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Dansyl-Gly-Cys-Val-Leu-Ser-OH
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Dansyl-Gly-Cys-Val-Leu-Ser-OH

CAS: 143744-88-1

Ref. 01-4037632

1mg
203.00 €Add to cart
5mg
756.00 €Add to cart
Estimated delivery in United States, on Monday 22 Aug 2022

Product Information

Name:
Dansyl-Gly-Cys-Val-Leu-Ser-OH
Synonyms:
  • Dansyl-GCVLS
  • Dansyl-Gly-Cys-Val-Leu-Ser-Oh
  • Dns-Gcvls
Description:

Fluorogenic substrate for farnesyl diphosphate farnesyltransferase (FTase). The pentapeptide is based on the C-terminal region of H-Ras with a dansyl group attached to the N-terminus. Due to farnesylation of the cysteine thiol group the dansyl group is placed from a polar to a non-polar molecular environment which is accompanied by an enhancement of fluorescence and a shift to a lower wavelength emission maximum of the dansyl group. Complete conversion of the product results in a decrease of the emission maximum wavelength from 565 nm to 515 nm together with a 13-fold enhancement in fluorescence intensity at 505 nm. Dansyl-GCVLS can be used for continuously monitoring FTase activity in the presence of farnesyl diphosphate (FPP) at 505 nm using an excitation wavelength of 340 nm (kcat = 0.5 s-1; Km = 1.4 uM). It represents a useful tool for screening potential FTase inhibitors. The substrate is highly specific to FTase and is not recognized by geranylgeranyl transferse type I (GGTase I). Concentrations of stock solutions of Dns-GCVLS can be calculated from the extinction coefficient of the dansyl moiety (e340 = 4250 M-1cm-1 in 20 mM Tris-HCl, pH 7.5, 10 mM EDTA).

Long term storage:
Notes:

Chemical properties

Molecular weight:
710.87
Formula:
C31H46N6O9S2
Purity:
92.2%
Color/Form:
Yellowish Lyophilisate
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
GHS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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