PACAP-27 (human, mouse, ovine, porcine, rat)
CAS: 127317-03-7
Ref. 01-4031084
| 1mg | 583.00 € | ||
| 0.5mg | 350.00 € |
Product Information
- Pituitary Adenylate Cyclase Activating Polypeptide-27 (human, mouse, ovine, porcine, rat), PACAP-38 (1-27) amide (human, mouse, ovine, porcine, rat)
- Pituitary Adenylate Cyclase Activating Polypeptide (1-27) amide (human, ovine, rat)
- H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
- PACAP 27 Amide, Ovine
PACAP-38 and its N-terminal fragment PACAP-27 are neuropeptides originally isolated from ovine hypothalamus, but also found in humans and rats. Both PACAP-27, which shows considerable homology with vasoactive intestinal polypeptide (VIP), and PACAP-38 stimulate adenylate cyclase much more potently than VIP. Specific PACAP receptors have been identified in different tissues and cell lines.Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of a-secretase, thus promoting the non-amyloidogenic processing of amyloid precursor protein.
Chemical properties
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