- Z-Leu-Arg-Gly-Gly-7-Amino-4-Methylcoumarin Amc
Z-LRGG-AMC is a fluorogenic substrate for isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases (UCHs) based on the C-termini of ubiquitin with a kcat/Km value of 18 M-1s-1. Together with our product I-1690 it forms the basis of continuous assays for precise mechanistic studies or microtiter plate assays for high-throughput inhibitor screening. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and 7. Stock solutions of Boc-LRGG-AMC are best prepared in DMSO.
Technical inquiry about: 01-4027157 Z-Leu-Arg-Gly-Gly-AMC
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