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Endotoxin Inhibitor
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Endotoxin Inhibitor

CAS: 147396-10-9

Ref. 01-4014453

1mg
72.00 €Add to cart
5mg
241.00 €Add to cart
Estimated delivery in United States, on Monday 29 Aug 2022

Product Information

Name:
Endotoxin Inhibitor
Synonyms:
  • K-T-K-C-K-F-L-K-K-C
  • H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH (Disulfide bond)
  • H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-Oh
Description:

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 107 M-1. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.

Long term storage:
Notes:

Chemical properties

Molecular weight:
1224.6
Formula:
C55H97N15O12S2
Purity:
98.8%
Color/Form:
White Powder
MDL:
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EINECS:
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Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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