Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g)
- Ph-CN₂-Ph-polymer, PDDM resin
Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of b-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane. Fmoc-a-amino alcohols can be anchored to PDDM in the presence of BF3 etherate. As the resulting benzhydryl ethers can be cleaved with 1% TFA/DCM, fully protected peptide alcohols can be obtained.
Technical inquiry about: 01-4027172 Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g)
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