into the extracts would be an effective method to prevent the degradation and dephosphorylation of the protein.


These are the 3 main categories of TargetMol kits that CymitQuimica offers:


Protease Inhibitor Cocktail


TargetMol provides a wide array of customizable Protease Inhibitor Cocktails with varying mechanisms of action, aimed at protecting your protein samples. They work by helping proteins avoid rapid degradation caused by endogenous proteases during the cell lysis and protein purification processes. The Protease Inhibitor Cocktail I contains six protease inhibitors with broad specificity, aimed at facilitating the inhibition of aspartyl, cysteine, serine, as well as several aminopeptidases.


Phosphatase Inhibitor Cocktail


The phosphatase inhibitor mixture can effectively inhibit the dephosphorylation of common phosphatases on proteins and maintain the original phosphorylation state of proteins. TargetMol can offer 3 different cocktails based on their form to adjust to the customer requirements.


Cell Cycle Related Kits


Analysis of nucleic acids is a common application of flow cytometry. Measurement of DNA content allows the study of cell populations in various phases of the cell cycle as well as the analysis of DNA ploidy. Flow cytometric analysis is used to produce a frequency histogram that reveals the various phases of the cell cycle. Univariate DNA content analysis is an established assay method and is widely used for studies in oncology, cell biology, and molecular biology.


In this category, CymitQuimica offers TargetMol kits that can be used in the following applications:



The catalogue of products is wide and can be also customized based on the requirements from the researcher. We invite all researchers to explore them and contact our technical support team at support@cymitquimica.com


There are some examples of kits that have been used in relevant research from top institutions:



  • Protease Inhibitor Cocktail: Cao, L. et al (2019, September 11). The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host Microbe, 26(3).



https://doi.org/10.1016/j.chom.2019.08.010



  • Phosphatase Inhibitor Cocktail II (100× DMSO) Sun, Y. et al (2020, February 25). Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells. Frontiers in Pharmacology.



https://doi.org/10.3389/fphar.2020.00116



  • Protease Inhibitor Cocktail: Li, JH., Zhu, XX., Li, FX. et al. MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway. J Exp Clin Cancer Res 38, 476 (2019).



https://doi.org/10.1186/s13046-019-1477-4

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