As described by Peled and coworkers, BKT140 (4F-benzoyl-TN14003) is a biostable, high-affinity chemokine receptor CXCR4 antagonist, which binds CXCR4 with a greater affinity than plerixafor. When combined with G-CSF (granulocyte colony-stimulating factor), BKT140 is a safe and efficient stem cell mobilizer that enabled the collection of a high number of CD34+ cells in 1 and 2 aphaeresis procedures, resulting in successful engraftment.
Technical inquiry about: 01-4073017 BKT140
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