DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS
CAS: 127134-13-8
Ref. 01-4030716
| 1mg | 321.00 € | ||
| 5mg | 1,231.00 € |
Product Information
- 4-(4-Dimethylaminophenylazo)Benzoyl-Gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-5-[(2-Aminoethyl)Amino]-Naphthalene-1-Sulfonic Acid
- Hiv Protease Fret Substrate I
- Dabcyl-Gaba-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Edans
The fluorogenic HIV-1 protease substrate DABCYL-Gaba-SQNYPIVQ-EDANS consists of an octapeptide with a fluorescent donor (EDANS) and a quenching acceptor (DABCYL), attached at the COOH- and NH2-termini. The g-Abu spacer was inserted to avoid potential steric hindrance of substrate binding by the bulky acceptor. This FRET substrate is cleaved by the HIV-1 protease at the Tyr-Pro bond which results in a time-dependent increase in fluorescence intensity; excitation at 340 nm, emission at 490 nm.
Chemical properties
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