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L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester
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L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

CAS: 88321-09-9

Ref. 01-4027911

1mg
135.00 €Add to cart
5mg
506.00 €Add to cart
Estimated delivery in United States, on Monday 29 Aug 2022

Product Information

Name:
L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester
Synonyms:
  • L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide
  • 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
  • Aloxistatin
  • E 64c ethyl ester
  • E-64d
  • E64d
  • E64d/pepstatin
  • EST
  • EST (pharmaceutical)
  • Ep 453
  • See more synonyms
  • Loxistatin
  • NSC 694281
  • Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
  • Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-
  • Pepstatin E64d
  • ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate
  • ethyl (2S,3S)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate
Description:

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing b-secretase activity, E64d could reduce brain Ab and improve memory deficits in Alzheimer's disease animal models.

Long term storage:
Notes:

Chemical properties

Molecular weight:
342.44
Formula:
C17H30N2O5
Purity:
> 99%
Color/Form:
White
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
GHS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Technical inquiry about: 01-4027911 L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

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