Orexin A (human, mouse, rat)
- Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse
- OrexinA (human)
- Bovine orexin A
- Human orexin A
- Mouse orexin A
- Orexin A (swine)
- Pig orexin A
- Rat orexin A
Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX1R (IC50 = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. The peptide also corresponds to bovine, canine, ovine, and porcine orexin A.
Technical inquiry about: 01-4028262 Orexin A (human, mouse, rat)
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