Product Information
- Z-Ile-Leu-Aldehyde
- Z-Il-Cho
Z-IL-CHO, a cell-permeable, reversible inhibitor, reduces amyloid b (Ab)-production by blocking g-secretase activity in vitro (Ab40 IC50 = 7.9 uM; Ab42 IC50 = 7.6 uM). Besides blocking the formation of Ab the dipeptide aldehyde Z-IL-CHO also blocks the production of the g-CTF (g-secretase-generated carboxyl-terminal fragment), but does not affect the formation of amyloid-b-precursor protein (APP).
Chemical properties
Technical inquiry about: 01-4048245 Z-Ile-Leu-aldehyde
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