Product Information
Antagonist of formyl peptide receptor-like 1 (FPRL1) signalling. WRW4 inhibits WKYMVm binding to FPRL1 (IC50 0.23 mM) as well as the intracellular calcium release induced by WKYMVm, MMK-1, amyloid b42, and F peptide. The tryptophan-rich peptide also inhibits FPRL1-mediated signalling in human neutrophils and blocks chemotactic migration and superoxide generation by Ab42. WRW4 inhibited the activation of FPRL2 by F2L, an FPRL2-selective endogenous agonist, resulting in the complete inhibition of intracellular calcium increase and chemotactic migration.
Chemical properties
Technical inquiry about: 01-4095537 WRW4
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